Endocrine disruptors and human health: Is there a problem

Toxicology

Volumn 205, Issue 1-2 SPEC. ISS., 2004, Pages 3-10

  Safe, Stephen ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Endocrine disruptors; Human health; Sperm

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ENDOCRINE DISRUPTION CHEMICAL; ENVIRONMENTAL MUTAGEN; ESTROGEN; MUTAGENIC AGENT; ORGANOCHLORINE DERIVATIVE; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG; XENOESTROGEN;

BREAST CANCER; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; CONFERENCE PAPER; DISEASE PREDISPOSITION; ENDOCRINE DISEASE; ENDOCRINE SYSTEM; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; HEALTH HAZARD; HEALTH STATUS; HUMAN; LIFESTYLE; MALE GENITAL SYSTEM DISEASE; PRIORITY JOURNAL; RISK FACTOR; SPERMATOZOON COUNT; TESTIS CANCER;

BREAST NEOPLASMS; ENDOCRINE GLANDS; ESTROGENS; FEMALE; HUMANS; MALE; SPERM COUNT; TESTIS; XENOBIOTICS;

EID: 5344230666     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.06.032     Document Type: Conference Paper

References (77)

1. D.A. Adamopoulos, A. Pappa, S. Nicopoulou, E. Andreou, M. Karamertzanis, J. Michopoulos, V. Deligianni, and M. Simou Seminal volume and total sperm number trends in men attending subfertility clinics in the greater Athens area during the period 1977-1993 Hum. Reprod. 11 1996 1936 1941
2. U.G. Ahlborg, L. Lipworth, L. Titusernstoff, C.C. Hsieh, A. Hanberg, J. Baron, D. Trichopoulos, and H.O. Adami Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence Crit. Rev. Toxicol. 25 1995 463 531
3. O. Akre, S. Cnattingius, R. Bergstrom, U. Kvist, D. Trichopoulos, and A. Ekbom Human fertility does not decline: evidence from Sweden Fertil. Steril. 71 1999 1066 1069
4. P. Andolz, M.A. Bielsa, and J. Vila Evolution of semen quality in North-eastern Spain: a study in 22,759 infertile men over a 36 year period Hum. Reprod 14 1999 731 735
5. K.J. Aronson, A.B. Miller, C.G. Woolcott, E.E. Sterns, D.R. McCready, L.A. Lickley, E.B. Fish, G.Y. Hiraki, C. Holloway, T. Ross, W.M. Hanna, S.K. SenGupta, and J.P. Weber Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk Cancer Epidemiol. Biomarkers Prevent 9 2000 55 63
6. J. Auger, and P. Jouannet Evidence for regional differences of semen quality among fertile French men Hum. Reprod. 12 1997 740 745
7. J. Auger, J.M. Kuntsmann, F. Czyglik, and P. Jouannet Decline in semen quality among fertile men in Paris during the past 20 years N. Engl. J. Med. 332 1995 281 285
8. D. Bagga, K.H. Anders, H.J. Wang, E. Roberts, and J.A. Glaspy Organochlorine pesticide content of breast adipose tissue from women with breast cancer and control subjects J. Natl. Cancer Inst. 92 2000 750 753
9. R. Bergstrom, H.O. Adami, M. Mohner, W. Zatonski, H. Storm, A. Ekbom, S. Tretli, L. Teppo, O. Akre, and T. Hakulinen Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon J. Natl. Cancer Inst. 88 1996 727 733
10. M. Bibbo, W.B. Gill, F. Azizi, R. Blough, V.S. Fang, R.L. Rosenfield, G.F. Schumacher, K. Sleeper, M.G. Sonek, and G.L. Wied Follow-up study of male and female offspring of DES-exposed mothers Obstet. Gynecol. 49 1977 1 18
11. L. Bujan, A. Mansat, F. Pontonnier, and R. Mieusset Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992 Br. Med. J. 312 1992 471 472
12. E. Carlsen, A. Giwercman, N. Keiding, and N.E. Skakkebaek Evidence for the decreasing quality of semen during the past 50 years Br. Med. J. 305 1992 609 612
13. Z. Chen, T. Toth, L. Godfrey-Bailey, N. Mercedat, I. Schiff, and R. Hauser Seasonal variation and age-related changes in human semen parameters J. Androl. 24 2003 226 231
14. T. Colborn, F.S. Vom Saal, and A.M. Soto Developmental effects of endocrine-disrupting chemicals in wildlife and humans Environ. Health Perspect. 101 1993 378 384
15. D.L. Davis, and H.L. Bradlow Can environmental estrogens cause breast cancer Sci. Am. 273 1995 166 171
16. D.L. Davis, H.L. Bradlow, M. Wolff, T. Woodruff, D.G. Hoel, and H. Anton-Culver Medical hypothesis: xenoestrogens as preventable causes of breast cancer Environ. Health Perspect. 101 1993 372 377
17. J.F. Dorgan, J.W. Brock, N. Rothman, L.L. Needham, R. Miller, H.E. Stephenson Jr., N. Schussler, and P.R. Taylor Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis Cancer Causes Control 10 1999 1 11
18. A. Ekbom, A. Wicklund-Glynn, and H.O. Adami DDT and testicular cancer Nature 347 1996 553 554
19. F. Falck, A. Ricci, M.S. Wolff, J. Godbold, and P. Deckers Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer Arch. Environ. Health 47 1992 143 146
20. H. Fisch, E.T. Goluboff, J.H. Olson, J. Feldshuh, S.J. Broder, and D.H. Barad Semen analyses in 1283 men from the United States over a 25-year period: no decline in quality Fertil. Steril. 65 1996 1009 1014
21. M.D. Gammon, M.S. Wolff, A.I. Neugut, S.M. Eng, S.L. Teitelbaum, J.A. Britton, M.B. Terry, B. Levin, S.D. Stellman, G.C. Kabat, M. Hatch, R. Senie, G. Berkowitz, H.L. Bradlow, G. Garbowski, C. Maffeo, P. Montalvan, M. Kemeny, M. Citron, F. Schnabel, A. Schuss, S. Hajdu, V. Vinceguerra, N. Niguidula, K. Ireland, and R.M. Santella Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood Cancer Epidemiol. Biomarkers Prevent 11 2002 686 697
22. W.B. Gill, G.F. Schumacher, M. Bibbo, F.H. Straus, and H.W. Schoenberg Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities J. Urol. 122 1979 36 39
23. R.M. Giusti, K. Iwamoto, and E.E. Hatch Diethylstilbestrol revisited: a review of the long-term health effects Ann. Intern. Med. 122 1995 778 788
24. S. Guttes, K. Failing, K. Neumann, J. Kleinstein, S. Georgii, and H. Brunn Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease Arch. Environ. Contam. Toxicol. 35 1998 140 147
25. J. Gyllenborg, N.E. Skakkebaek, N.C. Nielsen, N. Keiding, and A. Giwercman Secular and seasonal changes in semen quality among young Danish men: a statistical analysis of semen samples from 1927 donor candidates during 1977-1995 Int. J. Androl. 22 1999 28 36
26. D.J. Handelsman Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers Hum. Reprod. 12 1997 2701 2705
27. K.J. Helzlsouer, A.J. Alberg, H.Y. Huang, S.C. Hoffman, P.T. Strickland, J.W. Brock, V.W. Burse, L.L. Needham, D.A. Bell, J.A. Lavigne, J.D. Yager, and G.W. Comstock Serum concentrations of organochlorine compounds and the subsequent development of breast cancer Cancer Epidemiol. Biomarkers Prevent 8 1999 525 532
28. E. Hemminki, M. Gissler, and J. Merilainen Reproductive effects of in utero exposure to estrogen and progestin drugs Fertil. Steril. 71 1999 1092 1098
29. B.E. Henderson, B. Benton, M. Cosgrove, J. Baptista, J. Aldrich, D. Townsend, W. Hart, and T.M. Mack Urogenital tract abnormalities in sons of women treated with diethylstilbestrol Pediatrics 58 1976 505 507
30. T.R. Holford, T. Zheng, S.T. Mayne, S.H. Zahm, J.D. Tessari, and P. Boyle Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk Int. J. Epidemiol. 29 2000 975 982
31. A.P. Hoyer, P. Grandjean, T. Jorgensen, J.W. Brock, and H.B. Hartvig Organochlorine exposure and risk of breast cancer Lancet 352 1998 1816 1820
32. A.P. Hoyer, T. Jorgensen, J.W. Brock, and P. Grandjean Organochlorine exposure and breast cancer survival J. Clin. Epidemiol. 53 2000 323 330
33. D.J. Hunter, S.E. Hankinson, F. Laden, G. Colditz, J.E. Munson, W.C. Willett, F.E. Speizer, and M.S. Wolff Plasma organochlorine levels and the risk of breast cancer N. Engl. J. Med. 337 1997 1253 1258
34. S. Irvine, E. Cawood, D. Richardson, E. MacDonald, and J. Aitken Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years Br. Med. J. 312 1996 467 471
35. N. Itoh, F. Kayama, T.J. Tatsuki, and T. Tsukamoto Have sperm counts deteriorated over the past 20 years in healthy, young Japanese men? Results from the Sapporo area J. Androl. 22 2001 40 44
36. M. Joffe Time trends in biological fertility in Britain Lancet 355 2000 1961 1965
37. N. Jorgensen, A.G. Andersen, F. Eustache, D.S. Irvine, J. Suominen, J.H. Petersen, A.N. Andersen, J. Auger, E.H. Cawood, A. Horte, T.K. Jensen, P. Jouannet, N. Keiding, M. Vierula, J. Toppari, and N.E. Skakkebaek Regional differences in semen quality in Europe Hum. Reprod. 16 2001 1012 1019
38. N. Jorgensen, E. Carlsen, N. Ingrid, M. Punab, J. Suominen, A.G. Andersen, A.M. Andersson, T.B. Haugen, A. Horte, T.K. Jensen, O. Magnus, J.H. Petersen, M. Vierula, J. Toppari, and N.E. Skakkebaek East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland Hum. Reprod. 17 2002 219 228
39. N. Krieger, M.S. Wolff, R.A. Hiatt, M. Rivera, J. Vogelman, and N. Orentreich Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women J. Natl. Cancer Inst. 86 1994 589 599
40. F.W. Kutz, P.H. Wood, and D.P. Bottimore Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue Rev. Environ. Contamin. Toxicol. 120 1991 1 82
41. L. López-Carrillo, A. Blair, M. López-Cervantes, M. Cebrián, C. Rueda, R. Reyes, A. Mohar, and J. Bravo Dichlorodiphenyltrichloroethane serum levels and breast cancer risk: a case-control study from Mexico Cancer Res. 57 1997 3728 3732
42. F. Laden, G. Collman, K. Iwamoto, A.J. Alberg, G.S. Berkowitz, J.L. Freudenheim, S.E. Hankinson, K.J. Helzlsouer, T.R. Holford, H.Y. Huang, K.B. Moysich, J.D. Tessari, M.S. Wolff, T. Zheng, and D.J. Hunter 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five US studies J. Natl. Cancer Inst. 93 2001 768 776
43. F. Laden, S.E. Hankinson, M.S. Wolff, G.A. Colditz, W.C. Willett, F.E. Speizer, and D.J. Hunter Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses' Health Study Int. J. Cancer 91 2001 568 574
44. G. Liljegren, L. Hardell, G. Lindstrom, P. Dahl, and A. Magnuson Case-control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene Eur. J. Cancer Prevent 7 1998 135 140
45. M. Lopez-Cervantes, L. Torres-Sanchez, A. Tobias, and L. Lopez-Carrillo Dichlorodiphenyldichloroethane burden and breast cancer risk: a meta-analysis of the epidemiologic evidence Environ. Health Perspect. 112 2004 207 214
46. G.A.S. Mendonca, J. Eluf-Neto, M.J. Andrada-Serpa, P.A.O. Carmo, H.H.C. Barreto, O.N.K. Inomata, and T.A. Kussumi Organochlorines and breast cancer: a case-control study in Brazil Int. J. Cancer. 83 1999 596 600
47. R. Millikan, E. DeVoto, E.J. Duell, C.K. Tse, D.A. Savitz, J. Beach, S. Edmiston, S. Jackson, and B. Newman Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African-American and white women in North Carolina Cancer Epidemiol. Biomarkers Prevent 9 2000 1233 1240
48. K.B. Moysich, C.B. Ambrosone, J.E. Vena, P.G. Shields, P. Mendola, P. Kostyniak, H. Greizerstein, S. Graham, J.R. Marshall, E.F. Schisterman, and J.L. Freudenheim Environmental organochlorine exposure and postmenopausal breast cancer risk Cancer Epidemiol. Biomarkers Prevent 7 1998 181 188
49. R. Newbold Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens Environ. Health Perspect. 103 1995 83 87
50. K. Noren, and D. Meironyte Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years Chemosphere 40 2000 1111 1123
51. L.J. Paulozzi International trends in rates of hypospadias and cryptorchidism Environ. Health Perspect. 107 1999 297 302
52. C.A. Paulsen, N.G. Berman, and C. Wang Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform Fertil. Steril. 65 1996 1015 1020
53. P.E. Rasmussen, K. Erb, and L.G. Westergaard No evidence for decreasing semen quality in four birth cohorts of 1055 Danish men born between 1950 and 1970 Fertil. Steril. 68 1979 1059 1069
54. I. Romieu, M. Hernandez-Avila, E. Lazcano-Ponce, J.P. Weber, and E. Dewailly Breast cancer, lactation history, and serum organochlorines Am. J. Epidemiol. 152 2000 363 370
55. S. Safe Dietary and environmental estrogens and antiestrogens and their possible role in human disease Environ. Sci. Pollut. Res. 1 1994 29 33
56. S. Safe Environmental and dietary estrogens and human health - is there a problem? Environ. Health Perspect. 103 1995 346 351
57. A. Schecter, P. Toniolo, L.C. Dai, L.T. Thuy, and M.S. Wolff Blood levels of DDT and breast cancer risk among women living in the north of Vietnam Arch. Environ. Contam. Toxicol. 33 1997 453 456
58. R.M. Sharpe, and N.E. Skakkebaek Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract Lancet 341 1993 1392 1395
59. N.E. Skakkebaek, M.E. Rajpert-De, and K.M. Main Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects Hum. Reprod. 16 2001 972 978
60. S.D. Stellman, M.V. Djordjevic, J.A. Britton, J.E. Muscat, M.L. Citron, M. Kemeny, E. Busch, and L. Gong Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York Cancer Epidemiol. Biomarkers Prevent 9 2000 1241 1249
61. R.J. Stillman In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance in male and female offspring Am. J. Obstet. Gynecol. 142 1982 905 921
62. L. Storgaard, J.P. Bonde, E. Ernst, C.Y. Andersen, K.O. Kyvik, and J. Olsen Effect of prenatal exposure to oestrogen on quality of semen: comparison of twins and singleton brothers Br. Med. J. 325 2002 252 253
63. S.H. Swan, C. Brazil, E.Z. Drobnis, F. Liu, R.L. Kruse, M. Hatch, J.B. Redmon, C. Wang, J.W. Overstreet and Study For Future Families Research Group Geographic differences in semen quality of fertile US males Environ. Health Perspect. 111 2003 414 420
64. A.J. Swerdlow, B.L. De Stavola, M.A. Swanwick, and N.E. Maconochie Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology Lancet 350 1997 1723 1728
65. I. Tortolero, A.G. Bellabarba, R. Lozano, C. Bellabarba, I. Cruz, and J.A. Osuna Semen analysis in men from Merida, Venezuela, over a 15-year period Arch. Androl. 42 1999 29 34
66. I.S. Tummon, and D. Mortimer Decreasing quality of semen Br. Med. J. 305 1992 1228 1229
67. P. Van't Veer, I.E. Lobbezoo, J.M. Martin-Moreno, E. Guallar, J. Gomez-Aracena, A.F.M. Kardinaal, L. Kohlmeier, B.C. Martin, J.J. Strain, M. Thamm, P. Van Zoonen, B.A. Baumann, J.K. Huttunen, and F.J. Kok DDT (dicophane) and postmenopausal breast cancer in Europe: case control study Br. J. Med. 315 1997 81 85
68. K. Van Waeleghem, N. De Clercq, L. Vermeulen, F. Schoonjans, and F. Comhaire Deterioration of sperm quality in young healthy Belgian men Hum. Reprod. 11 1996 325 329
69. E.M. Ward, P. Schulte, B. Grajewski, A. Andersen, D.G.J. Patterson, W. Turner, E. Jellum, J.A. Deddens, J. Friedland, N. Roeleveld, M. Waters, M.A. Butler, E. DiPietro, and L.L. Needham Serum organochlorine levels and breast cancer: a nested case-control study of Norwegian women Cancer Epidemiol. Biomarkers Prevent 9 2000 1357 1367
70. A.J. Wilcox, D.D. Baird, C.R. Weinberg, P.P. Hornsby, and A.L. Herbst Fertility in men exposed prenatally to diethylstilbestrol N. Engl. J. Med. 332 1995 1411 1416
71. M.S. Wolff, G.S. Berkowitz, S. Brower, R. Senie, I.J. Bleiweiss, P. Tartter, B. Pace, N. Roy, S. Wallenstein, and A. Weston Organochlorine exposures and breast cancer risk in New YorkCity women Environ. Res. 84 2000 151 161
72. M.S. Wolff, P.G. Toniolo, E.W. Leel, M. Rivera, and N. Dubin Blood levels of organochlorine residues and risk of breast cancer J. Natl. Cancer Inst. 85 1993 648 652
73. E.V. Younglai, J.A. Collins, and W.G. Foster Canadian semen quality: an analysis of sperm density among eleven academic fertility centers Fertil. Steril. 70 1998 76 80
74. T. Zheng, T.R. Holford, S.T. Mayne, J. Tessari, B. Ward, D. Carter, P.H. Owens, P. Boyle, R. Dubrow, S. Archibeque-Engle, O. Dawood, and S.H. Zahm Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2′-bis(p-chlorophenyl)ethylene Cancer Epidemiol. Biomarkers Prevent 9 2000 167 174
75. T. Zheng, T.R. Holford, J. Tessari, S.T. Mayne, P.H. Owens, B. Ward, D. Carter, P. Boyle, R. Dubrow, S. Archibeque-Engle, and S.H. Zahm Breast cancer risk associated with congeners of polychlorinated biphenyls Am. J. Epidemiol. 152 2000 50 58
76. Y. Zheng, J.P.E. Bonde, E. Ernst, J.T. Mortensen, and J. Egense Is semen quality related to the year of birth among Danish infertility clients Int. J. Epidemiol. 26 1997 1289 1297
77. B. Zorn, I. Virant-Klun, I. Verdenik, and H. Meden-Vrtovec Semen quality changes among 2343 healthy Slovenian men included in an IVF-ET programme from 1983 to 1996 Int. J. Androl. 22 1996 178 183