Maternal and neonatal circulating markers ofmetabolic and cardiovascular risk in themetformin in gestational diabetes (mig) trial

Diabetes Care

Volumn 36, Issue 3, 2013, Pages 529-536

  Barrett, Helen L ^a   Gatford, Kathryn L ^a,b   Houda, Candice M ^c   De Blasio, Miles J ^d   Mcintyre, H David ^d   Callaway, Leonie K ^a   Nitert, Marloes Dekker ^a   Coat, Suzette ^a   Owens, Julie A ^e   Hague, William M ^f   Rowan, Janet A ^f  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^f AUCKLAND CITY HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BIRTH WEIGHT; BODY COMPOSITION; BODY MASS; CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MATERNAL BLOOD; MULTICENTER STUDY; NEWBORN; PREGNANCY DIABETES MELLITUS; PUERPERIUM; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; UMBILICAL CORD BLOOD;

ADULT; BLOOD GLUCOSE; C-PEPTIDE; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; DIABETES, GESTATIONAL; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INFANT, NEWBORN; INSULIN; LEPTIN; METFORMIN; PREGNANCY; RISK FACTORS; TRIGLYCERIDES;

EID: 84874426198     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-1097     Document Type: Article

References (40)

1. Hadar E, Hod M. Establishing consensus criteria for the diagnosis of diabetes in pregnancy following the HAPO study. Ann N Y Acad Sci 2010;1205:88-93
2. Metzger BE, Lowe LP, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358: 1991-2002
3. Carolan M, Davey MA, Biro MA, Kealy M. Maternal age, ethnicity and gestational diabetes mellitus. Midwifery 2012;28: 778-783
4. Reece EA. The fetal and maternal consequences of gestational diabetes mellitus. J Matern Fetal Neonatal Med 2010;23: 199-203
5. Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 2009;373: 1773-1779
6. Sullivan SD, Umans JG, Ratner R. Gestational diabetes: implications for cardiovascular health. Curr Diab Rep 2012;12: 43-52
7. Malcolm J. Through the looking glass: gestational diabetes as a predictor of maternal and offspring long-term health. Diabetes Metab Res Rev 2012;28:307-311
8. Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS; Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS) Trial Group. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005;352:2477-2486
9. Giugliano D, Quatraro A, Consoli G, et al. Metformin for obese, insulin-treated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors. Eur J Clin Pharmacol 1993;44: 107-112
10. Wulffelé MG, Kooy A, de Zeeuw D, Stehouwer CD, Gansevoort RT. The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review. J Intern Med 2004;256:1-14
11. Kirpichnikov D, McFarlane SI, Sowers Jr. Metformin: an update. Ann Intern Med 2002;137:25-33
12. Balani J, Hyer SL, Rodin DA, Shehata H. Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. Diabet Med 2009;26:798-802
13. Rowan JA,HagueWM, Gao W, BattinMR, Moore MP; MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008; 358:2003-2015
14. Nanovskaya TN, Nekhayeva IA, Patrikeeva SL, Hankins GD, Ahmed MS. Transfer of metformin across the dually perfused human placental lobule. Am J Obstet Gynecol 2006;195:1081-1085
15. Rowan JA, Rush EC, Obolonkin V, Battin M, Wouldes T, Hague WM. Metformin in gestational diabetes: the offspring followup (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34: 2279-2284
16. Larsson A, Palm M, Hansson LO, Axelsson O. Reference values for clinical chemistry tests during normal pregnancy. BJOG 2008;115:874-881
17. Schaefer-Graf UM, Meitzner K, Ortega-Senovilla H, et al. Differences in the implications of maternal lipids on fetal metabolism and growth between gestational diabetes mellitus and control pregnancies. Diabet Med 2011;28:1053-1059
18. Couch SC, Philipson EH, Bendel RB, Pujda LM, Milvae RA, Lammi-Keefe CJ. Elevated lipoprotein lipids and gestational hormones in women with diet-treated gestational diabetes mellitus compared to healthy pregnant controls. J Diabetes Complications 1998;12:1-9
19. Dimitriadis G, Mitrou P, Lambadiari V, Maratou E, Raptis SA. Insulin effects in muscle and adipose tissue. Diabetes Res Clin Pract 2011;93(Suppl. 1):S52-S59
20. Schaefer-Graf UM, Graf K, Kulbacka I, et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care 2008;31:1858-1863
21. Merzouk H, Bouchenak M, Loukidi B, Madani S, Prost J, Belleville J. Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition. J Clin Pathol 2000;53:917-923
22. Merzouk H, Meghelli-Bouchenak M, Loukidi B, Prost J, Belleville J. Impaired serum lipids and lipoproteins in fetal macrosomia related to maternal obesity. Biol Neonate 2000;77:17-24
23. Herrera E, Amusquivar E, López-Soldado I, Ortega H. Maternal lipid metabolism and placental lipid transfer. Horm Res 2006;65(Suppl. 3):59-64
24. Lindegaard ML, Damm P, Mathiesen ER, Nielsen LB. Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression. J Lipid Res 2006;47:2581-2588
25. Gauster M, Hiden U, van Poppel M, et al. Dysregulation of placental endothelial lipase in obese women with gestational diabetes mellitus. Diabetes 2011;60: 2457-2464
26. Ogonowski J, Miazgowski T, Czeszy-nska MB, Jaskot B, Kuczy-nska M, Celewicz Z. Factors influencing risk of macrosomia in women with gestational diabetes mellitus undergoing intensive diabetic care. Diabetes Res Clin Pract 2008;80:405-410
27. Lowe LP, Metzger BE, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations of maternal A1C and glucose with pregnancy outcomes. Diabetes Care 2012;35:574-580
28. Valensise H, Larciprete G, Vasapollo B, et al. C-peptide and insulin levels at 24-30 weeks' gestation: an increased risk of adverse pregnancy outcomes? Eur J Obstet Gynecol Reprod Biol 2002;103:130-135
29. Di Cianni G, Miccoli R, Volpe L, et al. Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance. Diabet Med 2005;22: 21-25
30. Kitajima M, Oka S, Yasuhi I, Fukuda M, Rii Y, Ishimaru T. Maternal serum triglyceride at 24-32 weeks' gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstet Gynecol 2001;97:776-780
31. Son GH, Kwon JY, Kim YH, Park YW. Maternal serum triglycerides as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus. Acta Obstet Gynecol Scand 2010;89:700-704
32. Clausen T, Burski TK, Øyen N, Godang K, Bollerslev J, Henriksen T. Maternal anthropometric and metabolic factors in the first half of pregnancy and risk of neonatal macrosomia in term pregnancies. A prospective study. Eur J Endocrinol 2005; 153:887-894
33. Misra VK, Trudeau S, Perni U. Maternal serum lipids during pregnancy and infant birth weight: the influence of prepregnancy BMI. Obesity (Silver Spring) 2011; 19:1476-1481
34. Siri-Tarino PW. Effects of diet on highdensity lipoprotein cholesterol. Curr Atheroscler Rep 2011;13:453-460
35. Marchetti P, Benzi L, Cerri M, et al. Effect of plasma metformin concentrations on serum lipid levels in type II diabetic patients. Acta Diabetol Lat 1988;25:55-62
36. Matsuki K, Tamasawa N, Yamashita M, et al. Metformin restores impaired HDLmediated cholesterol efflux due to glycation. Atherosclerosis 2009;206:434-438
37. Chakraborty A,Chowdhury S, Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract 2011;93:56-62
38. Geary M, Pringle PJ, Persaud M, et al. Leptin concentrations in maternal serum and cord blood: relationship to maternal anthropometry and fetal growth. Br J Obstet Gynaecol 1999;106:1054-1060
39. Ramos GA, Hanley AA, Aguayo J,Warshak CR, Kim JH, Moore TR. Neonatal chemical hypoglycemia in newborns from pregnancies complicated by type 2 and gestational diabetes mellitus-The importance of neonatal ponderal index. J Matern Fetal Neonatal Med 2012;25:267-271
40. Pedersen J. Diabetes and Pregnancy: Blood Sugar of Newborn Infants. Copenhagen, Denmark, Danish Science Press, 1952