Comparison of flow-through cell and paddle methods for testing vaginal tablets containing a poorly water-soluble drug

Tropical Journal of Pharmaceutical Research

Volumn 12, Issue 1, 2013, Pages 39-44

  Szymanska, Emilia ^a   Winnicka, Katarzyna ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Clotrimazole; Dissolution test; Flow through cell method; Paddle method

Indexed keywords

CLOTRIMAZOLE;

AGITATION; ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; DRUG RELEASE; DRUG SOLUBILITY; FLOW RATE; FLOW THROUGH CELL METHOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PADDLE METHOD; PH; TABLET DISINTEGRATION TIME; TABLET FORMULATION;

EID: 84874359601     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v12i1.7     Document Type: Article

References (17)

1. Azarmi S, Roa W, Löbenberg R. Current perspectives in dissolution testing of conventional and novel dosage forms. Int J Pharm. 2007; 2: 12-21.
2. European Pharmacopeia. Directorate for the quality of Medicines & Healthcare of the Council of Europe, Strasburg, 6th edition, 2007; Vol. 1: pp.266-275.
3. Emami J. In vitro-in vivo correlation: from theory to applications. J Pharm Pharmaceut Sci. 2006; 9: 169-189.
4. Shiko G, Gladden LF, Sederman AJ, Connolly PC, Butler JM. MRI studies of the hydrodynamics in a USP 4 dissolution testing cell. J Pharm Sci. 2011; 100: 976-991.
5. Baxter JL, Kukura J, Muzzio FJ. Shear-induced variability in the United States pharmacopeia apparatus 2: modification to the existing system. AAPS J. 2006; 7: E857-E864.
6. Langenbucher F, Benz D Kurth W Moller H, Otz M. Standardized flow-cell method as an alternative to existing pharmacopeial dissolution testing. Pharm Ind 1989; 51: 1276-1281.
7. The United States Pharmacopeia. The United States Pharmacopeial Convention, Baltimore, 32th edn, 2009; Vol 1: pp 263-272.
8. Singh I, Aboul-Enein HY. Advantages of USP Apparatus IV (Flow-through cell apparatus) in dissolution studies. J Iran Chem Soc 2006; 3: 220-222.
9. Bhardwaj U, Burgess DJ. A novel UP apparatus 4 based release testing method for dispersed systems. Int J Pharm 2010; 388: 287-294.
10. Zhang GH, Vadino WA, Yang TT, Cho WP, Chaudry IA. Evaluation of the flow through cell dissolution apparatus: effects of flow rate, glass beads and tablet position on drug release from different types of tablets. Drug Dev Ind Pharm 1994; 20: 2063-2078.
11. Hu J, Kyad A, Ku V, Zhou P, Cauchon N. A comparison of dissolution testing on lipid soft gelatin capsules using USP apparatus 2 and apparatus 4. Dissol Tech. 2005; 12: 6-9.
12. Zolnik B, Raton J-L, Burgess D. Application of USP apparatus 4 and in situ fiberoptic analysis to microsphere release testing. Dissol Tech. 2005; 12: 11-14.
13. FDA-Recommended Dissolution Methods [homepage on the Internet]. U.S. Food and Drug Administration, U.S. Department of Health & Human Services; [cited 2011 Dec 21]. Available from: http.//www.accessdata.fda.gov
14. Hájková R, Sklenářová H, Matysová L, Švecová P, Solich P. Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulations. Talanta 2007; 73: 483-489.
15. Hashiguchi T, Kodama A, Ryu A, Otagiri M. Retention capacity of topical imidazole antifungal agents in the skin. Int J. Pharm. 1998; 161: 195-204.
16. Bachhav YG, Patravale VB. Microemulsion-based vaginal gel of clotrimazole: formulation, in vitro evaluation, and stability studies. AAPS PharmSciTech. 2009; 10: 476-481.
17. Brown W. Apparatus 4 flow through cell: some thoughts on operational characteristics. Dissol Tech. 2005; 5: 28-30.