Western pacific ALS-PDC: A prototypical neurodegenerative disorder linked to DNA damage and aberrant proteogenesis?

Frontiers in Neurology

Volumn 3 DEC, Issue , 2012, Pages

  Spencer, Peter S ^a   Fry, Rebecca C ^b   Palmer, Valerie S ^a   Kisby, Glen E ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c Western University of Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; FORMALDEHYDE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLAZOXYMETHANOL; NEUROTOXIN;

ALZHEIMER DISEASE; CYCADOPHYTA; DEGENERATIVE DISEASE; DNA DAMAGE; DNA REPAIR; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; GENE MUTATION; GENOTOXICITY; GUAM; HUMAN; INDONESIA; JAPAN; LIFESTYLE; MOTOR DYSFUNCTION; NERVE CELL DEGENERATION; NONHUMAN; NOTE; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; WESTERN PACIFIC AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM DEMENTIA COMPLEX;

EID: 84874569954     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2012.00180     Document Type: Note

References (5)

1. Kisby, G. E., Fry, R. C.,Lasarev, M. R., Bammler, T. K., Beyer, R. P., Churchwell, M., et al. (2011a). The cycad genotoxin MAM modulates brain cel-lular pathways involved in neurodegenerative dis-ease and cancer in a DNA damage-linked manner. PLoS ONE 6:e20911. doi:10.1371/journal.pone. 0020911
2. Kisby, G., Palmer, V., Lasarev, M., Fry, R., Iordanov, M., Magun, E., et al. (2011b).Does the cycad genotoxin MAM implicated in Guam ALS-PDC in ducedisease-relevant changes in mousebrain that includes olfaction? Commun. Integr. Biol. 4, 731-734
3. Kisby, G.E., and Spencer, P.S. (2011).Is neurodegen-erative disease along-latency response to early-life genotoxin exposure? Int. J. Environ. Res. Public Health 8, 3889-3921
4. Kisby, G.E., Standley, M., Park, T., Olivas, A., Fei, S., Jacob, T., et al. (2006). Proteomic analysis of the genotoxicant methyla-zoxymethanol (MAM) induced changes in the developing cerebellum. J. ProteomeRes. 5, 2656-2665
5. Spencer, P., Fry, R.C., and Kisby, G.E. (2012). Unraveling 50-year-old clues link-ing neurodegeneration and cancer to cycad toxins: are microRNAs commonmediators? Front. Gene. 3:192. doi:10.3389/fgene.2012. 00192