Acylated dolabellane-type diterpenes from Nigella sativa seeds with triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells

Phytochemistry Letters

Volumn 6, Issue 2, 2013, Pages 198-204

  Morikawa, Toshio ^a   Ninomiya, Kiyofumi ^a   Xu, Fengming ^b   Okumura, Naomichi ^a   Matsuda, Hisashi ^b   Muraoka, Osamu ^a   Hayakawa, Takao ^a   Yoshikawa, Masayuki ^b  

^a KINKI UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Black cumin; Dollabellane type diterpene; Nigella sativa; Nigellamine; Ranunculaceae; Triglyceride metabolism promotor

Indexed keywords

DITERPENE; GLUCOSE; NIGELLAMINE A2; NIGELLAMINE A3; NIGELLAMINE A5; NIGELLAMINE B1; NIGELLAMINE B2; NIGELLAMINE B3; NIGELLAMINE D; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLACK CUMIN; CARBON NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BINDING; DRUG ISOLATION; DRUG STRUCTURE; FATTY ACID METABOLISM; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR WEIGHT; NUCLEAR OVERHAUSER EFFECT; OPTICAL ROTATION; PLANT SEED; PRIORITY JOURNAL; STEREOCHEMISTRY;

NIGELLA SATIVA; RANUNCULACEAE;

EID: 84874541703     PISSN: 18743900     EISSN: 18767486     Source Type: Journal    
DOI: 10.1016/j.phytol.2013.01.004     Document Type: Article

References (11)

1. A.A. Ansari, S. Hassan, L. Kenne, Atta-ur-Rahman, and T. Wehler Structural studies on a saponin isolated Nigella sativa Phytochemistry 27 1988 3977 3979
2. S. Bellentani, C. Tiribelli, G. Saccoccio, M. Sodde, N. Fratti, C. De Martin, and G. Cristianini Prevalence of chronic liver disease in the general population of northern Italy: the dionysos study Hepatrogy 20 1994 1442 1449
3. A.Y. El-Hassan, E.M. Ibrahim, F.A. Al-Mulhim, A.A. Nabhan, and M.Y. Chammas Fatty infiltration of the liver: analysis of prevalence, radiological and clinical features and influence on patient management Br. J. Radiol. 65 1992 774 778
4. K.A. El Sayed, S.A. Ross, M.A. El Sohly, M.M. Khalafalla, O.B. Abdel-Halim, and F. Ikegami Effect of different fertilizers on the amino acid, fatty acid, and essential oil composition of Nigella sativa seeds Saudi Pharm. J. 8 2000 175 181
5. S. Enomoto, R. Asano, Y. Iwahori, T. Narui, Y. Okada, A.N.B. Singab, and T. Okuyama Hemotological studies on black cumin oil from the seeds of Nigella sativa L. Biol. Pharm. Bull. 24 2001 307 310
6. P. Marceau, S. Biron, F.S. Hould, S. Marceau, S. Simard, S.N. Thung, and J.G. Kral Liver pathology and the metabolic syndrome X in severe obesity J. Clin. Endocrinol. Metab. 84 1999 1513 1517
7. G. Marchesini, M. Brizi, A.M. Morselli-Labate, G. Bianchi, E. Bugianesi, A.J. McCullough, G. Forlani, and N. Melchionda Association of nonalcoholic fatty liver disease with insulin resistance Am. J. Med. 107 1999 450 455
8. T. Morikawa, F. Xu, Y. Kashima, H. Matsuda, K. Ninomiya, and M. Yoshikawa Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa Org. Lett. 6 2004 869 872
9. 5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin Chem. Pharm. Bull. 52 2004 494 497
10. O. Muraoka, T. Morikawa, Y. Zhang, K. Ninomiya, S. Nakamura, H. Matsuda, and M. Yoshikawa Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cell from Sedum sarmentosum Tetrahedron 65 2009 4142 4148
11. M. Shimizu, K. Shingyouchi, N. Morita, H. Kizu, and T. Tomimori Triterpenoid saponins from Pulsatilla cernua Spreng. I Chem. Pharm. Bull. 26 1978 1666 1671