Neurotoxicological evaluation of microcystin-LR exposure at environmental relevant concentrations on nematode Caenorhabditis elegans

Environmental Science and Pollution Research

Volumn 20, Issue 3, 2013, Pages 1823-1830

  Ju, Jingjuan ^a   Ruan, Qinli ^a   Li, Xiaobo ^a   Liu, Ran ^a   Li, Yunhui ^a   Pu, Yuepu ^a   Yin, Lihong ^a   Wang, Dayong ^b  

^a SOUTHEAST UNIVERSITY   (China)

^b MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

C. elegans; Environmental relevant concentration; GABAergic neuron; Microcystin LR; Neuronal loss; Neurotoxicity

Indexed keywords

CONCENTRATION (COMPOSITION); FREQUENCY ANALYSIS; GENE EXPRESSION; NEMATODE; NEUROLOGY; PEPTIDE; POLLUTION EFFECT; POLLUTION EXPOSURE; TOXICOLOGY; TOXIN;

CAENORHABDITIS ELEGANS; NEMATODA;

EID: 84874296251     PISSN: 09441344     EISSN: 16147499     Source Type: Journal    
DOI: 10.1007/s11356-012-1151-2     Document Type: Article

References (44)

1. Anderson GL, Boyd WA, Williams PL (2001) Assessment of sublethal endpoints for toxicity testing with the nematode Caenorhabditis elegans. Environ Toxicol Chem 20: 833-838.
2. Anderson GL, Cole RD, Williams PL (2004) Assessing behavioral toxicity with Caenorhabditis elegans. Environ Toxicol Chem 23: 1235-1240.
3. Baganz D, Staaks G, Steinberg C (1998) Impact of the cyanobacteria toxin, microcystin-LR on behaviour of zebrafish, Danio rerio. Water Res 32: 948-952.
4. Baganz D, Staaks G, Pflugmacher S, Steinberg CEW (2004) Comparative study of microcystin-LR-induced behavioral changes of two fish species, Danio rerio and Leucaspius delineatus. Environ Toxicol 19: 564-570.
5. Boyd WA, Williams PL (2003) Availability of metals to the nematode Caenorhabditis elegans: toxicity based on total concentrations in soil and extracted fractions. Environ Toxicol Chem 22: 1100-1106.
6. Brenner S (1974) The genetics of Caenorhbditis elegans. Genetics 77: 71-94.
7. Brockie PJ, Maricq AV (2006) Ionotropic glutamate receptors: genetics, behavior and electrophysiology. WormBook. doi: 10. 1895/wormbook. 1. 61. 1.
8. Cazenave J, Nores ML, Miceli M, Díaz MP, Wunderlin DA, Bistoni MA et al (2008) Changes in the swimming activity and the glutathione S-transferase activity of Jenynsia multidentata fed with microcystin-RR. Water Res 42: 1299-1307.
9. Du M, Wang DY (2009) The neurotoxic effects of heavy metal exposure on GABAergic nervous system in nematode Caenorhabditis elegans. Environ Toxicol Pharmacol 27: 314-320.
10. Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B (2005) Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicol Appl Pharmacol 203: 257-263.
11. Gélinas M, Juneau P, Gagné F (2012) Early biochemical effects of Microcystis aeruginosa extracts on juvenile rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol B Biochem Mol Biol 161: 261-267.
12. Helmcke KJ, Syversen T, Miller DM, Aschner M (2009) Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol 240: 265-272.
13. Hitzfeld B, Hoger S, Dietrich D (2000) Cyanobacterial toxins: removal during drinking water treatment, and human risk assessment. Environ Health Perspect 108: 113-122.
14. Jasionek G, Zhdanov A, Davenport J, Blaha L, Papkovsky DB (2010) Mitochondrial toxicity of microcystin-LR on cultured cells: application to the analysis of contaminated water samples. Environ Sci Technol 44: 2535-2541.
15. Jiang GCT, Tidwell K, McLaughlin BA, Cai J, Gupta RC, Milatovic D et al (2007) Neurotoxic potential of depleted uranium-effects in primary cortical neuron cultures and in Caenorhabditis elegans. Toxicol Sci 99: 553-565.
16. Jochimsen EM, Carmichael WW, An JS, Cardo DM, Cookson ST, Holmes CEM et al (1998) Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. New Engl J Med 338: 873-878.
17. Jorgensen EM (2005) GABA. WormBook. doi: 10. 1895/wormbook. 1. 14. 1.
18. Kist LW, Rosemberg DB, Pereira TCB, de Azevedo MB, Richetti SK, de Castro LJ et al (2012) Microcystin-LR acute exposure increases AChE activity via transcriptional ache activation in zebrafish (Danio rerio) brain. Comp Biochem Physiol C Toxicol Pharmacol 155: 247-252.
19. Kraemer BC, Burgess JK, Chen JH, Thomas JH, Schellenberg GD (2006) Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Hum Mol Genet 15: 1483-1496.
20. Leung MC, Williams PL, Benedetto A, Au C, Helmcke KJ, Aschner M et al (2008) Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci 106: 5-28.
21. Li YH, Wang Y, Yin LH, Pu YP, Wang DY (2009a) Using the nematode Caenorhabditis elegans as a model animal for assessing the toxicity induced by microcystin-LR. J Environ Sci 21: 395-401.
22. Li YH, Ye HY, Du M, Zhang YF, Ye BP, Pu YP et al (2009b) Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR exposure in nematode Caenorhabditis elegans. J Environ Sci 21: 971-979.
23. MacKintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett 264: 187-192.
24. Maidana M, Carlis V, Galhardi FG, Yunes JS, Geracitano LA, Monserrat JM et al (2006) Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats. Chem Biol Interact 159: 223-234.
25. Mutwakil MHAZ, Reader JP, Holdich DM, Smithurst PR, Candido EPM, Jones D et al (1997) Use of stress-inducible transgenic nematodes as biomarkers of heavy metal pollution in water samples from an English river system. Arch Environ Contam Toxicol 32: 146-153.
26. Pavagadhi S, Gong ZY, Handed MP, Dionysioue DD, de la Cruzf AA, Balasubramanianb R (2012) Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: a balneation study. Aquat Toxicol 109: 1-10.
27. Pereira VM, Bortolotto JW, Kist LW, de Azevedo MB, Fritsch RS, da Luz OR et al (2012) Endosulfan exposure inhibits brain AChE activity and impairs swimming performance in adult zebrafish (Danio rerio). Neurotoxicology 33: 469-475.
28. Pouria S, de Andrade A, Barbosa J, Cavalcanti RL, Barreto VTS, Ward CJ et al (1998) Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 352: 21-26.
29. Rand JB (2007) Acetylcholine. WormBook. doi: 10. 1895/wormbook. 1. 131. 1.
30. Roh JY, Choi J (2008) Ecotoxicological evaluation of chlorpyrifos exposure on the nematode Caenorhabditis elegans. Ecotoxicol Environ Saf 71: 483-489.
31. Roh JY, Jung IH, Lee JY, Choi J (2007) Toxic effects of di(2-ethylhexyl)phthalate on mortality, growth, reproduction and stress-related gene expression in the soil nematode Caenorhabditis elegans. Toxicol 237: 126-133.
32. Ruan QL, Ju JJ, Li YH, Liu R, Pu YP, Yin LH et al (2009) Evaluation of pesticide toxicities with differing mechanisms using Caenorhabditis elegans. J Toxicol Environ Health A 72: 746-751.
33. Runnegar M, Berndt N, Kaplowitz N (1995) Microcystin uptake and inhibition of protein phosphatases effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol 134: 264-272.
34. Schuske K, Beg AA, Jorgensen EM (2004) The GABA nervous system in C. elegans. Trends Neurosci 27: 407-414.
35. Wand Q, Xie P, Chen J, Liang GD (2008) Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection. Toxicon 52: 721-727.
36. Wang DY, Wang Y (2008) Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny. Environ Pollut 151: 585-592.
37. Wang DY, Xing XJ (2008) Assessment of locomotion behavioral defects induced by acute toxicity from heavy metal exposure in nematode Caenorhabditis elegans. J Environ Sci 20: 1132-1137.
38. Wang DY, Shen LL, Wang Y (2007) The phenotypic and behavioral defects can be transferred from zinc exposed nematodes to their progeny. Environ Toxicol Pharmacol 24: 223-230.
39. White J, Southgate E, Thomson JN, Brenner S (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc London Ser B 314: 1-340.
40. Xing XJ, Guo YL, Wang DY (2009) Using the larvae nematode Caenorhabditis elegans to evaluate neurobehavioral toxicity to metallic salts. Ecotoxicol Environ Saf 72: 1819-1823.
41. Xu QJ, Chen WM, Gao GG (2008) Seasonal variations in microcystin concentrations in Lake Taihu, China. Environ Monit Assess 145: 75-79.
42. Yang H, Xie P, Xu L, Zheng L, Deng D, Zhou Q et al (2006) Seasonal variation of microcystin concentration in Lake Chaohu, a shallow subtropical lake in the People's Republic of China. Bull Environ Contam Toxicol 77: 367-374.
43. Ye WJ, Liu XL, Tan J, Li DT, Yang H (2009) Diversity and dynamics of microcystin-producing cyanobacteria in China's third largest lake, Lake Taihu. Harmful Algae 8: 637-644.
44. Zitova A, Jasionek G, Papkovsky DB (2011) Water toxicity monitoring using optical oxygen sensing and respirometry. Waste Water Eval Manag. doi: 10. 5772/21129.