Combinatorial co-encapsulation of hydrophobic molecules in poly(lactide-co-glycolide) microparticles

Biomaterials

Volumn 34, Issue 13, 2013, Pages 3422-3430

  Acharya, Abhinav P ^a   Lewis, Jamal S ^a   Keselowsky, Benjamin G ^a  

^a University of Florida   (United States)

Author keywords

Co encapsulation; Combinatorial; Fabrication; High throughput; Microparticle; Microsphere

Indexed keywords

A-PARTICLES; BIOLOGICAL MOLECULE; CO-ENCAPSULATION; COMBINATORIAL; CONTROLLED RELEASE; FLUORESCENT DYES; HIGH-THROUGHPUT; HYDROPHOBIC MOLECULES; IMAGING MODALITY; LOADING CONCENTRATION; LOW COSTS; MICRO PARTICLES; MULTI WELLS; MULTIPLE FACTORS; NEW COMPONENTS; OIL-IN-WATER EMULSIONS; PARTICLE FORMULATION; PARTICLE PRODUCTION; PERSONALIZED MEDICINES; PLGA PARTICLES; POLY-LACTIDE-CO-GLYCOLIDE; SMALL POPULATION; SMALL-MOLECULE DRUGS; TARGETED DELIVERY;

ACTIVATION ANALYSIS; EMULSIONS; FABRICATION; HYDROPHOBICITY; INTERNET PROTOCOLS; MICROSPHERES; MOLECULES; POLYSTYRENES;

COPOLYMERS;

FLUORESCENT DYE; POLYGLACTIN; POLYSTYRENE; WATER OIL CREAM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; COMBINATORIAL LIBRARY; CONTROLLED STUDY; COST; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; IMAGING; MICROENCAPSULATION; MICROTECHNOLOGY; MOUSE; NONHUMAN; PERSONALIZED MEDICINE; PRIORITY JOURNAL;

ANIMALS; DENDRITIC CELLS; DRUG COMPOUNDING; FLUORESCENT DYES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTIC ACID; MICE; MICE, INBRED C57BL; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID;

EID: 84874276787     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.032     Document Type: Article

References (26)

1. Hamdy S., Haddadi A., Hung R.W., Lavasanifar A. Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations. Drug Deliv Rev 2011, 63:943-955.
2. Singh A., Nie H., Ghosn B., Qin H., Kwak L.W., Roy K. Efficient modulation of T-cell response by dual-mode, single-carrier delivery of cytokine-targeted siRNA and DNA vaccine to antigen-presenting cells. Mol Ther 2008, 16:2011-2021.
3. Diwan M., Tafaghodi M., Samuel J. Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres. J Control Release 2002, 85:247-262.
4. Figueiredo M., Esenaliev R. PLGA Nanoparticles for ultrasound-mediated gene delivery to solid tumors. J Drug Deliv 2012, 2012:767839.
5. Keselowsky B.G., Xia C.Q., Clare-Salzler M. Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes. Hum Vaccin 2011, 7:37-44.
6. Jain R.A. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000, 21:2475-2490.
7. Norton L.W., Park J., Babensee J.E. Biomaterial adjuvant effect is attenuated by anti-inflammatory drug delivery or material selection. J Control Release 2010, 146:341-348.
8. Lewis J.S., Zaveri T.D., Crooks C.P., Keselowsky B.G. Microparticle surface modifications targeting dendritic cells for non-activating applications. Biomaterials 2012, 33:7221-7232.
9. Choe S.W., Acharya A.P., Keselowsky B.G., Sorg B.S. Intravital microscopy imaging of macrophage localization to immunogenic particles and co-localized tissue oxygen saturation. Acta Biomater 2010, 6:3491-3498.
10. Acharya A.P., Clare-Salzler M.J., Keselowsky B.G. A high-throughput microparticle microarray platform for dendritic cell-targeting vaccines. Biomaterials 2009, 30:4168-4177.
11. Husmann M., Schenderlein S., Lück M., Lindner H., Kleinebudde P. Polymer erosion in PLGA microparticles produced by phase separation method. Int J Pharm 2002, 242:277-280.
12. Aubert-Pouëssel A., Venier-Julienne M.C., Saulnier P., Sergent M., Benoît J.P. Preparation of PLGA microparticles by an emulsion-extraction process using glycofurol as polymer solvent. Pharm Res 2004, 21:2384-2391.
13. Acharya A.P., Dolgova N.V., Moore N.M., Xia C.Q., Clare-Salzler M.J., Becker M.L., et al. The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates. Biomaterials 2010, 31:7444-7454.
14. Moore N.M., Lin N.J., Gallant N.D., Becker M.L. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials 2010, 31:1604-1611.
15. Gallant N.D., Lavery K.A., Amis E.J., Becker M.L. Universal gradient substrates for " click" biofunctionalization. Adv Mat 2007, 19:965-969.
16. Anderson D.G., Levenberg S., Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol 2004, 22:863-866.
17. Kou P.M., Babensee J.E. Validation of a high-throughput methodology to assess the effects of biomaterials on dendritic cell phenotype. Acta Biomater 2010, 6:2621-2630.
18. Petersen L.K., Sackett C.K., Narasimhan B. Novel, high throughput method to study in vitro protein release from polymer nanospheres. J Comb Chem 2010, 12:51-56.
19. Petersen L.K., Chavez-Santoscoy A.V., Narasimhan B. Combinatorial synthesis of and high-throughput protein release from polymer film and nanoparticle libraries. J Vis Exp 2012, 6:e3882.
20. Ali O.A., Huebsch N., Cao L., Dranoff G., Mooney D.J. Infection-mimicking materials to program dendritic cells in situ. Nat Mater 2009, 8:151-158.
21. Lü J.M., Wang X., Marin-Muller C., Wang H., Lin P.H., Yao Q., et al. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn 2009, 9:325-341.
22. Abbas A.O., Donovan M.D., Salem A.K. Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery. J Pharm Sci 2008, 97:2448-2461.
23. Gupta R.K., Chang A.C., Siber G.R. Biodegradable polymer microspheres as vaccine adjuvants and delivery systems. Dev Biol Stand 1998, 92:63-78.
24. Quintanar-Guerrero D., Ganem-Quintanar A., Allémann E., Fessi H., Doelker E. Influence of the stabilizer coating layer on the purification and freeze-drying of poly(D, L-lactic acid) nanoparticles prepared by an emulsion-diffusion technique. J Microencapsul 1998, 15:107-119.
25. Acharya A.P., Dolgova N.V., Clare-Salzler M.J., Keselowsky B.G. Adhesive substrate-modulation of adaptive immune responses. Biomaterials 2008, 29:4736-4750.
26. Acharya A.P., Dolgova N.V., Xia C.Q., Clare-Salzler M.J., Keselowsky B.G. Adhesive substrates modulate the activation and stimulatory capacity of non-obese diabetic mouse-derived dendritic cells. Acta Biomater 2011, 7:180-192.