Cognitive endophenotypes in a family with bipolar disorder with a risk locus on chromosome 4

Bipolar Disorders

Volumn 15, Issue 2, 2013, Pages 215-222

  Drysdale, Emma ^a,b   Knight, Helen M ^a   Mcintosh, Andrew M ^a   Blackwood, Douglas Hr ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bipolar disorder; Chromosome 4; Cognition; Depression; Genetic susceptibility; Haplotype

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CHROMOSOME 4; COGNITION; CONTROLLED STUDY; ENDOPHENOTYPE; EXECUTIVE FUNCTION; FAMILY HISTORY; GENE LOCUS; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; VERBAL MEMORY;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; CHROMOSOMES, HUMAN, PAIR 4; COGNITION DISORDERS; ENDOPHENOTYPES; FAMILY HEALTH; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; RISK; VERBAL LEARNING; YOUNG ADULT;

EID: 84874286146     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/bdi.12040     Document Type: Article

References (37)

1. Kieseppa T, Partonen T, Haukka J, Kaprio J, Lonnqvist J. High concordance of bipolar I disorder in a nationwide sample of twins. Am J Psychiatry 2004; 161: 1814-1821.
2. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Archiv Gen Psychiatry 2003; 60: 1187-1192.
3. Knight HM, Pickard BS, Maclean A et al.A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am J Hum Genet 2009; 85: 833-846.
4. Lichtenstein P, Yip BH, Bjork C et al.Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009; 373: 234-239.
5. Wray NR, Pergadia ML, Blackwood DH et al.Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 2012; 17: 36-48.
6. Robinson LJ, Thompson JM, Gallagher P et al.A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 2006; 93: 105-115.
7. Torralva T, Strejilevich S, Gleichgerrcht E et al.Deficits in tasks of executive functioning that mimic real-life scenarios in bipolar disorder. Bipolar Disord 2012; 14: 118-125.
8. Weiland-Fiedler P, Erickson K, Waldeck T et al.Evidence for continuing neuropsychological impairments in depression. J Affect Disord 2004; 82: 253-258.
9. Rasetti R, Weinberger DR. Intermediate phenotypes in psychiatric disorders. Curr Opin Genet Dev 2011; 21: 340-348.
10. Clark L, Sarna A, Goodwin GM. Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression. Am J Psychiatry 2005; 162: 1980-1982.
11. Schulze KK, Walshe M, Stahl D et al.Executive functioning in familial bipolar I disorder patients and their unaffected relatives. Bipolar Disord 2011; 13: 208-216.
12. Owens SF, Rijsdijk F, Picchioni MM et al.Genetic overlap between schizophrenia and selective components of executive function. Schizophr Res 2011; 127: 181-187.
13. St Clair D, Blackwood D, Muir W et al.Association within a family of a balanced autosomal translocation with major mental illness. Lancet 1990; 336: 13-16.
14. Venken T, Del-Favero J. Chasing genes for mood disorders and schizophrenia in genetically isolated populations. Hum Mutation 2007; 28: 1156-1170.
15. Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 2001; 69: 428-433.
16. Keating M, Atkinson D, Dunn C, Timothy K, Vincent GM, Leppert M. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science 1991; 252: 704-706.
17. Blackwood DH, He L, Morris SW et al.A locus for bipolar affective disorder on chromosome 4p. Nat Genet 1996; 12: 427-430.
18. Visscher PM, Yazdi MH, Jackson AD et al.Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families. Psychiatr Genet 2001; 11: 129-137.
19. Christoforou A, Le Hellard S, Thomson PA et al.Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. Mol Psychiatry 2007; 12: 1011-1025.
20. Le Hellard S, Lee AJ, Underwood S et al.Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder. Biol Psychiatry 2007; 61: 797-805.
21. Als TD, Dahl HA, Flint TJ et al.Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands. Mol Psychiatry 2004; 9: 93-98.
22. Asherson P, Mant R, Williams N et al.A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder. Mol Psychiatry 1998; 3: 310-320.
23. Detera-Wadleigh SD, Badner JA, Berrettini WH et al.A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96: 5604-5609.
24. Spitzer RI, Endicott J. Schedule for Affective Disorders and Schizophrenia, Biometrics Research Evaluation Section. New York: New York State Psychiatric Institute, 1978.
25. Nelson HE, Willison J. National Adult Reading Test, 2nd edn. Windsor: NFER-Nelson, 1991.
26. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
27. Blackburn IM, Loudon JB, Ashworth CM. A new scale for measuring mania. Psycholog Med 1977; 7: 453-458.
28. Delis DC, Kramer JH, Kaplan E, Ober BA. The California Verbal Learning Test-Adult Version Research Addition Manual Version 1. San Antonio: The Psychological Corporation, 1987.
29. Benton A, Hamsher KDS. Multilingual Aphasia Examination Manual- Revised. Iowa City: University of Iowa, 1978.
30. Burgess PW, Shallice T. Hayling and Brixton Tests Manual. Bury St Edmunds: Thames Valley Test Company, 1997.
31. Zanelli J, Reichenberg A, Morgan K et al.Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. Am J Psychiatry 2010; 167: 78-85.
32. Balanza-Martinez V, Rubio C, Selva-Vera G et al.Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: a systematic review. Neurosci Biobehav Rev 2008; 32: 1426-1438.
33. Arts B, Jabben N, Krabbendam L, van Os J. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psycholog Med 2008; 38: 771-785.
34. Chen RY, Chen EY, Chan CK, Lam LC, Lieh-Mak F. Verbal fluency in schizophrenia: reduction in semantic store. Austral N Z J Psychiatry 2000; 34: 43-48.
35. Hodges JR, Salmon DP, Butters N. Semantic memory impairment in Alzheimer's disease: failure of access or degraded knowledge?Neuropsychologia 1992; 30: 301-314.
36. Bousfield WA. The occurrence of clustering in the recall of randomly arranged associates. J Gen Psychology 1953; 49: 229-240.
37. Bousfield WA, Cohen BH. The occurrence of clustering in the recall of randomly arranged words of different frequencies of usage. J Gen Psychol 1955; 30: 149-165.