Hubs of brain functional networks are radically reorganized in comatose patients

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 50, 2012, Pages 20608-20613

  Achard, Sophie ^a   Delon Martin, Chantal ^b,c   Vértes, Petra E ^d   Renard, Félix ^a   Schenck, Maleka ^e   Schneider, Francis ^e   Heinrich, Christian ^f   Kremer, Stéphane ^e   Bullmore, Edward T ^d,g,h  

^a CNRS   (France)

^b GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^c UNIV GRENOBLE ALPES   (France)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e HÔPITAL DE HAUTEPIERRE   (France)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

^h GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Brain injury; Connectome; Consciousness disorders; Neuroimaging; Wavelet

Indexed keywords

ADULT; AGED; ANATOMICAL VARIATION; ARTICLE; BRAIN CORTEX; BRAIN REGION; CLINICAL ARTICLE; COMA; COMATOSE PATIENT; CONSCIOUSNESS; CONTROLLED STUDY; DISEASE SEVERITY; EVIDENCE BASED PRACTICE; FEMALE; FUNCTIONAL CONNECTIVITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUB; HUMAN; MALE; NEUROMODULATION; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RESTING STATE NETWORK; WAVELET ANALYSIS; BIOLOGICAL MODEL; BRAIN; BRAIN INJURY; CASE CONTROL STUDY; MIDDLE AGED; NERVE CELL NETWORK; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; BRAIN INJURIES; CASE-CONTROL STUDIES; COMA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MODELS, NEUROLOGICAL; NERVE NET; YOUNG ADULT;

EID: 84874437705     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208933109     Document Type: Article

References (39)

1. Achard S, Salvador R, Whitcher B, Suckling J, Bullmore E (2006) A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J Neurosci 26(1):63–72.
2. Bullmore ET, Bassett DS (2011) Brain graphs: Graphical models of the human brain connectome. Annu Rev Clin Psychol 7:113–140.
3. Bullmore E, Sporns O (2009) Complex brain networks: Graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10(3):186–198.
4. Sporns O, Honey CJ, Kötter R (2007) Identification and classification of hubs in brain networks. PLoS ONE 2(10):e1049.
5. Bassett DS, et al. (2010) Efficient physical embedding of topologically complex information processing networks in brains and computer circuits. PLOS Comput Biol 6(4):e1000748.
6. Laureys S, Lemaire C, Maquet P, Phillips C, Franck G (1999) Cerebral metabolism during vegetative state and after recovery to consciousness. J Neurol Neurosurg Psychiatry 67(1):121.
7. Laureys S, Owen AM, Schiff ND (2004) Brain function in coma, vegetative state, and related disorders. Lancet Neurol 3(9):537–546.
8. Giacino JT, Hirsch J, Schiff N, Laureys S (2006) Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness. Arch Phys Med Rehabil 87(12, Suppl 2):S67–S76.
9. Schiff ND, et al. (2005) fMRI reveals large-scale network activation in minimally conscious patients. Neurology 64(3):514–523.
10. Laureys S, et al. (2000) Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 355(9217):1790–1791.
11. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8(9):700–711.
12. Cauda F, et al. (2009) Disrupted intrinsic functional connectivity in the vegetative state. J Neurol Neurosurg Psychiatry 80(4):429–431.
13. Boly M, Massimini M, Tononi G (2009) Theoretical approaches to the diagnosis of altered states of consciousness. Prog Brain Res 177:383–398.
14. Vanhaudenhuyse A, et al. (2010) Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 133(Pt 1):161–171.
15. Alexander-Bloch A, et al. (2012) The discovery of population differences in network community structure: New methods and applications to brain functional networks in schizophrenia. Neuroimage 59(4):3889–3900.
16. Kuncheva L, Hadjitodorov S (2004) Using diversity in cluster ensembles. IEEE International Conference on Systems, Man and Cybernetics 2:1214–1219.
17. Watts DJ, Strogatz SH (1998) Collective dynamics of ‘small-world’ networks. Nature 393(6684):440–442.
18. Latora V, Marchiori M (2001) Efficient behavior of small-world networks. Phys Rev Lett 87(19):198701.
19. Supekar K, Menon V, Rubin D, Musen M, Greicius MD (2008) Network analysis of intrinsic functional brain connectivity in Alzheimer’s disease. PLOS Comput Biol 4(6): e1000100.
20. Lynall ME, et al. (2010) Functional connectivity and brain networks in schizophrenia. J Neurosci 30(28):9477–9487.
21. Laureys S, Boly M, Maquet P (2006) Tracking the recovery of consciousness from coma. J Clin Invest 116(7):1823–1825.
22. Yao Z, et al.; Alzheimer’s Disease Neuroimaging Initiative (2010) Abnormal cortical networks in mild cognitive impairment and Alzheimer’s disease. PLOS Comput Biol 6 (11):e1001006.
23. Desmurget M, Bonnetblanc F, Duffau H (2007) Contrasting acute and slow-growing lesions: A new door to brain plasticity. Brain 130(Pt 4):898–914.
24. Tononi G, Sporns O, Edelman GM (1999) Measures of degeneracy and redundancy in biological networks. Proc Natl Acad Sci USA 96(6):3257–3262.
25. Doyle JC, Csete M (2011) Architecture, constraints, and behavior. Proc Natl Acad Sci USA 108(Suppl 3):15624–15630.
26. Bullmore E, Sporns O (2012) The economy of brain network organization. Nat Rev Neurosci 13(5):336–349.
27. Chen R, Cohen LG, Hallett M (2002) Nervous system reorganization following injury. Neuroscience 111(4):761–773.
28. Ward NS (2004) Functional reorganization of the cerebral motor system after stroke. Curr Opin Neurol 17(6):725–730.
29. Hagmann P, et al. (2010) White matter maturation reshapes structural connectivity in the late developing human brain. Proc Natl Acad Sci USA 107(44):19067–19072.
30. Honey CJ, Kötter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci USA 104(24):10240–10245.
31. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59(3):2142–2154.
32. Shiel A, et al. (2000) The Wessex Head Injury Matrix (WHIM) main scale: A preliminary report on a scale to assess and monitor patient recovery after severe head injury. Clin Rehabil 14(4):408–416.
33. Van Dijk KR, et al. (2010) Intrinsic functional connectivity as a tool for human con-nectomics: theory, properties, and optimization. J Neurophysiol 103(1):297–321.
34. Holmes CJ, et al. (1998) Enhancement of MR images using registration for signal averaging. J Comput Assist Tomogr 22(2):324–333.
35. Ashburner J (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38(1):95–113.
36. Tzourio-Mazoyer N, et al. (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15(1):273–289.
37. Fornito A, Zalesky A, Bullmore ET (2010) Network scaling effects in graph analytic studies of human resting-state FMRI data. Front Syst Neurosci 4:22.
38. Rubinov M, Sporns O (2010) Complex network measures of brain connectivity: Uses and interpretations. Neuroimage 52(3):1059–1069.
39. Van Essen DC, et al. (2001) An integrated software suite for surface-based analyses of cerebral cortex. J Am Med Inform Assoc 8(5):443–459.