Mef2c Regulates Transcription of the Extracellular Matrix Protein Cartilage Link Protein 1 in the Developing Murine Heart

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Lockhart, Marie M ^a   Wirrig, Elaine E ^b   Phelps, Aimee L ^a   Ghatnekar, Angela V ^a   Barth, Jeremy L ^a   Norris, Russell A ^a   Wessels, Andy ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE LINK PROTEIN 1; MESSENGER RNA; SCLEROPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MEF2C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CRTL1 GENE; DNA FLANKING REGION; EMBRYO; GENE; GENE EXPRESSION REGULATION; HEART DEVELOPMENT; MITRAL VALVE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SEQUENCE ALIGNMENT; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; ENDOCARDIUM; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; MICE; MOLECULAR SEQUENCE DATA; MYOCARDIUM; MYOGENIC REGULATORY FACTORS; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEOGLYCANS; SEQUENCE ALIGNMENT; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84874471608     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057073     Document Type: Article

References (36)

1. Carulli D, Pizzorusso T, Kwok JC, Putignano E, Poli A, et al. (2010) Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain: a journal of neurology 133: 2331-2347.
2. Wirrig EE, Snarr BS, Chintalapudi MR, O'Neal J L, Phelps AL, et al. (2007) Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Developmental biology 310: 291-303.
3. Watanabe H, Yamada Y, (1999) Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nature genetics 21: 225-229.
4. Seyfried NT, McVey GF, Almond A, Mahoney DJ, Dudhia J, et al. (2005) Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. The Journal of biological chemistry 280: 5435-5448.
5. Matsumoto K, Kamiya N, Suwan K, Atsumi F, Shimizu K, et al. (2006) Identification and characterization of versican/PG-M aggregates in cartilage. The Journal of biological chemistry 281: 18257-18263.
6. Miwa HE, Gerken TA, Huynh TD, Flory DM, Hering TM, (2006) Mammalian expression of full-length bovine aggrecan and link protein: formation of recombinant proteoglycan aggregates and analysis of proteolytic cleavage by ADAMTS-4 and MMP-13. Biochimica et biophysica acta 1760: 472-486.
7. Rodriguez E, Roughley P, (2006) Link protein can retard the degradation of hyaluronan in proteoglycan aggregates. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society 14: 823-829.
8. Combs MD, Yutzey KE, (2009) Heart valve development: regulatory networks in development and disease. Circulation research 105: 408-421.
9. Lincoln J, Lange AW, Yutzey KE, (2006) Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Developmental biology 294: 292-302.
10. Kou I, Ikegawa S, (2004) SOX9-dependent and-independent transcriptional regulation of human cartilage link protein. The Journal of biological chemistry 279: 50942-50948.
11. Peacock JD, Levay AK, Gillaspie DB, Tao G, Lincoln J, (2010) Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circulation research 106: 712-719.
12. Lincoln J, Kist R, Scherer G, Yutzey KE, (2007) Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Developmental biology 305: 120-132.
13. Dy P, Wang W, Bhattaram P, Wang Q, Wang L, et al. (2012) Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Developmental cell 22: 597-609.
14. Leung VY, Gao B, Leung KK, Melhado IG, Wynn SL, et al. (2011) SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS genetics 7: e1002356.
15. Arnold MA, Kim Y, Czubryt MP, Phan D, McAnally J, et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Developmental cell 12: 377-389.
16. Black BL, Olson EN, (1998) Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annual review of cell and developmental biology 14: 167-196.
17. Lemonnier M, Buckingham ME, (2004) Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart. The Journal of biological chemistry 279: 55651-55658.
18. Lee Y, Nadal-Ginard B, Mahdavi V, Izumo S, (1997) Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene. Molecular and cellular biology 17: 2745-2755.
19. Lin Q, Schwarz J, Bucana C, Olson EN, (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276: 1404-1407.
20. Lassmann T, Sonnhammer EL, (2006) Kalign, Kalignvu and Mumsa: web servers for multiple sequence alignment. Nucleic acids research 34: W596-599.
21. Waller BR 3rd, Wessels A, (2000) Cardiac morphogenesis and dysmorphogenesis. An immunohistochemical approach. Methods in molecular biology 135: 151-161.
22. Neame PJ, Christner JE, Baker JR, (1986) The primary structure of link protein from rat chondrosarcoma proteoglycan aggregate. The Journal of biological chemistry 261: 3519-3535.
23. Caterson B, Christner JE, Baker JR, Couchman JR, (1985) Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans. Federation proceedings 44: 386-393.
24. Norris RA, Kern CB, Wessels A, Wirrig EE, Markwald RR, et al. (2005) Detection of betaig-H3, a TGFbeta induced gene, during cardiac development and its complementary pattern with periostin. Anatomy and embryology 210: 13-23.
25. Gossett LA, Kelvin DJ, Sternberg EA, Olson EN, (1989) A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Molecular and cellular biology 9: 5022-5033.
26. Ghatnekar A, Trojanowska M, (2008) GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts. Biochimica et biophysica acta 1779: 145-151.
27. Rhodes C, Yamada Y, (1995) Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene. Nucleic acids research 23: 2305-2313.
28. Potthoff MJ, Olson EN, (2007) MEF2: a central regulator of diverse developmental programs. Development 134: 4131-4140.
29. Cserjesi P, Olson EN, (1991) Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products. Molecular and cellular biology 11: 4854-4862.
30. Peacock JD, Huk DJ, Ediriweera HN, Lincoln J, (2011) Sox9 transcriptionally represses spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PloS one 6: e26769.
31. Camenisch TD, Biesterfeldt J, Brehm-Gibson T, Bradley J, McDonald JA, (2001) Regulation of cardiac cushion development by hyaluronan. Experimental and clinical cardiology 6: 4-10.
32. Mjaatvedt CH, Yamamura H, Capehart AA, Turner D, Markwald RR, (1998) The Cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation. Developmental biology 202: 56-66.
33. Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA, (2002) Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nature medicine 8: 850-855.
34. Kruithof BP, Krawitz SA, Gaussin V, (2007) Atrioventricular valve development during late embryonic and postnatal stages involves condensation and extracellular matrix remodeling. Developmental biology 302: 208-217.
35. Azhar M, Brown K, Gard C, Chen H, Rajan S, et al. (2011) Transforming growth factor Beta2 is required for valve remodeling during heart development. Developmental dynamics: an official publication of the American Association of Anatomists 240: 2127-2141.
36. Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, et al. (2000) Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. The Journal of clinical investigation 106: 349-360.