Retaining antibodies in tumors with a self-assembling injectable system

Molecular Pharmaceutics

Volumn 10, Issue 3, 2013, Pages 1035-1044

  Wen, Yi ^a   Kolonich, Harold R ^a   Kruszewski, Kristen M ^a   Giannoukakis, Nick ^b   Gawalt, Ellen S ^c   Meng, Wilson S ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

Author keywords

EAK16 II; His tags; intratumoral antibody delivery; peptide amphiphiles; stimuli responsive materials

Indexed keywords

EAK16 II PEPTIDE; EAK16 PEPTIDE; IMMUNOGLOBULIN G; PEPTIDE; POLYHISTIDINE TAG; PROTEIN A; PROTEIN G; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BETA SHEET; CONTROLLED STUDY; DRUG CLEARANCE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INJECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

EID: 84874592204     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300504z     Document Type: Article

References (38)

1. Crittenden, M. R.; Thanarajasingam, U.; Vile, R. G.; Gough, M. J. Intratumoral immunotherapy: using the tumour against itself Immunology 2005, 114 (1) 11-22
2. Wang, R. F.; Rosenberg, S. A. Human tumor antigens for cancer vaccine development Immunol. Rev. 1999, 170, 85-100
3. Steinman, R. M. The dendritic cell system and its role in immunogenicity Annu. Rev. Immunol. 1991, 9, 271-96
4. Steinman, R. M.; Hawiger, D.; Nussenzweig, M. C. Tolerogenic dendritic cells Annu. Rev. Immunol. 2003, 21, 685-711
5. Curiel, T. J. Regulatory T cells and treatment of cancer Curr. Opin. Immunol. 2008, 20 (2) 241-6
6. Kilinc, M. O.; Aulakh, K. S.; Nair, R. E.; Jones, S. A.; Alard, P.; Kosiewicz, M. M.; Egilmez, N. K. Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors J. Immunol. 2006, 177 (10) 6962
7. Hanes, J.; Sills, A.; Zhao, Z.; Suh, K. W.; Tyler, B.; DiMeco, F.; Brat, D. J.; Choti, M. A.; Leong, K. W.; Pardoll, D. M. Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors Pharm. Res. 2001, 18 (7) 899-906
8. Hori, Y.; Stern, P. J.; Hynes, R. O.; Irvine, D. J. Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy Biomaterials 2009, 30 (35) 6757-67
9. Hori, Y.; Winans, A. M.; Irvine, D. J. Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors Acta Biomater. 2009, 5 (4) 969-82
10. Yang, R. K.; Kalogriopoulos, N. A.; Rakhmilevich, A. L.; Ranheim, E. A.; Seo, S.; Kim, K. M.; Alderson, K. L.; Gan, J.; Reisfeld, R. A.; Gillies, S. D. Intratumoral hu14.18-IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention J. Immunol. 2012, 189 (5) 2656-64
11. Kim, Y. H.; Gratzinger, D.; Harrison, C.; Brody, J. D.; Czerwinski, D. K.; Ai, W. Z.; Morales, A.; Abdulla, F.; Xing, L.; Navi, D. In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study Blood 2012, 119 (2) 355-63
12. Jain, R. K. Delivery of molecular and cellular medicine to solid tumors J. Controlled Release 1998, 53 (1-3) 49-67
13. Netti, P. A.; Berk, D. A.; Swartz, M. A.; Grodzinsky, A. J.; Jain, R. K. Role of extracellular matrix assembly in interstitial transport in solid tumors Cancer Res. 2000, 60 (9) 2497-503
14. Ravetch, J. V.; Bolland, S. IgG Fc receptors Annu. Rev. Immunol. 2001, 19, 275-90
15. Pritchard, E. M.; Kaplan, D. L. Silk fibroin biomaterials for controlled release drug delivery Expert Opin. Drug Delivery 2011, 8 (6) 797-811
16. Bowerman, C. J.; Nilsson, B. L. Self-assembly of amphipathic beta-sheet peptides: insights and applications Biopolymers 2012, 98 (3) 169-84
17. Sadatmousavi, P.; Soltani, M.; Nazarian, R.; Jafari, M.; Chen, P. Self-Assembling Peptides: Potential Role in Tumor Targeting Curr. Pharm. Biotechnol. 2011, 12 (8) 1089-100
18. Branco, M. C.; Schneider, J. P. Self-assembling materials for therapeutic delivery Acta Biomater. 2009, 5 (3) 817-31
19. Zhang, S.; Marini, D. M.; Hwang, W.; Santoso, S. Design of nanostructured biological materials through self-assembly of peptides and proteins Curr. Opin. Chem. Biol. 2002, 6 (6) 865-71
20. Zhang, S. Fabrication of novel biomaterials through molecular self-assembly Nat. Biotechnol. 2003, 21 (10) 1171-8
21. Holmes, T. C.; de Lacalle, S.; Su, X.; Liu, G.; Rich, A.; Zhang, S. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (12) 6728-33
22. Dasch, J. R.; Pace, D. R.; Avis, P. D.; Bentz, H.; Chu, S. Characterization of monoclonal antibodies recognizing bovine bone osteoglycin Connect. Tissue Res. 1993, 30 (1) 11-21
23. Zheng, Y.; Wen, Y.; George, A. M.; Steinbach, A. M.; Phillips, B. E.; Giannoukakis, N.; Gawalt, E. S.; Meng, W. S. A peptide-based material platform for displaying antibodies to engage T cells Biomaterials 2011, 32 (1) 249-57
24. Dasch, J. R.; Pace, D. R.; Waegell, W.; Inenaga, D.; Ellingsworth, L. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification J. Immunol. 1989, 142 (5) 1536-41
25. McGuire, S.; Zaharoff, D.; Yuan, F. Nonlinear dependence of hydraulic conductivity on tissue deformation during intratumoral infusion Ann. Biomed. Eng. 2006, 34 (7) 1173-81
26. Zhang, S.; Lockshin, C.; Cook, R.; Rich, A. Unusually stable beta-sheet formation in an ionic self-complementary oligopeptide Biopolymers 1994, 34 (5) 663-72
27. Ma, L. L.; Tam, J. O.; Willsey, B. W.; Rigdon, D.; Ramesh, R.; Sokolov, K.; Johnston, K. P. Selective targeting of antibody conjugated multifunctional nanoclusters (nanoroses) to epidermal growth factor receptors in cancer cells Langmuir 2011, 27 (12) 7681-90
28. Aslakson, C. J.; Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor Cancer Res. 1992, 52 (6) 1399-405
29. Poste, G.; Doll, J.; Hart, I. R.; Fidler, I. J. In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties Cancer Res. 1980, 40 (5) 1636-44
30. Peluso, P.; Wilson, D. S.; Do, D.; Tran, H.; Venkatasubbaiah, M.; Quincy, D.; Heidecker, B.; Poindexter, K.; Tolani, N.; Phelan, M.; Witte, K.; Jung, L. S.; Wagner, P.; Nock, S. Optimizing antibody immobilization strategies for the construction of protein microarrays Anal. Biochem. 2003, 312 (2) 113-24
31. Leckband, D. E. The influence of protein and interfacial structure on the self-assembly of oriented protein arrays Adv. Biophys. 1997, 34, 173-90
32. Johnson, C. P.; Jensen, I. E.; Prakasam, A.; Vijayendran, R.; Leckband, D. Engineered protein a for the orientational control of immobilized proteins Bioconjugate Chem. 2003, 14 (5) 974-8
33. Saha, K.; Bender, F.; Gizeli, E. Comparative study of IgG binding to proteins G and A: nonequilibrium kinetic and binding constant determination with the acoustic waveguide device Anal. Chem. 2003, 75 (4) 835-42
34. Boucher, Y.; Brekken, C.; Netti, P. A.; Baxter, L. T.; Jain, R. K. Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents Br. J. Cancer 1998, 78 (11) 1442-8
35. McGuire, S.; Yuan, F. Quantitative analysis of intratumoral infusion of color molecules Am. J. Physiol. 2001, 281 (2) H715-21
36. Ribas, A. Clinical development of the anti-CTLA-4 antibody tremelimumab Semin. Oncol. 2010, 37 (5) 450-4
37. Harris, L. J.; Larson, S. B.; Hasel, K. W.; Day, J.; Greenwood, A.; McPherson, A. The three-dimensional structure of an intact monoclonal antibody for canine lymphoma Nature 1992, 360 (6402) 369-72
38. Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/.