Atropine for Critical Care Intubation in a Cohort of 264 Children and Reduced Mortality Unrelated to Effects on Bradycardia

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Jones, Peter ^a,b   Peters, Mark J ^a   Pinto da Costa, Nathalia ^b   Kurth, Tobias ^c,d,e   Alberti, Corinne ^b,f   Kessous, Katia ^b   Lode, Noella ^b   Dauger, Stephane ^b,f  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c INSERM   (France)

^d UNIVERSITÉ DE BORDEAUX   (France)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE;

ARTICLE; BRADYCARDIA; CAUSE OF DEATH; CHILD; CHILD HEALTH CARE; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLLOW UP; HEART RATE VARIABILITY; HUMAN; INTENSIVE CARE; INTUBATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEWBORN; OBSERVATIONAL STUDY; PRESCHOOL CHILD; PRESCRIPTION; RISK ASSESSMENT; RISK REDUCTION; SCHOOL CHILD; TREATMENT OUTCOME;

ATROPINE; BRADYCARDIA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CRITICAL CARE; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; PROSPECTIVE STUDIES;

EID: 84874574874     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057478     Document Type: Article

References (32)

1. Jaber S, Amraoui J, Lefrant JY, Arich C, Cohendy R, et al. (2006) Clinical practice and risk factors for immediate complications of endotracheal intubation in the intensive care unit: a prospective, multiple-center study. Crit Care Med 34: 2355-61.
2. Schwartz DE, Matthay MA, Cohen NH, (1995) Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Anesthesiol 82: 367-76.
3. Carroll CL, Spinella PC, Corsi JM, Stoltz P, Zucker AR, (2011) Emergent endotracheal intubations in children: be careful if it's late when you intubate. Pediatr Crit Care Med 11: 343-8.
4. Fastle RK, Roback MG, (2004) Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropine. Pediatr Emerg Care 20: 651-5.
5. Jones P, Dauger S, Peters MJ, (2012) Bradycardia during critical care intubation: mechanisms, significance and atropine. Arch Dis Child 97: 139-44.
6. Leigh MD, McCoy CD, Belton MK, Lewis GB Jr, (1957) Bradycardia following intravenous administration of succinylcholine chloride to infants and children. Anesthesiol 18: 698-702.
7. Shaw CA, Kelleher AA, Gill CP, Murdoch LJ, Stables RH, et al. (2000) Comparison of the incidence of complications at induction and emergence in infants receiving oral atropine vs no premedication. Br J Anaesth (84) (): 174-8.
8. Shorten GD, Bissonnette B, Hartley E, Nelson W, Carr AS, (1995) It is not necessary to administer more than 10 micrograms.kg-1 of atropine to older children before succinylcholine. Can J Anaesth 42: 8-11.
9. Parnis SJ, van der Walt JH, (1994) A national survey of atropine use by Australian anaesthetists. Anaesth Intensive Care 22: 61-5.
10. Wyllie JP. Neonatal endotracheal intubation, (2008) Arch Dis Child Educ Pract Ed. 93: 44-9.
11. Brierley J, Carcillo JA, Choong K, Cornell T, Decaen A, et al. (2009) Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 37: 666-88.
12. Brady AR, Harrison D, Black S, Jones S, Rowan K, et al. (2006) Assessment and optimization of mortality prediction tools for admissions to pediatric intensive care in the United kingdom. Pediatrics 117: 733-42.
13. Chow LT, Chow SS, Anderson RH, Gosling JA, (2001) Autonomic innervation of the human cardiac conduction system: changes from infancy to senility-an immunohistochemical and histochemical analysis. Anat Rec 264: 169-82.
14. D'Agostino RB Jr, (1998) Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 17: 2265-81.
15. Rubin DB, (2007) The design versus the analysis of observational studies for causal effects: parallels with the design of randomized trials. Stat Med 26: 20-36.
16. Jones P Boulekedid R, Dauger S, Kissoon N, Carcillo J, et al. (2012) An international Delphi survey of atropine for critical care intubation by 61 Paediatric Intensivists. Journal of the Intensive Care Society 13: 2-8.
17. Simon L, Trifa M, Mokhtari M, Hamza J, Treluyer JM, (2004) Premedication for tracheal intubation: a prospective survey in 75 neonatal and pediatric intensive care units. Critical Care Medicine 32: 565-8.
18. Venkatesh V, Ponnusamy V, Anandaraj J, Chaudhary R, Malviya M, et al. (2009) Endotracheal intubation in a neonatal population remains associated with a high risk of adverse events. European Journal of Pediatrics 170: 223-7.
19. Taha S, Siddik-Sayyid S, Alameddine M, Wakim C, Dahabra C, et al. (2005) Propofol is superior to thiopental for intubation without muscle relaxants. Can J Anaesth 52: 249-53.
20. Ghanta S, Abdel-Latif ME, Lui K, Ravindranathan H, Awad J, et al. (2007) Propofol compared with the morphine, atropine, and suxamethonium regimen as induction agents for neonatal endotracheal intubation: a randomized, controlled trial. Pediatrics. 119: 1248-55.
21. Oei J, Hari R, Butha T, Lui K, (2002) Facilitation of neonatal nasotracheal intubation with premedication: a randomized controlled trial. J Paediatr Child Health. 38: 146-50.
22. PICAnet. Annual Report of the Paediatric Intensive Care Audit Network, January 2007 to December 2009. 2010: 115.
23. Gayat E, Pirracchio R, Resche-Rigon M, Mebazaa A, Mary JY, et al. (2010) Propensity scores in intensive care and anaesthesiology literature: a systematic review. Intensive Care Medicine 36: 1993-2003.
24. Kurth T, Walker AM, Glynn RJ, Chan KA, Gaziano JM, et al. (2006) Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. American Journal of Epidemiology 163: 262-70.
25. Salata JJ (2007) Autonomic nervous system control of the heart and atrioventricular node conduction. In: Gilmore JP, Zucker IH (eds) Reflex Control of the Circulation, CRC Press, Boca Raton, 67-101.
26. Andriessen P, Janssen BJ, Berendsen RC, Oetomo SB, Wijn PF, et al. (2004) Cardiovascular autonomic regulation in preterm infants: the effect of atropine. Pediatr Res 56: 939-46.
27. Tirel O, Chanavaz C, Bansard JY, Carre F, Ecoffey C, et al. (2005) Effect of remifentanil with and without atropine on heart rate variability and RR interval in children. Anaesthesia 60: 982-9.
28. Saarnivaara L, Kautto UM, Iisalo E, Pihlajamaki K, (1985) Comparison of pharmacokinetic and pharmacodynamic parameters following oral or intramuscular atropine in children. Atropine overdose in two small children. Acta Anaesthesiologica Scandinavica 29: 529-36.
29. Virtanen R, Kanto J, Iisalo E, Iisalo EU, Salo M, (1982) Pharmacokinetic studies on atropine with special reference to age. Acta Anaesthesiologica Scandinavica 26: 297-300.
30. Walsh CK, Krongrad E, (1983) Terminal cardiac electrical activity in pediatric patients. Am J Cardiol 51: 557-61.
31. Thomsen MB, Truin M, van Opstal JM, Beekman JD, Volders PG, et al. (2005) Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization. Basic Res Cardiol 100: 279-87.
32. Kleinman ME, et al. (2010) Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 122: 466-515.