Different guidelines for imaging after first UTI in febrile infants: Yield, cost, and radiation

Pediatrics

Volumn 131, Issue 3, 2013, Pages

  Scola, Claudio La ^a   De Mutiis, Chiara ^a   Hewitt, Ian K ^b   Puccio, Giuseppe ^c   Toffolo, Antonella ^d   Zucchetta, Pietro ^e   Mencarelli, Francesca ^a   Marsciani, Martino ^a   Roberto Dall'Amico, ^f   Montini, Giovanni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^c UNIVERSITY OF PALERMO   (Italy)

^d Hospital of Oderzo   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f Pordenone Hospital   (Italy)

Author keywords

Guidelines; Renal DMSA scan; Urinary tract infection; Vesicoureteral reflux; Voiding cystourethrography

Indexed keywords

SUCCIMER TC 99M;

ALGORITHM; ARTICLE; CHILD; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CYSTOGRAPHY; CYSTOURETHROGRAPHY; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST ACCURACY STUDY; ECHOGRAPHY; FEMALE; FEVER; FOLLOW UP; HEALTH CARE COST; HEALTH ECONOMICS; HUMAN; INFANT; KIDNEY SCINTISCANNING; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; MULTICENTER STUDY (TOPIC); OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION EXPOSURE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; URINARY TRACT INFECTION; VESICOURETERAL REFLUX;

CHILD, PRESCHOOL; COST-BENEFIT ANALYSIS; FEMALE; FEVER; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; PRACTICE GUIDELINES AS TOPIC; PROSPECTIVE STUDIES; RADIATION DOSAGE; URINARY TRACT INFECTIONS;

EID: 84874602070     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-0164     Document Type: Article

References (35)

1. Salo J, Ikäheimo R, Tapiainen T, Uhari M. Childhood urinary tract infections as a cause of chronic kidney disease. Pediatrics. 2011;128(5):840-847
2. Round J, Fitzgerald AC, Hulme C, Lakhanpaul M, Tullus K. Urinary tract infections in children and the risk of ESRF. Acta Paediatr. 2011;101(3):278-282
3. Westwood ME, Whiting PF, Cooper J, Watt IS, Kleijnen J. Further investigation of confirmed urinary tract infection (UTI) in children under five years: a systematic review. BMC Pediatr. 2005;5(1):2
4. Ardissino G, Daccò V, Testa S, et al; Ital Kid Project. Epidemiology of chronic renal failure in children: data from the Ital Kid project. Pediatrics. 2003;111(4). Available at: www.pediatrics.org/cgi/content/ full/111/4/e382
5. North American Pediatric Renal Trials and Collaborative Studies. Annual report, 2008. Available at: https://web.emmes.com/study/ped. Accessed January 30, 2012
6. Wennerström M, Hansson S, Jodal U, Stokland E. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr. 2000;136(1):30-34
7. Broyer M, Chantler C, Donckerwolcke R, Ehrich JH, Rizzoni G, Schärer K. The paediatric registry of the European Dialysis and Transplant Association: 20 years' experience. Pediatr Nephrol. 1993;7(6):758-768
8. Esbjörner E, Berg U, Hansson S; Swedish Pediatric Nephrology Association. Epidemiology of chronic renal failure in children: a report from Sweden 1986-1994. Pediatr Nephrol. 1997;11(4):438-442
9. Garin EH, Olavarria F, Garcia Nieto V, Valenciano B, Campos A, Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics. 2006;117(3):626-632
10. Roussey-Kesler G, Gadjos V, Idres N, et al. Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study. J Urol. 2008;179(2):674-679
11. Pennesi M, Travan L, Peratoner L, et al; North East Italy Prophylaxis in VUR study group. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics. 2008;121(6): Available at www.pediatrics.org/cgi/ content/full/121/6/e1489
12. Montini G, Rigon L, Zucchetta P, et al; IRIS Group. Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics. 2008;122(5):1064-1071
13. Craig JC, Simpson JM, Williams GJ, et al; Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) Investigators. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2009;361(18):1748-1759
14. Brandström P, Esbjörner E, Herthelius M, Swerkersson S, Jodal U, Hansson S. The Swedish reflux trial in children: III. Urinary tract infection pattern. J Urol. 2010;184(1): 286-291
15. Montini G, Tullus K, Hewitt I. Febrile urinary tract infections in children. N Engl J Med. 2011;365(3):239-250
16. Cincinnati Children's Hospital Medical Center. Evidence-Based Care Guideline for Medical Management of First Urinary Tract Infection in Children 12 Years of Age or Less. Cincinnati, OH: Cincinnati Children's Hospital Medical Center; 2006
17. Royal Children's Hospital Melbourne. Clinical practice guidelines. Available at: www.rch.org.au/clinicalguide/cpg.cfm?doc-id=5241. Accessed January 28, 2012
18. National Institute for Health and Clinical Excellence. Urinary tract infection in children: diagnosis, treatment and long term management. Available at: www.nice.org. uk/nicemedia/pdf/CG54fullguideline.pdf. Accessed January 15, 2012
19. Preda I, Jodal U, Sixt R, Stokland E, Hansson S. Normal dimercaptosuccinic acid scintigraphy makes voiding cystourethrography unnecessary after urinary tract infection. J Pediatr. 2007;151(6):581-584, e1
20. Roberts KB; Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011;128(3):595-610
21. Ammenti A, Cataldi L, Chimenz R, et al; Italian Society of Pediatric Nephrology. Febrile urinary tract infections in young children: recommendations for the diagnosis, treatment and follow-up. Acta Paediatr. 2012;101(5):451-457
22. Montini G, Toffolo A, Zucchetta P, et al. Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. BMJ. 2007;335 (7616):386
23. Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987;34(3):571-590
24. Hoberman A, Charron M, Hickey RW, Baskin M, Kearney DH, Wald ER. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003;348 (3):195-202
25. Smith T, Evans K, Lythgoe MF, Anderson PJ, Gordon I. Radiation dosimetry of technetium-99m-DMSA in children. J Nucl Med. 1996;37 (8):1336-1342
26. Stefanidis CJ, Siomou E. Imaging strategies for vesicoureteral reflux diagnosis. Pediatr Nephrol. 2007;22(7):937-947
27. American Urological Association. Clinical guidelines. Available at: www.auanet.org/content/guidelines-and-quality-care/clinicalguidelines. cfm?sub=vur2010. Accessed January 15, 2012
28. Finnell SM, Carroll AE, Downs SM; Subcommittee on Urinary Tract Infection. Technical report-Diagnosis and management of an initial UTI in febrile infants and young children. Pediatrics. 2011;128(3). Available at: www.pediatrics.org/cgi/content/full/128/3/e749
29. Lebowitz RL, Olbing H, Parkkulainen KV, Smellie JM, Tamminen-Möbius TE; International Reflux Study in Children. International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol. 1985;15(2):105-109
30. Leroy S, Romanello C, Smolkin V, et al. Prediction of moderate and high grade vesicoureteral reflux after a first febrile urinary tract infection in children: construction and internal validation of a clinical decision rule. J Urol. 2011;187(1):265-271
31. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics. 2010;126(6):1084-1091
32. Montini G, Zucchetta P, Tomasi L, et al. Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian Renal Infection Study 1. Pediatrics. 2009;123(2). Available at: www.pediatrics. org/cgi/content/full/123/2/e239
33. Sinha MD, Gibson P, Kane T, Lewis MA. Accuracy of ultrasonic detection of renal scarring in different centres using DMSA as the gold standard. Nephrol Dial Transplant. 2007;22(8):2213-2216
34. Perisinakis K, Raissaki M, Damilakis J, Stratakis J, Neratzoulakis J, Gourtsoyiannis N. Fluoroscopy-controlled voiding cystourethrography in infants and children: are the radiation risks trivial? Eur Radiol. 2006;16(4):846-851
35. Rajaraman P, Simpson J, Neta G, et al. Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study. BMJ. 2011;342: d472