Epithelial-mesenchymal transformation-mediated lymph node metastasis of oral squamous cell carcinoma and its mechanism

Chinese Journal of Clinical Oncology

Volumn 39, Issue 23, 2012, Pages

  Wang, Bo ^a   Zhang, Chuanping ^b   Zhang, Shu ^a   Yue, Kai ^a   Wang, Xudong ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b PEOPLE S HOSPITAL OF RIZHAO   (China)

Author keywords

CXCR4; Epithelial mesenchymal transformation; Lymph node metastasis; Oral tumors; Squamous cell carcinoma

Indexed keywords

BETA CATENIN; CHEMOKINE RECEPTOR CXCR4; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UVOMORULIN;

ARTICLE; CANCER LOCALIZATION; CANCER STAGING; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION;

EID: 84874467129     PISSN: 10008179     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1000-8179.2012.23.003     Document Type: Article

References (14)

1. Zhang ZC, Neiva KG, Polverini PJ, et al. Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma[J]. J Oral Pathol Med, 2012(41):124-130.
2. Jing Y, Han Z, Zhang S, et al. Epithelial-Mesenchymal Transition in tumor microenvironmen[J]. Cell Biosci, 2011, 31(1):29.
3. Yu L, Li HZ, Lu SM, et al. Down-reguladon of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-Cadherin, N-Cadherin expression[J]. J Cancer Res Clin Oncol, 2011, 137(10):1487-1493.
4. Tanaka N, Odajima T, Ogi K, et al. Expression of E-Cadherin, a-catenin, and b-catenin in the process of lymph node metastasis in oral squamous cell carcinoma[J]. Br J Cancer, 2003, 89(3):557-563. (Pubitemid 37026443)
5. Wushou A, Pan HY, Liu W, et al. Correlation of increased twist with lymph node metastasis in patients with oral squamous cell carcinoma[J]. J Oral Maxillofac Surg, 2012, 6(70):1473-1479.
6. Nijkamp MM, Span PN, Hoogsteen IJ, et al. Expression of E-Cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients[J]. Radiothe oncol, 2011, 99(3):344-348.
7. Nguyen PT, Kudo Y, Yoshida M, et al. N-Cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial- mesenchymal transition[J]. Histol Histopathol, 2011, 26(2):147-156.
8. Fresno Vara JA, Casado E, de Castro J, et al. PI3K/Akt signalling pathway and cancer[J]. Cancer Treat Rev, 2004, 30(2):193-204.
9. Taki M, Verschueren K, Yokoyama K, et al. Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchy-mal transition human squamous carcinoma Cells[J]. Int J Oncol, 2006, 28(2):487-496.
10. Onder TT, Gupta PB, Mani SA, et al. Loss of E-Cadherin promotes metastasis via multipledownstream transcriptional pathways[J].Cancer Res, 2008, 68(10):3645-3654.
11. Onoue T, Uchida D, Begum NM, et al. Epithelial-mesenchymal transition induced the sromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma Cells[J]. Int J Oncol, 2006, 29(5):1133-1148.
12. Wang J, Cai J, Han F, et al. Silencing of CXCR4 Blocks Progression of Ovarian Cancer and Depresses Canonical Wnt Signaling Pathway[J]. Int J Gynecol Cancer, 2011, 21(6):981-987.