Effect of donor age and cold storage time on outcome in recipients of kidneys donated after circulatory death in the UK: A cohort study

The Lancet

Volumn 381, Issue 9868, 2013, Pages 727-734

  Summers, Dominic M ^a,b,c   Johnson, Rachel J ^c   Hudson, Alex ^c   Collett, David ^c   Watson, Christopher J ^a,b   Bradley, J Andrew ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b and University of Bristol   (United Kingdom)

^c NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; ARTICLE; BRAIN DEATH; COHORT ANALYSIS; COLD ISCHEMIA; COMPARATIVE STUDY; CRYOPRESERVATION; DONOR AGE; FEMALE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; KIDNEY; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; UNITED KINGDOM;

EID: 84874402593     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)61685-7     Document Type: Article

References (21)

1. NHSBT. Transplant ativity in the UK-activity report 2010-11. http://www.organdonation.nhs.uk/ukt/statistics/transplant- activity-report/ archive-activity-reports/pdf/ukt/activity- report-2010-11.pdf (accessed June 18, 2012).
2. Klein A, Messersmith E, Ratner L, Kochik R, Baliga P, Ojo A. Organ donation and utilization in the United States, 1999-2008. Am J Transplant 2010; 10: 973-86.
3. Kootstra G, Daemen J, Oomen A. Categories of non-heart-beating donors. Transplant Proc 1995; 27: 2893-94.
4. Locke J, Segev D, Warren D, Dominici F, Simpkins C, Montgomery R. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation. Am J Transplant 2007; 7: 1797-807.
5. Snoeijs MGJ, Winkens B, Heemskerk MBA, et al. Kidney transplantation from donors after cardiac death: a 25-year experience. Transplantation 2010; 90: 1106-12.
6. Summers DM, Johnson RJ, Allen J, et al. Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study. Lancet 2010; 376: 1303-11.
7. Rao PS, Ojo A. The alphabet soup of kidney transplantation: SCD, DCD, ECD-fundamentals for the practicing nephrologist. Clin J Am Soc Nephrol 2009; 4: 1827-31.
8. Johnson R, Fuggle S, Mumford L, Bradley J, Forsythe J, Rudge C. A new UK 2006 National Kidney Allocation Scheme for deceased heart-beating donor kidneys. Transplantation 2010; 89: 387-94.
9. Johnson R, Fuggle S, O'Neill J, et al. Factors influencing outcome after deceased heart beating donor kidney transplantation in the United Kingdom: an evidence base for a new national kidney allocation policy. Transplantation 2010; 89: 379-86.
10. Kayler LK, Srinivas TR, Schold JD. Influence of CIT-induced DGF on kidney transplant outcomes. Am J Transplant 2011; 11: 2657-64.
11. Gómez MP, Arredondo E, Páez G, Manyalich M. International registry in organ donation and transplantation 2010. Transplant Proc 2012; 44: 1592-97.
12. de Fijter J W, Mallat MJ, Doxiadis II, et al. Increased immunogenicity and cause of graft loss of old donor kidneys. J Am Soc Nephrol 2001; 12: 1538-46.
13. van der Vliet JA, Warle MC, Cheung CL, Teerenstra S, Hoitsma AJ. Influence of prolonged cold ischemia in renal transplantation. Clin Transplant 2011; 25: E612-16.
14. Rao P, Schaubel D, Guidinger M, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation 2009; 88: 231-36.
15. Watson CJ, Johnson RJ, Birch R, Collett D, Bradley JA. A simplified donor risk index for predicting outcome after deceased donor kidney transplantation. Transplantation 2012; 93: 314-18.
16. Moreso F, Serón D, Gil-Vernet S, et al. Donor age and delayed graft function as predictors of renal allograft survival in rejection-free patients. Nephrol Dial Transplant 1999; 14: 930-35.
17. Kayler LK, Magliocca J, Zendejas I, Srinivas TR, Schold JD. Impact of cold ischemia time on graft survival among ECD transplant recipients: a paired kidney analysis. Am J Transplant 2011; 11: 2647-56.
18. Opelz G, Döhler B. Multicenter analysis of kidney preservation. Transplantation 2007; 83: 247-53.
19. NHSBT. Median waiting time to kidney transplant. http://www. organdonation.nhs.uk/ukt/statistics/centre-specific-reports/pdf/ waiting-time-to-transplant.pdf (accessed June 18, 2012).
20. Watson CJ, Wells AC, Roberts RJ, et al. Cold machine perfusion versus static cold storage of kidneys donated after cardiac death: a UK multicenter randomized controlled trial. Am J Transplant 2010; 10: 1991-99.
21. Jochmans I, Moers C, Smits JM, et al. Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: a multicenter, randomized, controlled trial. Ann Surg 2010; 252: 756-64.