Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines

Molecules

Volumn 18, Issue 2, 2013, Pages 1985-1994

  Teh, Soek Sin ^a   Ee, Gwendoline Cheng Lian ^a   Mah, Siau Hui ^a   Lim, Yang Mooi ^b   Ahmad, Zuraini ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TUNKU ABDUL RAHMAN   (Malaysia)

Author keywords

Cytotoxicity; Mesua beccariana; Mesua congestiflora; Mesua ferrea; Structure activity relationship; Xanthones

Indexed keywords

QUERCETIN; XANTHONE; XANTHONE DERIVATIVE;

ARTICLE; CELL DEATH; CHEMISTRY; CLUSIACEAE; DRUG EFFECT; DRUG SCREENING; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

CELL DEATH; CELL LINE, TUMOR; CLUSIACEAE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; QUERCETIN; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

MLCS; MLOWN;

EID: 84874594643     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18021985     Document Type: Article

References (22)

1. Verotta, L. Hypericum perforatum, a source of neuroactive lead structures. Curr. Top. Med. Chem. 2003, 3, 187-201.
2. Verotta, L. Are acylphloroglucinols lead structures for the treatment of degenerative diseases? Phytochem. Rev. 2003, 1, 389-407. (Pubitemid 41413234)
3. Verotta, L.; Lovaglio, E.; Vidari, G.; Finzi, P.V.; Neri, M.G.; Raimondi, A.; Parapini, S.; Taramelli, D.; Riva, A.; Bombardelli, E. 4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials. Phytochemistry 2004, 65, 2867-2879. (Pubitemid 40292118)
4. Niu, S.-L.; Li, Z.-L.; Ji, F.; Liu, G.-Y.; Zhao, N.; Liu, X.-Q.; Jing, Y.-K.; Hua, H.-M. Xanthones from the stem bark of Garcinia bracteata with growth inhibitory effects against HL-60 cells. Phytochemistry 2012, 77, 280-286.
5. Yi, B.; Hu, L.; Mei, W.; Zhou, K.; Wang, H.; Luo, Y.; Wei, X.; Dai, H. Antioxidant Phenolic Compounds of Cassava (Manihot esculenta) from Hainan. Molecules 2010, 16, 10157-10167.
6. Jantan, I.; Juriyati, J.; Warif, N.A. Inhibitory effects of xanthones on platelet activating factor receptor binding in vitro. J. Ethnopharmacol. 2001, 75, 287-290. (Pubitemid 32297747)
7. Jantan, I.; Jalil, J.; Warif, N.M.A. Platelet Activating Factor (PAF) antagonistic activities of compounds isolated from Guttiferae species. Pharm. Biol. 2001, 39, 243-246. (Pubitemid 32881507)
8. Hay, A.-E.; Helesbeux, J.-J.; Duval, O.; Labaied, M.; Grellier, P.; Richomme, P. Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii. Life Sci. 2004, 75, 3077-3085. (Pubitemid 39330589)
9. Khan, M.T.H.; Orhan, I.; Senol, F.S.; Kartal, M.; Sener, B.; Dvorska, M.; Smejkal, K.; Slapetova, T. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chem. Biol. Interact. 2009, 181, 383-389.
10. Lee, B.W.; Lee, J.H.; Lee, S.-T.; Lee, H.S.; Lee, W.S.; Jeong, T.-S.; Park, K.H. Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata. Bioorg. Med. Chem. Lett. 2005, 15, 5548-5552. (Pubitemid 41562988)
11. Wabo, H.K.; Kikuchi, H.; Katou, Y.; Tane, P.; Oshima, Y. Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity. Phytochem. Lett. 2010, 3, 104-107.
12. Menasria, F.; Azebaze, A.G.B.; Billard, C.; Faussat, A.M.; Nkengfack, A.E.; Meyer, M.; Kolb, J.P. Apoptotic effects on B-cell chronic lymphocytic leukemia (B-CLL) cells of heterocyclic compounds isolated from Guttiferaes. Leuk. Res. 2008, 32, 1914-1926.
13. Krajarng, A.; Nilwarankoon, S.; Suksamrarn, S.; Watanapokasin, R. Antiproliferative effect of α-mangostin on Canine Osteosarcoma cells. Res. Vet. Sci. 2012, 93, 788-794.
14. Teh, S.S.; Ee, G.C.L.; Rahmani, M.; Sim, W.C.; Mah, S.H.; Teo, S.H. Two new pyranoxanthones from Mesua beccariana. Molecules 2010, 15, 6733-6742.
15. Iinuma, M.; Tosa, H.; Tanaka, T.; Yonemori, S. Two new xanthones in the underground part of Calophyllum inophyllum. Heterocycles 1994, 37, 833-838.
16. Teh, S.S.; Ee, G.C.L.; Rahmani, M.; Yap, Y.H.T.; Go, R.; Mah, S.H. Pyranoxanthones from Mesua ferrea. Molecules 2011, 16, 5647-5654.
17. Ee, G.C.L.; Teh, S.S.; Rahmani, M.; Yap, Y.H.T.; Go, R.; Mah, S.H. A new furanoxanthone from the root bark of Mesua ferrea. Lett. Org. Chem. 2012, 9, 457-459.
18. Iinuma, M.; Tosa, H.; Tanaka, T.; Yonemori, S. Two xanthones from root bark of Calophyllum inophyllum. Phytochemistry 1994, 35, 527-532. (Pubitemid 2036658)
19. Locksley, H.D.; Murray, I.G. Xanthones from the heartwood of Ochrocarpos odoratus. Phytochemistry 1971, 10, 3179-3183.
20. Mesquita, A.A.L.; Oliveira, G.; Neiva, R.M.T. Xanthones from Tovomita pyrifolium. Phytochemistry 1975, 14, 803-806.
21. Yates, P.; Stout, G.H. The Structure of Mangostin. J. Am. Chem. Soc. 1958, 80, 1691-1700.
22. Mosmann, T. Rapid colorimetric assay for cellular growth and survivals: Application to proliferation and cytotoxic assays. J. Immunol. Methods 1983, 65, 55-63. (Pubitemid 14203433)