Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: A single institution study of 59 patients

Korean Journal of Pediatrics

Volumn 56, Issue 1, 2013, Pages 26-31

  Kim, Hyun O ^a   Oh, Hun Jin ^a   Lee, Jae Wook ^a   Jang, Pil Sang ^a   Chung, Nack Gyun ^a   Cho, Bin ^a   Kim, Hack Ki ^a  

^a The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

Child; Hematopoietic stem cell transplantation; Immune reconstitution inflammatory syndrome; Lymphocyte subset

Indexed keywords

ACICLOVIR; CD16 ANTIGEN; CD19 ANTIGEN; CD56 ANTIGEN; COTRIMOXAZOLE; CYCLOSPORIN; FLUCONAZOLE; GRANULOCYTE COLONY STIMULATING FACTOR; METHOTREXATE; MICAFUNGIN; RITUXIMAB;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; B LYMPHOCYTE; BONE MARROW EXAMINATION; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; COHORT ANALYSIS; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS INFECTION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; FOLLOW UP; GRAFT VERSUS HOST REACTION; HELPER CELL; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOPHENOTYPING; INFANT; INFECTION; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER T CELL; NEUTROPHIL COUNT; NEWBORN; PERIPHERAL LYMPHOCYTE; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84874354928     PISSN: 17381061     EISSN: 20927258     Source Type: Journal    
DOI: 10.3345/kjp.2013.56.1.26     Document Type: Article

References (17)

1. Williams KM, Gress RE. Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation. Best Pract Res Clin Haematol 2008;21:579-596.
2. Hannet I, Erkeller-Yuksel F, Lydyard P, Deneys V, DeBruyere M. Develop mental and maturational changes in human blood lymphocyte sub populations. Immunol Today 1992;13:215, 218.
3. Bae KW, Kim BE, Koh KN, Im HJ, Seo JJ. Factors influencing lymphocyte reconstitution after allogeneic hematopoietic stem cell transplantation in children. Korean J Hematol 2012;47:4452.
4. Kalwak K, Gorczynska E, Toporski J, Turkiewicz D, Slociak M, Ussowicz M, et al. Immune reconstitution after haematopoietic cell transplantation in children: immunophenotype analysis with regard to factors affecting the speed of recovery. Br J Haematol 2002;118:74-89.
5. de Vries E, van Tol MJ, van den Bergh RL, Waaijer JL, ten Dam MM, Hermans J, et al. Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation. Bone Marrow Transplant 2000;25:267-275.
6. Small TN, Papadopoulos EB, Boulad F, Black P, Castro-Malaspina H, Childs BH, et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood 1999;93:467-480.
7. Heining C, Spyridonidis A, Bernhardt E, Schulte-Monting J, Behringer D, Grullich C, et al. Lymphocyte reconstitution following allogeneic hematopoietic stem cell transplantation: a retrospective study in cluding 148 patients. Bone Marrow Transplant 2007;39:613-622.
8. Lynch BA, Vasef MA, Comito M, Gilman AL, Lee N, Ritchie J, et al. Effect of in vivo lymphocyte-depleting strategies on development of lym phoproliferative disorders in children post allogeneic bone marrow transplantation. Bone Marrow Transplant 2003;32:527-533.
9. Jimenez M, Martinez C, Ercilla G, Carreras E, Urbano-Ispizua A, Ayme rich M, et al. Reduced-intensity conditioning regimen preserves thy mic function in the early period after hematopoietic stem cell trans plantation. Exp Hematol 2005;33:1240-1248.
10. Kuzushima K, Kimura H, Hoshino Y, Yoshimi A, Tsuge I, Horibe K, et al. Longitudinal dynamics of Epstein-Barr virusspecific cytotoxic T lym phocytes during post-transplant lymphoproliferative disorder. J Infect Dis 2000;182:937-940.
11. Gartner BC, Schafer H, Marggraff K, Eisele G, Schafer M, Dilloo D, et al. Evaluation of use of Epstein-Barr viral load in patients after allogeneic stem cell transplantation to diagnose and monitor post-transplant lymphoproliferative disease. J Clin Microbiol 2002;40:351-358.
12. Stevens SJ, Verschuuren EA, Pronk I, van Der Bij W, Harmsen MC, The TH, et al. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of post-transplant lymphoproliferative disease in highrisk patients. Blood 2001;97:1165-1171.
13. Izumiya S, Ishida M, Hodohara K, Yoshida T, Okabe H. EpsteinBarr virus-associated lymphoproliferative disorder developed following auto logous peripheral blood stem cell transplantation for relapsing Hodgkin's lymphoma. Oncol Lett 2012;3:1203-1206.
14. Olkinuora H, von Willebrand E, Kantele JM, Vainio O, Talvensaari K, Saarinen-Pihkala U, et al. The impact of early viral infections and graft-versus-host disease on immune reconstitution following paediatric stem cell transplantation. Scand J Immunol 2011; 73:586-593.
15. Wingate PJ, McAulay KA, Anthony IC, Crawford DH. Regulatory T cell activity in primary and persistent Epstein-Barr virus infection. J Med Virol 2009;81:870-877.
16. Pagliara D, Savoldo B. Cytotoxic T lymphocytes for the treatment of viral infections and post-transplant lymphoproliferative disorders in transplant recipients. Curr Opin Infect Dis 2012;25: 431-437.
17. + T-cell deficiency, Epstein-Barr virus infection, vitamin D deficiency, and steps to autoimmunity: a unifying hypothesis. Auto immune Dis 2012;2012:189096.