Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-kB and MAP kinase

World Journal of Gastroenterology

Volumn 19, Issue 8, 2013, Pages 1210-1218

  Zuo, Dong Chuan ^a   Choi, Seok ^a   Shahi, Pawan Kumar ^a   Kim, Man Yoo ^a   Park, Chan Guk ^a   Kim, Young Dae ^a   Lee, Jun ^a   Chang, In Yeoup ^a   So, Insuk ^b   Jun, Jae Yeoul ^a  

^a Chosun University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Interstitial cells of Cajal; Lipopolysaccharide; Mitogen activated protein kinases; Nuclear factor B; Small intestine

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL) CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL) IMIDAZOLE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; CATALASE; CYCLOOXYGENASE 2; DACTINOMYCIN; I KAPPA B KINASE BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; SN 50; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; MOUSE; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VOLTAGE CLAMP;

EID: 84874590317     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i8.1210     Document Type: Article

References (34)

1. Huizinga JD, Thuneberg L, Klüppel M, Malysz J, Mikkelsen HB, Bernstein A. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995; 373: 347-349 [PMID: 7530333 DOI: 10.1038/373347a0]
2. Ordög T, Ward SM, Sanders KM. Interstitial cells of cajal generate electrical slow waves in the murine stomach. J Physiol 1999; 518 (Pt 1): 257-269 [PMID: 10373707 DOI: 10.1111/j.1469-7793.1999.0257r.x]
3. Ward SM, Burns AJ, Torihashi S, Sanders KM. Mutation of the protooncogene ckit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 1994; 480 (Pt 1): 91-97 [PMID: 7853230]
4. Beckett EA, Horiguchi K, Khoyi M, Sanders KM, Ward SM. Loss of enteric motor neurotransmission in the gastric fundus of Sl/Sl(d) mice. J Physiol 2002; 543: 871-887 [PMID: 12231645 DOI: 10.1113/jphysiol.2002.021915]
5. Burns AJ, Lomax AE, Torihashi S, Sanders KM, Ward SM. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci USA 1996; 93: 12008-12013 [PMID: 8876253 DOI: 10.1073/pnas.93.21.12008]
6. Ward SM, Beckett EA, Wang X, Baker F, Khoyi M, Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000; 20: 1393-1403 [PMID: 10662830]
7. Maeda H, Yamagata A, Nishikawa S, Yoshinaga K, Kobayashi S, Nishi K, Nishikawa S. Requirement of ckit for development of intestinal pacemaker system. Development 1992; 116: 369-375 [PMID: 1283735]
8. Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, Lorincz A, Pozo MJ, Pasricha PJ, Van de Rijn M, West RB, Sarr MG, Kendrick ML, Cima RR, Dozois EJ, Larson DW, Ordog T, Farrugia G. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2009; 296: G1370-G1381 [PMID: 19372102 DOI: 10.1152/ajpgi.00074.2009]
9. Deitch EA, Xu D, Franko L, Ayala A, Chaudry IH. Evidence favoring the role of the gut as a cytokinegenerating organ in rats subjected to hemorrhagic shock. Shock 1994; 1: 141-145 [PMID: 7749933 DOI: 10.1097/00024382-199402000-00010]
10. Park H, Calrk E, Cullen JJ, Conklin JL. Effect of endotoxin on opossum oesophageal motor function. Neurogastroenterol Motil 2000; 12: 215-221 [PMID: 10867618 DOI: 10.1046/ j.1365-2982.2000.00202.x]
11. van Miert AS, van Duin CT. Endotoxininduced inhibition of gastric emptying rate in the rat. The effect of repeated administration and the influence of some antipyretic agents. Arch Int Pharmacodyn Ther 1980; 246: 19-27 [PMID: 7004366]
12. Wechsung E. [The involvement of prostaglandins in the inhibiting effect of endotoxin on the myoelectric activity of the gastrointestinal system in pigs]. Verh K Acad Geneeskd Belg 1996; 58: 711-738 [PMID: 9157744]
13. Weisbrodt NW, Pressley TA, Li YF, Zembowicz MJ, Higham SC, Zembowicz A, Lodato RF, Moody FG. Decreased ileal muscle contractility and increased NOS II expression induced by lipopolysaccharide. Am J Physiol 1996; 271: G454-G460 [PMID: 8843770]
14. Der T, Bercik P, Donnelly G, Jackson T, Berezin I, Collins SM, Huizinga JD. Interstitial cells of cajal and inflammationinduced motor dysfunction in the mouse small intestine. Gastroenterology 2000; 119: 1590-1599 [PMID: 11113080 DOI: 10.1053/gast.2000.20221]
15. Lu G, Qian X, Berezin I, Telford GL, Huizinga JD, Sarna SK. Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal. Am J Physiol 1997; 273: G1233-G1245 [PMID: 9435548]
16. Wang XY, Berezin I, Mikkelsen HB, Der T, Bercik P, Collins SM, Huizinga JD. Pathology of interstitial cells of Cajal in relation to inflammation revealed by ultrastructure but not immunohistochemistry. Am J Pathol 2002; 160: 1529-1540 [PMID: 11943737 DOI: 10.1016/S0002-9440(10)62579-5]
17. Zuo DC, Choi S, Shahi PK, Kim MY, Park CG, Kim YD, Lee J, Chang IY, Lee HS, Yeom SC, Moon HJ, Seong SY, So I, Jun JY. Action of lipopolysaccharide on interstitial cells of cajal from mouse small intestine. Pharmacology 2012; 90: 151-159 [PMID: 22890360 DOI: 10.1159/000340018]
18. Abreu MT, Fukata M, Arditi M. TLR signaling in the gut in health and disease. J Immunol 2005; 174: 4453-4460 [PMID: 15814663]
19. Kaisho T, Akira S. Tolllike receptor function and signaling. J Allergy Clin Immunol 2006; 117: 979-987; quiz 988 [PMID: 16675322 DOI: 10.1016/j.jaci.2006.02.023]
20. Kawai T, Akira S. Signaling to NF-kappaB by Tolllike receptors. Trends Mol Med 2007; 13: 460-469 [PMID: 18029230 DOI: 10.1016/j.molmed.2007.09.002]
21. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ. TAK1 is a ubiquitindependent kinase of MKK and IKK. Nature 2001; 412: 346-351 [PMID: 11460167 DOI: 10.1038/35085597]
22. Park CG, Kim YD, Kim MY, Kim JS, Choi S, Yeum CH, Parajuli SP, Park JS, Jeong HS, So I, Kim KW, Jun JY. Inhibition of pacemaker currents by nitric oxide via activation of ATPsensitive K+ channels in cultured interstitial cells of Cajal from the mouse small intestine. Naunyn Schmiedebergs Arch Pharmacol 2007; 376: 175-184 [PMID: 17932655 DOI: 10.1007/ s00210-007-0187-1]
23. Rumio C, Besusso D, Arnaboldi F, Palazzo M, Selleri S, Gariboldi S, Akira S, Uematsu S, Bignami P, Ceriani V, Ménard S, Balsari A. Activation of smooth muscle and myenteric plexus cells of jejunum via Tolllike receptor 4. J Cell Physiol 2006; 208: 47-54 [PMID: 16523497 DOI: 10.1002/jcp.20632]
24. Chen CC, Wang JK. p38 but not p44/42 mitogenactivated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol Pharmacol 1999; 55: 481-488 [PMID: 10051531]
25. Huang KT, Kuo L, Liao JC. Lipopolysaccharide activates endothelial nitric oxide synthase through protein tyrosine kinase. Biochem Biophys Res Commun 1998; 245: 33-37 [PMID: 9535778 DOI: 10.1006/bbrc.1998.8384]
26. Luo SF, Wang CC, Chien CS, Hsiao LD, Yang CM. Induction of cyclooxygenase-2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogenactivated protein kinases and nuclear factorkappaB pathways. Cell Signal 2003; 15: 497-509 [PMID: 12639713 DOI: 10.1016/S0898-6568(02)00135-3]
27. Luo SF, Lin WN, Yang CM, Lee CW, Liao CH, Leu YL, Hsiao LD. Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways. Cell Signal 2006; 18: 1201-1211 [PMID: 16278065 DOI: 10.1016/j.cellsig.2005.09.011]
28. Gonzalo S, Grasa L, Hernández LV, Arruebo MP, Plaza MÁ, Murillo MD. Mitogen activated protein kinases blockade improves lipopolysaccharideinduced ileal motor disturbances. Rev Esp Enferm Dig 2012; 104: 305-309 [PMID: 22738700 DOI: 10.4321/S1130-01082012000600004]
29. Torrie LJ, MacKenzie CJ, Paul A, Plevin R. Hydrogen peroxide-mediated inhibition of lipopolysaccharidestimulated inhibitory kappa B kinase activity in rat aortic smooth muscle cells. Br J Pharmacol 2001; 134: 393-401 [PMID: 11564658 DOI: 10.1038/sj.bjp.0704259]
30. Choi S, Yeum CH, Kim YD, Park CG, Kim MY, Park JS, Jeong HS, Kim BJ, So I, Kim KW. Receptor tyrosine and MAP kinase are involved in effects of H(2)O(2) on interstitial cells of Cajal in murine intestine. J Cell Mol Med 2010; 14: 257-266 [PMID: 20414970 DOI: 10.1111/j.1582-4934.2008.00403.x]
31. Coffey MJ, Coles B, O'Donnell VB. Interactions of nitric oxidederived reactive nitrogen species with peroxidases and lipoxygenases. Free Radic Res 2001; 35: 447-464 [PMID: 11767404 DOI: 10.1080/10715760100301471]
32. Goodwin DC, Landino LM, Marnett LJ. Effects of nitric oxide and nitric oxidederived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis. FASEB J 1999; 13: 1121-1136 [PMID: 10385604]
33. Galea E, Feinstein DL. Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP. FASEB J 1999; 13: 2125-2137 [PMID: 10593859]
34. Tetsuka T, Daphna-Iken D, Srivastava SK, Baier LD, Du-Maine J, Morrison AR. Crosstalk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci USA 1994; 91: 12168-12172 [PMID: 7527554 DOI: 10.1073/pnas.91.25.12168]