Shorter Telomere Length - A Potential Susceptibility Factor for HIV-Associated Neurocognitive Impairments in South African Woman

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Malan Müller, Stefanie ^a   Hemmings, Sîan Megan Joanna ^a   Spies, Georgina ^a   Kidd, Martin ^b   Fennema Notestine, Christine ^c   Seedat, Soraya ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; BLOOD SAMPLING; CHILDHOOD INJURY; CHROMOSOME SIZE; CHRONIC STRESS; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ACTIVITY; DNA EXTRACTION; ETHNIC GROUP; FEMALE; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC SUSCEPTIBILITY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEARNING; LEUKOCYTE STRUCTURE; MAJOR CLINICAL STUDY; MENTAL PERFORMANCE; NEUROLOGIC EXAMINATION; RISK FACTOR; SOUTH AFRICAN; VERBALIZATION; ADOLESCENT; ANALYSIS OF VARIANCE; BLOOD; CHILD ABUSE; GENETICS; MENTAL STRESS; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NEUROPSYCHOLOGICAL TEST; POSTTRAUMATIC STRESS DISORDER; SOUTH AFRICA; TELOMERE; ULTRASTRUCTURE; YOUNG ADULT;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; CHILD ABUSE; FEMALE; HIV INFECTIONS; HUMANS; LEARNING; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SOUTH AFRICA; STRESS DISORDERS, TRAUMATIC; STRESS, PSYCHOLOGICAL; TELOMERE; YOUNG ADULT;

EID: 84874600708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058351     Document Type: Article

References (49)

1. Statistics South Africa website, Statistical release P0302. Available: http://www.statssa.gov.za/publications/P0302/P03022011.pdf. Accessed April 2012.
2. HIV and AIDS statistics for South Africa website. Available: http://www.avert.org/safricastats.htm. Accessed April 2012.
3. Dunkle KL, Jewkes RK, Brown HC, Gray GE, McIntyre JA, et al. (2004) Gender-based violence, relationship power and risk of prevalent HIV infection among women attending antenatal clinics in Soweto, South Africa. Lancet 363: 1415-1421.
4. Shonkoff JP, Boyce WT, McEwen BS, (2009) Neuroscience, molecular biology, and the childhood roots of health disparities. Building a new framework for health promotion and disease prevention. JAMA 301: 2252-2259.
5. Hult B, Chana G, Masliah E, Everall I, (2008) Neurobiology of HIV. Int Rev Psychiatry 20: 3-13.
6. Woods SP, Moore D, Weber E, (2009) Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19: 152-168.
7. Grant I, (2008) Neurocognitive disturbances in HIV. Int Rev Psychiatr 20: 33-47.
8. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, et al. (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69: 1789-1799.
9. Heaton RK, Grant I, Butters N, Heaton RK, Grant I, et al. (1995) The HNRC 500-neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center. JINS 1: 231-251.
10. Joska JA, Fincham DS, Stein DJ, Paul RH, Seedat S, (2010) Clinical correlates of HIV-associated neurocognitive disorders in South Africa. AIDS Behav 14: 371-378.
11. Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, et al. (2011) HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 17: 3-16.
12. Oeseburg H, de Boer UA, van Gilst WH Van der Harst P, (2010) Telomere biology in healthy aging and disease. Eur J Physiol 459: 259-268.
13. Houben JMJ, Moonen HJJ, Van Schooten FJ Hageman GJ, (2008) Telomere length assessment: Biomarker of chronic oxidative stress? Free Radic Biol Med 44: 235-246.
14. Callen E, Surralles J, (2004) Telomere dysfunction in genome instability syndromes. Mutat Res 567: 85-104.
15. Thurnher D, Bakroeva M, Formanek M Knerer B, Kornfehl J, (2001) Non-steroidal anti-inflammatory drugs inhibit telomerase activity in head and neck squamous carcinoma cell lines. Head & Neck 23: 1049-1055.
16. Epel ES, Merkin SS, Cawthon R Blackburn EH, Adler NE, Pletcher MJ, et al. (2008) The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging 1: 81-88.
17. Nordfjäll K, Eliasson M, Stegmayr B Melander O, Nilsson P, et al. (2008) Telomere length is associated to obesity parameters but with a gender difference. Obesity 16: 2682-2689.
18. Puterman E, Lin J, Blackburn E, O'Donovan A, Adler N, et al. (2010) The Power of Exercise: Buffering the Effect of Chronic Stress on Telomere Length. PLoS ONE 5: e10837.
19. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, et al. (2005) Obesity, cigarette smoking, and telomere length in women. Lancet 366: 662-64.
20. Von Zglinicki T, Martin-Ruiz CM, (2005) Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med 5: 197-203.
21. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA, (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361: 393-395.
22. Obana N, Takagi S, Kinouchi Y, Tokita Y, Sekikawa A, et al. (2003) Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders. Intern Med 42: 150-153.
23. Zglinicki T, Martin-Ruiz CM, (2005) Telomeres as Biomarkers for Ageing and Age-Related Diseases. Curr Mol Med 5(2): 197-203.
24. Liu J, Mori A, (1999) Stress, aging, and brain oxidative damage. Neurochem Res 24: 1479-1497.
25. Irie M, Asami S, Nagata S, Miyata M, Kasai H, (2002) Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers. Psychother Psychosom 71: 90-96.
26. Irie M, Asami S, Ikeda M, Kasai H, (2003) Depressive state relates to female oxidative DNA damage via neutrophil activation. Biochem Biophys Res Commun 311: 1014-1018.
27. Tsuboi H, Shimoi K, Kinae N, Oguni I, Hori R, et al. (2004) Depressive symptoms are independently correlated with lipid peroxidation in a female population: comparison with vitamins and carotenoids. J Psychosom Res 56 1: 53-58.
28. Forlenza MJ, Miller GE, (2006) Increased serum levels of 8-hydroxy-2_- deoxyguanosine in clinical depression. Psychosom Med 68: 1-7.
29. Haendeler J, Hoffmann J, Brandes RP, Zeiher AM, Dimmeler S, (2003) Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol 23: 4598-4610.
30. Haendeler J, Hoffmann J, Vasa M, Spyridopoulos I, Zeiher AM, et al. (2004) Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res 94 6: 768-775.
31. Appay V, Rowland-Jones SL, (2002) Premature ageing of the immune system: the cause of AIDS? Trends Immunol 23: 580-585.
32. Effros RB, (2000) Telomeres and HIV disease. Microbes Infect 2: 69-76.
33. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, et al. (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci US 101: 17312-17315.
34. Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, et al. (2010) Childhood Maltreatment and Telomere Shortening: Preliminary Support for an Effect of Early Stress on Cellular Aging. Biol Psychiatry 67: 531-534.
35. Kananen L, Surakka I, Pirkola S, Suvisaari J, Lonnqvist J et al. (2010) Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One 5: p. e10826.
36. O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, et al. (2011) Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry 70: 465-471.
37. Glass D, Parts L, Knowles D, Aviv A, Spector TD, (2010) No correlation between childhood maltreatment and telomere length. Biol Psychiatry 68: e21-e22.
38. Bernstein DP, Ahluvalia T, Pogge D, Handelsman L (1997) Validity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population. J Am Acad Child Adolesc Psychiatry (Suppl 3): 340-348.
39. Cawthon RM, (2002) Telomere measurement by quantitative PCR. Nucl Acids Res 30: e47.
40. GenEx, Software for gene expression analysis. Available at: http://www.gene-quantification.de/datan.html. Accessed February 1, 2011.
41. Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, et al. (2003) Development and validation of a brief screening version of the childhood trauma questionnaire. Child Abuse & Neglect 27: 169-190.
42. Bremner JD, (2002) Neuroimaging of childhood trauma. Semin Clin Neuropsychiatry 7: 104-112.
43. Gleissner U, Elger CE, (2001) The hippocampal contribution to verbal fluency in patients with temporal lobe epilepsy. Cortex 37: 55-63.
44. Nakamura K, Takubo K, Izumiyama-Shimomura N, Sawabe M, Arai T et al. (2007) Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older. Exp Gerontol (Suppl 10): 944-950.
45. Wolthers KC, Bea G, Wisman PE, Otto SA, de Roda Husman AM, et al. (1996) T cell telomere length in HIV-1 infection. No evidence for increased CD4+ turnover. Science 274: 1546-1547.
46. Harris SE, Deary IJ, Maclntyre A, Lamb KJ, Radhakrishnan K, et al. (2006) The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci Lett 406: 260-264.
47. Son NH, Murray S, Yanovski J, Hodes RJ, Weng N, (2000) Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immunol 165: 1191-96.
48. Kurosaka D, Yasuda J, Yoshida K, Yoneda A, Yasuda C, et al. (2006) Abnormal telomerase activity and telomere length in T and B cells from patients with systemic lupus erythematosus. J Rheumatol 33: 1102-1107.
49. Wu KD, Hansen ER, (2001) Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis. Exp Dermatol 10: 329-336.