Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer's patches of mice and orients the immune response towards humoral immunity

Gut Pathogens

Volumn 4, Issue 1, 2012, Pages

  Gao, Fei ^a   Li, Ming ^a   Liu, Yinhui ^a   Gao, Chuanzhou ^a   Wen, Shu ^a   Tang, Li ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cytokines; Immune response; Intestinal dysbacteriosis; Peyer's patches; T lymphocytes

Indexed keywords

EID: 84874489318     PISSN: None     EISSN: 17574749     Source Type: Journal    
DOI: 10.1186/1757-4749-4-19     Document Type: Article

References (10)

1. Diversity of the human intestinal microbial flora. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA, Science 2005 308 1635 1638 10.1126/science.1110591 15831718
2. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR, Proc Natl Acad Sci 2007 104 13780 13785 10.1073/pnas.0706625104 17699621
3. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau P, Roca J, Dore J, Gut 2006 55 205 211 10.1136/gut.2005.073817 16188921
4. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Ott SJ, Musfeldt M, Wenderoth DF, Hampe J, Brant O, Folsch UR, Timmis KN, Schreiber S, Gut 2004 53 685 693 10.1136/gut.2003.025403 15082587
5. Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I). Chandran P, Satthaporn S, Robins A, Eremin O, Surgeon 2003 1 63 75 10.1016/S1479-666X(03)80118-X 15573623
6. Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II). Chandran P, Satthaporn S, Robins A, Eremin O, Surgeon 2003 1 125 136 10.1016/S1479-666X(03)80091-4 15570747
7. Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches. Spahn TW, Herbst H, Rennert PD, Lugering N, Maaser C, Kraft M, Fontana A, Weiner HL, Domschke W, Kucharzik T, Am J Pathol 2002 161 2273 2282 10.1016/S0002-9440(10)64503-8 12466141
8. Hassall's Corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Watanabe N, Wang YH, Lee HK, Ito T, Cao W, Liu YJ, Nature 2005 436 1181 1185 10.1038/nature03886 16121185
9. Induction of colonic regulatory T cells by indigenous clostridium species. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K, Science 2011 331 6015 337 341 10.1126/science.1198469 21205640
10. An integrated view of suppressor T cell subsets in immunoregulation. Jiang H, Chess L, J Clin Invest 2004 114 1198 1208 15520848