Studies of inositol 1-phosphate analogues as inhibitors of the phosphatidylinositol phosphate synthase in mycobacteria

Journal of Biochemistry

Volumn 153, Issue 3, 2013, Pages 257-266

  Morii, Hiroyuki ^a   Okauchi, Tatsuo ^b   Nomiya, Hiroki ^b   Ogawa, Midori ^a   Fukuda, Kazumasa ^a   Taniguchi, Hatsumi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

enzyme inhibitors; inositol; mycobacteria; phospholipid biosynthesis; tuberculosis

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATE SYNTHASE; PHOSPHATIDYLINOSITOL PHOSPHATE SYNTHASE ANALOGUE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; KINETICS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

BACTERIAL PROTEINS; BIOCATALYSIS; BIOSYNTHETIC PATHWAYS; CDP-DIACYLGLYCEROL-INOSITOL 3-PHOSPHATIDYLTRANSFERASE; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; INOSITOL PHOSPHATES; KINETICS; MAGNESIUM; MANGANESE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; SUBSTRATE SPECIFICITY;

EID: 84874293129     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvs141     Document Type: Article

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