메뉴 건너뛰기




Volumn 57, Issue 3, 2013, Pages 1068-1077

Hemorrhagic events in hepatocellular carcinoma patients treated with antiangiogenic therapies

Author keywords

[No Author keywords available]

Indexed keywords

AMSILAROTENE; ANTINEOPLASTIC AGENT; ARSENIC; BEVACIZUMAB; BORTEZOMIB; CAPECITABINE; CHLOROTRIANISENE; CISPLATIN; DOXORUBICIN; ERLOTINIB; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; INTERLEUKIN 2; LAPATINIB; MEGESTROL ACETATE; NGR HTNF; OCTREOTIDE; ORANTINIB; OXALIPLATIN; PLACEBO; SELUMETINIB; SORAFENIB; SUNITINIB; TEGAFUR; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL; VATALANIB;

EID: 84874473718     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26120     Document Type: Article
Times cited : (23)

References (63)
  • 2
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 3
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel AB, Cohen EI, Ocean A, Lehrer D, Goldenberg A, Knox JJ, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008; 26: 2992-2998.
    • (2008) J Clin Oncol , vol.26 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3    Lehrer, D.4    Goldenberg, A.5    Knox, J.J.6
  • 4
    • 60849124241 scopus 로고    scopus 로고
    • Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
    • Thomas MB, Morris JS, Chadha R, Iwasaki M, Kaur H, Lin E, et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 2009; 27: 843-850.
    • (2009) J Clin Oncol , vol.27 , pp. 843-850
    • Thomas, M.B.1    Morris, J.S.2    Chadha, R.3    Iwasaki, M.4    Kaur, H.5    Lin, E.6
  • 6
    • 40949109774 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in USA
    • El-Serag HB. Epidemiology of hepatocellular carcinoma in USA. Hepatol Res 2007; 37(Suppl 2):S88-S94.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • El-Serag, H.B.1
  • 7
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999; 340: 745-750.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 8
    • 79551520348 scopus 로고    scopus 로고
    • Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis
    • Ranpura V, Hapani S, Wu S. Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. JAMA 2011; 305: 487-494.
    • (2011) JAMA , vol.305 , pp. 487-494
    • Ranpura, V.1    Hapani, S.2    Wu, S.3
  • 9
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer 2007; 96: 1788-1795.
    • (2007) Br J Cancer , vol.96 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 10
    • 0142121282 scopus 로고    scopus 로고
    • Bevacizumab, bleeding, thrombosis, and warfarin
    • author reply 3543.
    • Kilickap S, Abali H, Celik I. Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 2003; 21: 3542; author reply 3543.
    • (2003) J Clin Oncol , vol.21 , pp. 3542
    • Kilickap, S.1    Abali, H.2    Celik, I.3
  • 11
    • 0026573978 scopus 로고
    • Prevention of initial variceal hemorrhage
    • Grace ND. Prevention of initial variceal hemorrhage. Gastroenterol Clin North Am 1992; 21: 149-161.
    • (1992) Gastroenterol Clin North Am , vol.21 , pp. 149-161
    • Grace, N.D.1
  • 12
    • 0037336548 scopus 로고    scopus 로고
    • Incidence and natural history of small esophageal varices in cirrhotic patients
    • Merli M, Nicolini G, Angeloni S, Rinaldi V, De Santis A, Merkel C, et al. Incidence and natural history of small esophageal varices in cirrhotic patients. J Hepatol 2003; 38: 266-272.
    • (2003) J Hepatol , vol.38 , pp. 266-272
    • Merli, M.1    Nicolini, G.2    Angeloni, S.3    Rinaldi, V.4    De Santis, A.5    Merkel, C.6
  • 13
    • 0026469124 scopus 로고
    • Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients
    • Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. HEPATOLOGY 1992; 16: 1343-1349.
    • (1992) HEPATOLOGY , vol.16 , pp. 1343-1349
    • Sarin, S.K.1    Lahoti, D.2    Saxena, S.P.3    Murthy, N.S.4    Makwana, U.K.5
  • 14
    • 71149115465 scopus 로고    scopus 로고
    • Clinical significance of worsening portal hypertension during long-term medical treatment in patients with cirrhosis who had been classified as early good-responders on haemodynamic criteria
    • Merkel C, Bolognesi M, Berzigotti A, Amodio P, Cavasin L, Casarotto IM, et al. Clinical significance of worsening portal hypertension during long-term medical treatment in patients with cirrhosis who had been classified as early good-responders on haemodynamic criteria. J Hepatol 2010; 52: 45-53.
    • (2010) J Hepatol , vol.52 , pp. 45-53
    • Merkel, C.1    Bolognesi, M.2    Berzigotti, A.3    Amodio, P.4    Cavasin, L.5    Casarotto, I.M.6
  • 15
    • 0023681215 scopus 로고
    • Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study
    • No authors listed
    • [No authors listed.] Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 1988; 319: 983-989.
    • (1988) N Engl J Med , vol.319 , pp. 983-989
  • 17
    • 34548802928 scopus 로고    scopus 로고
    • Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    • Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. HEPATOLOGY 2007; 46: 922-938.
    • (2007) HEPATOLOGY , vol.46 , pp. 922-938
    • Garcia-Tsao, G.1    Sanyal, A.J.2    Grace, N.D.3    Carey, W.4
  • 18
    • 78650621925 scopus 로고    scopus 로고
    • Benefit of combination beta-blocker and endoscopic treatment to prevent variceal rebleeding: a meta-analysis
    • Funakoshi N, Segalas-Largey F, Duny Y, Oberti F, Valats JC, Bismuth M, et al. Benefit of combination beta-blocker and endoscopic treatment to prevent variceal rebleeding: a meta-analysis. World J Gastroenterol 2010; 16: 5982-5992.
    • (2010) World J Gastroenterol , vol.16 , pp. 5982-5992
    • Funakoshi, N.1    Segalas-Largey, F.2    Duny, Y.3    Oberti, F.4    Valats, J.C.5    Bismuth, M.6
  • 19
    • 0019519367 scopus 로고
    • The course of patients after variceal hemorrhage
    • Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology 1981; 80: 800-809.
    • (1981) Gastroenterology , vol.80 , pp. 800-809
    • Graham, D.Y.1    Smith, J.L.2
  • 20
    • 78349298645 scopus 로고    scopus 로고
    • Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial
    • Abou-Alfa GK, Johnson P, Knox JJ, Capanu M, Davidenko I, Lacava J, et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA 2010; 304: 2154-2160.
    • (2010) JAMA , vol.304 , pp. 2154-2160
    • Abou-Alfa, G.K.1    Johnson, P.2    Knox, J.J.3    Capanu, M.4    Davidenko, I.5    Lacava, J.6
  • 21
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6
  • 23
    • 62449186539 scopus 로고    scopus 로고
    • Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma
    • Escudier B, Szczylik C, Hutson TE, Demkow T, Staehler M, Rolland F, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 1280-1289.
    • (2009) J Clin Oncol , vol.27 , pp. 1280-1289
    • Escudier, B.1    Szczylik, C.2    Hutson, T.E.3    Demkow, T.4    Staehler, M.5    Rolland, F.6
  • 24
    • 79960805810 scopus 로고    scopus 로고
    • Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma
    • Kudo M, Imanaka K, Chida N, Nakachi K, Tak WY, Takayama T, et al. Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma. Eur J Cancer 2010; 47: 2117-2127.
    • (2010) Eur J Cancer , vol.47 , pp. 2117-2127
    • Kudo, M.1    Imanaka, K.2    Chida, N.3    Nakachi, K.4    Tak, W.Y.5    Takayama, T.6
  • 25
  • 26
    • 77950546450 scopus 로고    scopus 로고
    • Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: a Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase II trial (SAKK 77/06)
    • Koeberle D, Montemurro M, Samaras P, Majno P, Simcock M, Limacher A, et al. Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: a Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase II trial (SAKK 77/06). Oncologist 2010; 15: 285-292.
    • (2010) Oncologist , vol.15 , pp. 285-292
    • Koeberle, D.1    Montemurro, M.2    Samaras, P.3    Majno, P.4    Simcock, M.5    Limacher, A.6
  • 27
    • 78649972858 scopus 로고    scopus 로고
    • Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study
    • Dufour JF, Hoppe H, Heim MH, Helbling B, Maurhofer O, Szucs-Farkas Z, et al. Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study. Oncologist 2010; 15: 1198-1204.
    • (2010) Oncologist , vol.15 , pp. 1198-1204
    • Dufour, J.F.1    Hoppe, H.2    Heim, M.H.3    Helbling, B.4    Maurhofer, O.5    Szucs-Farkas, Z.6
  • 28
    • 79953803472 scopus 로고    scopus 로고
    • A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
    • Kanai F, Yoshida H, Tateishi R, Sato S, Kawabe T, Obi S, et al. A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol 2011; 67: 315-324.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 315-324
    • Kanai, F.1    Yoshida, H.2    Tateishi, R.3    Sato, S.4    Kawabe, T.5    Obi, S.6
  • 29
    • 67649946279 scopus 로고    scopus 로고
    • Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study
    • Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol 2009; 27: 3027-3035.
    • (2009) J Clin Oncol , vol.27 , pp. 3027-3035
    • Zhu, A.X.1    Sahani, D.V.2    Duda, D.G.3    di Tomaso, E.4    Ancukiewicz, M.5    Catalano, O.A.6
  • 30
    • 67651165187 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study
    • Faivre S, Raymond E, Boucher E, Douillard J, Lim HY, Kim JS, et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol 2009; 10: 794-800.
    • (2009) Lancet Oncol , vol.10 , pp. 794-800
    • Faivre, S.1    Raymond, E.2    Boucher, E.3    Douillard, J.4    Lim, H.Y.5    Kim, J.S.6
  • 31
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP, Clark JW, Muzikansky A, Horgan K, et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006; 24: 1898-1903.
    • (2006) J Clin Oncol , vol.24 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3    Clark, J.W.4    Muzikansky, A.5    Horgan, K.6
  • 32
    • 84984578313 scopus 로고    scopus 로고
    • Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
    • Hsu CH, Yang TS, Hsu C, Toh HC, Epstein RJ, Hsiao LT, et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer 2010; 102: 981-986.
    • (2010) Br J Cancer , vol.102 , pp. 981-986
    • Hsu, C.H.1    Yang, T.S.2    Hsu, C.3    Toh, H.C.4    Epstein, R.J.5    Hsiao, L.T.6
  • 33
    • 36949033865 scopus 로고    scopus 로고
    • Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma
    • Furuse J, Ishii H, Nakachi K, Suzuki E, Shimizu S, Nakajima K. Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Sci 2008; 99: 159-165.
    • (2008) Cancer Sci , vol.99 , pp. 159-165
    • Furuse, J.1    Ishii, H.2    Nakachi, K.3    Suzuki, E.4    Shimizu, S.5    Nakajima, K.6
  • 34
    • 67651095716 scopus 로고    scopus 로고
    • Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis
    • Worns MA, Weinmann A, Pfingst K, Schulte-Sasse C, Messow CM, Schulze-Bergkamen H, et al. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. J Clin Gastroenterol 2009; 43: 489-495.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 489-495
    • Worns, M.A.1    Weinmann, A.2    Pfingst, K.3    Schulte-Sasse, C.4    Messow, C.M.5    Schulze-Bergkamen, H.6
  • 35
    • 78249288161 scopus 로고    scopus 로고
    • Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma
    • Yau T, Chan P, Pang R, Ng K, Fan ST, Poon RT. Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma. Cancer 2010; 116: 5022-5029.
    • (2010) Cancer , vol.116 , pp. 5022-5029
    • Yau, T.1    Chan, P.2    Pang, R.3    Ng, K.4    Fan, S.T.5    Poon, R.T.6
  • 36
    • 77956438555 scopus 로고    scopus 로고
    • Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma
    • Santoro A, Pressiani T, Citterio G, Rossoni G, Donadoni G, Pozzi F, et al. Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma. Br J Cancer 2010; 103: 837-844.
    • (2010) Br J Cancer , vol.103 , pp. 837-844
    • Santoro, A.1    Pressiani, T.2    Citterio, G.3    Rossoni, G.4    Donadoni, G.5    Pozzi, F.6
  • 37
    • 77953124105 scopus 로고    scopus 로고
    • Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
    • Hsu CH, Shen YC, Lin ZZ, Chen PJ, Shao YY, Ding YH, et al. Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. J Hepatol 2010; 53: 126-131.
    • (2010) J Hepatol , vol.53 , pp. 126-131
    • Hsu, C.H.1    Shen, Y.C.2    Lin, Z.Z.3    Chen, P.J.4    Shao, Y.Y.5    Ding, Y.H.6
  • 38
    • 77956228586 scopus 로고    scopus 로고
    • Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: multicenter phase II So.LAR. study
    • Prete SD, Montella L, Caraglia M, Maiorino L, Cennamo G, Montesarchio V, et al. Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: multicenter phase II So.LAR. study. Cancer Chemother Pharmacol 2010; 66: 837-844.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 837-844
    • Prete, S.D.1    Montella, L.2    Caraglia, M.3    Maiorino, L.4    Cennamo, G.5    Montesarchio, V.6
  • 39
    • 59449089100 scopus 로고    scopus 로고
    • Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response
    • Yau T, Chan P, Ng KK, Chok SH, Cheung TT, Fan ST, et al. Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response. Cancer 2009; 115: 428-436.
    • (2009) Cancer , vol.115 , pp. 428-436
    • Yau, T.1    Chan, P.2    Ng, K.K.3    Chok, S.H.4    Cheung, T.T.5    Fan, S.T.6
  • 40
    • 60449093312 scopus 로고    scopus 로고
    • Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial
    • Richly H, Schultheis B, Adamietz IA, Kupsch P, Grubert M, Hilger RA, et al. Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial. Eur J Cancer 2009; 45: 579-587.
    • (2009) Eur J Cancer , vol.45 , pp. 579-587
    • Richly, H.1    Schultheis, B.2    Adamietz, I.A.3    Kupsch, P.4    Grubert, M.5    Hilger, R.A.6
  • 41
    • 23044481855 scopus 로고    scopus 로고
    • Effects of the combined treatment with thalidomide, megestrol and interleukine-2 in cirrhotic patients with advanced hepatocellular carcinoma. A pilot study
    • Cappa FM, Cantarini MC, Magini G, Zambruni A, Bendini C, Santi V, et al. Effects of the combined treatment with thalidomide, megestrol and interleukine-2 in cirrhotic patients with advanced hepatocellular carcinoma. A pilot study. Dig Liver Dis 2005; 37: 254-259.
    • (2005) Dig Liver Dis , vol.37 , pp. 254-259
    • Cappa, F.M.1    Cantarini, M.C.2    Magini, G.3    Zambruni, A.4    Bendini, C.5    Santi, V.6
  • 42
    • 77955796298 scopus 로고    scopus 로고
    • A phase II (PhII) trial of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (c.i.) in patients (pts) with advanced hepatocellular carcinoma (HCC): Preliminary data
    • Petrini I, Lencioni M, Ricasoli M, Iannopollo M, Orlandini C, Oliveri F, et al. A phase II (PhII) trial of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (c.i.) in patients (pts) with advanced hepatocellular carcinoma (HCC): Preliminary data. J Clin Oncol (Meeting Abstracts) 2009; 27: 4592.
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 4592
    • Petrini, I.1    Lencioni, M.2    Ricasoli, M.3    Iannopollo, M.4    Orlandini, C.5    Oliveri, F.6
  • 44
    • 84866732712 scopus 로고    scopus 로고
    • Gemcitabine and docetaxel for hepatocellular carcinoma: a phase II North Central Cancer Treatment Group Clinical Trial
    • Alberts SR, Reid JM, Morlan BW, Farr GH, Camoriano JK, Johnson DB, et al. Gemcitabine and docetaxel for hepatocellular carcinoma: a phase II North Central Cancer Treatment Group Clinical Trial. Am J Clin Oncol 2012; 35: 418-425.
    • (2012) Am J Clin Oncol , vol.35 , pp. 418-425
    • Alberts, S.R.1    Reid, J.M.2    Morlan, B.W.3    Farr, G.H.4    Camoriano, J.K.5    Johnson, D.B.6
  • 45
    • 79959214127 scopus 로고    scopus 로고
    • Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma
    • O'Neil BH, Goff LW, Kauh JS, Strosberg JR, Bekaii-Saab TS, Lee RM, et al. Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2010; 29: 2350-2356.
    • (2010) J Clin Oncol , vol.29 , pp. 2350-2356
    • O'Neil, B.H.1    Goff, L.W.2    Kauh, J.S.3    Strosberg, J.R.4    Bekaii-Saab, T.S.5    Lee, R.M.6
  • 46
    • 78650686796 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin and gemcitabine in patients with advanced hepatocellular carcinoma: results of a phase 2 study
    • Lombardi G, Zustovich F, Farinati F, Cillo U, Vitale A, Zanus G, et al. Pegylated liposomal doxorubicin and gemcitabine in patients with advanced hepatocellular carcinoma: results of a phase 2 study. Cancer 2010; 117: 125-133.
    • (2010) Cancer , vol.117 , pp. 125-133
    • Lombardi, G.1    Zustovich, F.2    Farinati, F.3    Cillo, U.4    Vitale, A.5    Zanus, G.6
  • 47
    • 78449287526 scopus 로고    scopus 로고
    • Phase I/II study of the pharmacokinetics, safety and efficacy of S-1 in patients with advanced hepatocellular carcinoma
    • Furuse J, Okusaka T, Kaneko S, Kudo M, Nakachi K, Ueno H, et al. Phase I/II study of the pharmacokinetics, safety and efficacy of S-1 in patients with advanced hepatocellular carcinoma. Cancer Sci 2010; 101: 2606-2611.
    • (2010) Cancer Sci , vol.101 , pp. 2606-2611
    • Furuse, J.1    Okusaka, T.2    Kaneko, S.3    Kudo, M.4    Nakachi, K.5    Ueno, H.6
  • 48
    • 84856554756 scopus 로고    scopus 로고
    • An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma
    • Kim GP, Mahoney MR, Szydlo D, Mok TS, Marshke R, Holen K, et al. An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma. Invest New Drugs 2010; 30: 387-394.
    • (2010) Invest New Drugs , vol.30 , pp. 387-394
    • Kim, G.P.1    Mahoney, M.R.2    Szydlo, D.3    Mok, T.S.4    Marshke, R.5    Holen, K.6
  • 49
    • 77957245576 scopus 로고    scopus 로고
    • A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
    • Yang TS, Lu SN, Chao Y, Sheen IS, Lin CC, Wang TE, et al. A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients. Br J Cancer 2010; 103: 954-960.
    • (2010) Br J Cancer , vol.103 , pp. 954-960
    • Yang, T.S.1    Lu, S.N.2    Chao, Y.3    Sheen, I.S.4    Lin, C.C.5    Wang, T.E.6
  • 50
    • 77953963578 scopus 로고    scopus 로고
    • A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
    • Greten TF, Forner A, Korangy F, N'Kontchou G, Barget N, Ayuso C, et al. A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer 2010; 10: 209.
    • (2010) BMC Cancer , vol.10 , pp. 209
    • Greten, T.F.1    Forner, A.2    Korangy, F.3    N'Kontchou, G.4    Barget, N.5    Ayuso, C.6
  • 51
    • 77952316981 scopus 로고    scopus 로고
    • Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma
    • Glazer ES, Piccirillo M, Albino V, Di Giacomo R, Palaia R, Mastro AA, et al. Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol 2010; 28: 2220-2226.
    • (2010) J Clin Oncol , vol.28 , pp. 2220-2226
    • Glazer, E.S.1    Piccirillo, M.2    Albino, V.3    Di Giacomo, R.4    Palaia, R.5    Mastro, A.A.6
  • 52
    • 70349443677 scopus 로고    scopus 로고
    • A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas
    • Bekaii-Saab T, Markowitz J, Prescott N, Sadee W, Heerema N, Wei L, et al. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin Cancer Res 2009; 15: 5895-5901.
    • (2009) Clin Cancer Res , vol.15 , pp. 5895-5901
    • Bekaii-Saab, T.1    Markowitz, J.2    Prescott, N.3    Sadee, W.4    Heerema, N.5    Wei, L.6
  • 53
    • 33750445933 scopus 로고    scopus 로고
    • Arsenic trioxide in patients with hepatocellular carcinoma: a phase II trial
    • Lin CC, Hsu C, Hsu CH, Hsu WL, Cheng AL, Yang CH. Arsenic trioxide in patients with hepatocellular carcinoma: a phase II trial. Invest New Drugs 2007; 25: 77-84.
    • (2007) Invest New Drugs , vol.25 , pp. 77-84
    • Lin, C.C.1    Hsu, C.2    Hsu, C.H.3    Hsu, W.L.4    Cheng, A.L.5    Yang, C.H.6
  • 54
    • 55449136168 scopus 로고    scopus 로고
    • Phase II study of oxaliplatin in patients with unresectable, metastatic, or recurrent hepatocellular cancer: a California Cancer Consortium Trial
    • Yen Y, Lim DW, Chung V, Morgan RJ, Leong LA, Shibata SI, et al. Phase II study of oxaliplatin in patients with unresectable, metastatic, or recurrent hepatocellular cancer: a California Cancer Consortium Trial. Am J Clin Oncol 2008; 31: 317-322.
    • (2008) Am J Clin Oncol , vol.31 , pp. 317-322
    • Yen, Y.1    Lim, D.W.2    Chung, V.3    Morgan, R.J.4    Leong, L.A.5    Shibata, S.I.6
  • 55
    • 61449234114 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma
    • Uhm JE, Park JO, Lee J, Park YS, Park SH, Yoo BC, et al. A phase II study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma. Cancer Chemother Pharmacol 2009; 63: 929-935.
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 929-935
    • Uhm, J.E.1    Park, J.O.2    Lee, J.3    Park, Y.S.4    Park, S.H.5    Yoo, B.C.6
  • 56
    • 49449104680 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine in combination with cisplatin in inoperable or advanced hepatocellular carcinoma
    • Chia WK, Ong S, Toh HC, Hee SW, Choo SP, Poon DY, et al. Phase II trial of gemcitabine in combination with cisplatin in inoperable or advanced hepatocellular carcinoma. Ann Acad Med Singapore 2008; 37: 554-558.
    • (2008) Ann Acad Med Singapore , vol.37 , pp. 554-558
    • Chia, W.K.1    Ong, S.2    Toh, H.C.3    Hee, S.W.4    Choo, S.P.5    Poon, D.Y.6
  • 57
    • 54949158472 scopus 로고    scopus 로고
    • A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma
    • Higginbotham KB, Lozano R, Brown T, Patt YZ, Arima T, Abbruzzese JL, et al. A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma. J Cancer Res Clin Oncol 2008; 134: 1325-1335.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 1325-1335
    • Higginbotham, K.B.1    Lozano, R.2    Brown, T.3    Patt, Y.Z.4    Arima, T.5    Abbruzzese, J.L.6
  • 58
    • 48049120897 scopus 로고    scopus 로고
    • Chemotherapy with etoposide, doxorubicin, cisplatin, 5-fluorouracil, and leucovorin for patients with advanced hepatocellular carcinoma
    • Yuan JN, Chao Y, Lee WP, Li CP, Lee RC, Chang FY, et al. Chemotherapy with etoposide, doxorubicin, cisplatin, 5-fluorouracil, and leucovorin for patients with advanced hepatocellular carcinoma. Med Oncol 2008; 25: 201-206.
    • (2008) Med Oncol , vol.25 , pp. 201-206
    • Yuan, J.N.1    Chao, Y.2    Lee, W.P.3    Li, C.P.4    Lee, R.C.5    Chang, F.Y.6
  • 59
    • 69249105577 scopus 로고    scopus 로고
    • A Phase II study of 5-fluorouracil and cisplatin systemic chemotherapy for inoperable hepatocellular carcinoma with alpha fetoprotein as a predictive and prognostic marker
    • Keam B, Oh DY, Lee SH, Kim DW, Im SA, Kim TY, et al. A Phase II study of 5-fluorouracil and cisplatin systemic chemotherapy for inoperable hepatocellular carcinoma with alpha fetoprotein as a predictive and prognostic marker. Mol Med Report 2008; 1: 415-422.
    • (2008) Mol Med Report , vol.1 , pp. 415-422
    • Keam, B.1    Oh, D.Y.2    Lee, S.H.3    Kim, D.W.4    Im, S.A.5    Kim, T.Y.6
  • 60
    • 46049097410 scopus 로고    scopus 로고
    • Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study
    • Asnacios A, Fartoux L, Romano O, Tesmoingt C, Louafi SS, Mansoubakht T, et al. Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study. Cancer 2008; 112: 2733-2739.
    • (2008) Cancer , vol.112 , pp. 2733-2739
    • Asnacios, A.1    Fartoux, L.2    Romano, O.3    Tesmoingt, C.4    Louafi, S.S.5    Mansoubakht, T.6
  • 61
    • 42449109133 scopus 로고    scopus 로고
    • Phase II study of imatinib in unresectable hepatocellular carcinoma
    • Lin AY, Fisher GA, So S, Tang C, Levitt L. Phase II study of imatinib in unresectable hepatocellular carcinoma. Am J Clin Oncol 2008; 31: 84-88.
    • (2008) Am J Clin Oncol , vol.31 , pp. 84-88
    • Lin, A.Y.1    Fisher, G.A.2    So, S.3    Tang, C.4    Levitt, L.5
  • 62
    • 45849097147 scopus 로고    scopus 로고
    • A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma
    • Cohn AL, Myers JW, Mamus S, Deur C, Nicol S, Hood K, et al. A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma. Invest New Drugs 2008; 26: 381-386.
    • (2008) Invest New Drugs , vol.26 , pp. 381-386
    • Cohn, A.L.1    Myers, J.W.2    Mamus, S.3    Deur, C.4    Nicol, S.5    Hood, K.6
  • 63
    • 42549084401 scopus 로고    scopus 로고
    • A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168)
    • Knox JJ, Gill S, Synold TW, Biagi JJ, Major P, Feld R, et al. A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168). Invest New Drugs 2008; 26: 265-272.
    • (2008) Invest New Drugs , vol.26 , pp. 265-272
    • Knox, J.J.1    Gill, S.2    Synold, T.W.3    Biagi, J.J.4    Major, P.5    Feld, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.