Tumor necrosis factor-α promotes bile ductular transdifferentiation of mature rat hepatocytes in vitro

Journal of Cellular Biochemistry

Volumn 114, Issue 4, 2013, Pages 831-843

  Nishikawa, Yuji ^a   Sone, Masayuki ^b,c   Nagahama, Yasuharu ^a,c   Kumagai, Eriko ^c   Doi, Yuko ^c   Omori, Yasufumi ^c   Yoshioka, Toshiaki ^c   Tokairin, Takuo ^c   Yoshida, Masayuki ^c   Yamamoto, Yohei ^c   Ito, Akihiko ^d   Sugiyama, Toshihiro ^c   Enomoto, Katsuhiko ^c  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c AKITA UNIVERSITY   (Japan)

^d KINKI UNIVERSITY   (Japan)

Author keywords

BILE DUCT CELLS; DUCTULAR REACTION; HEPATOCYTES; JNK c JUN PATHWAY; LIVER FIBROSIS; TRANSDIFFERENTIATION; TUMOR NECROSIS FACTOR

Indexed keywords

ALBUMIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGEN TYPE 1; CYTOKERATIN 19; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; PROTEIN C JUN; SECRETIN; SPERMATOGENIC IMMUNOGLOBULIN SUPERFAMILY; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL MATURATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MALE; MORPHOGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SPHEROID CELL;

ALBUMINS; ANIMALS; ANTHRACENES; BILE DUCTS; CARBON TETRACHLORIDE; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL SHAPE; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; DRUG-INDUCED LIVER INJURY, CHRONIC; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; IMMUNOGLOBULINS; KERATIN-19; MALE; MAP KINASE SIGNALING SYSTEM; MORPHOGENESIS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, TRANSGENIC; RNA, MESSENGER; SECRETIN; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874226761     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24424     Document Type: Article

References (38)

1. Alvaro D, Mancino MG, Glaser S, Gaudio E, Marzioni M, Francis H, Alpini G,. 2007. Proliferating cholangiocytes: A neuroendocrine compartment in the diseased liver. Gastroenterology 132: 415-431.
2. Bahcecioglu IH, Koca SS, Poyrazoglu OK, Yalniz M, Ozercan IH, Ustundag B, Sahin K, Dagli AF, Isik A,. 2008. Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis. Inflammation 31: 215-221.
3. Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, Riley T, Howard TA, Michalopoulos GK,. 1996. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol 132: 1133-1149.
4. Bradham CA, Plumpe J, Manns MP, Brenner DA, Trautwein C,. 1998. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol 275: G387-G392.
5. Brenner DA, Buck M, Feitelberg SP, Chojkier M,. 1990. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. J Clin Invest 85: 248-255.
6. Buck M, Zhang L, Halasz NA, Hunter T, Chojkier M,. 2001. Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha. EMBO J 20: 6712-6723.
7. Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP,. 2002. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development 129: 1819-1828.
8. Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR,. 2005. Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis. Hepatology 41: 809-818.
9. Dean S, Tang JI, Seckl JR, Nyirenda MJ,. 2010. Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents. Gene Exp 14: 337-344.
10. Desmet V, Roskams T, Van Eyken P,. 1995. Ductular reaction in the liver. Pathol Res Pract 191: 513-524.
11. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, Bagby G, Nelson S,. 1994. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol 267: G552-G561.
12. Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG,. 1997. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26: 1530-1537.
13. Ito A, Nishikawa Y, Ohnuma K, Ohnuma I, Koma Y, Sato A, Enomoto K, Tsujimura T, Yokozaki H,. 2007. SgIGSF is a novel biliary-epithelial cell adhesion molecule mediating duct/ductule development. Hepatology 45: 684-694.
14. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baetscher M, Wang B, Bissell DM, Burkly LC,. 2005. TWEAK induces liver progenitor cell proliferation. J Clin Invest 115: 2330-2340.
15. Kamiya A, Gonzalez FJ,. 2004. TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology 40: 527-536.
16. Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, Kikuchi S, Ogasawara N, Ohkuni T, Masaki T, Hirata K, Himi T, Sawada N,. 2010. c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J Cell Physiol 225: 720-733.
17. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A,. 1995. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 146: 1220-1234.
18. LeSage GD, Benedetti A, Glaser S, Marucci L, Tretjak Z, Caligiuri A, Rodgers R, Phinizy JL, Baiocchi L, Francis H, Lasater J, Ugili L, Alpini G,. 1999. Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver. Hepatology 29: 307-319.
19. Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, Desimone C, Song XY, Diehl AM,. 2003. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37: 343-350.
20. Michalopoulos GK, Bowen WC, Mule K, Lopez-Talavera JC, Mars W,. 2002. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 36: 278-283.
21. Michalopoulos GK, Barua L, Bowen WC,. 2005. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 41: 535-544.
22. Nishikawa Y, Tokusashi Y, Kadohama T, Nishimori H, Ogawa K,. 1996. Hepatocytic cells form bile duct-like structures within a three-dimensional collagen gel matrix. Exp Cell Res 223: 357-371.
23. Nishikawa Y, Doi Y, Watanabe H, Tokairin T, Omori Y, Su M, Yoshioka T, Enomoto K,. 2005. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Am J Pathol 166: 1077-1088.
24. Richardson MM, Jonsson JR, Powell EE, Brunt EM, Neuschwander-Tetri BA, Bhathal PS, Dixon JB, Weltman MD, Tilg H, Moschen AR, Purdie DM, Demetris AJ, Clouston AD,. 2007. Progressive fibrosis in nonalcoholic steatohepatitis: Association with altered regeneration and a ductular reaction. Gastroenterology 133: 80-90.
25. Rolfe M, James NH, Roberts RA,. 1997. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: A mediator of the hepatocarcinogenicity of peroxisome proliferators ? Carcinogenesis 18: 2277-2280.
26. Roskams T,. 2003. Progenitor cell involvement in cirrhotic human liver diseases: From controversy to consensus. J Hepatol 39: 431-434.
27. Roskams TA, Theise ND, Balabaud C, Bhagat G, Bhathal PS, Bioulac-Sage P, Brunt EM, Crawford JM, Crosby HA, Desmet V, Finegold MJ, Geller SA, Gouw AS, Hytiroglou P, Knisely AS, Kojiro M, Lefkowitch JH, Nakanuma Y, Olynyk JK, Park YN, Portmann B, Saxena R, Scheuer PJ, Strain AJ, Thung SN, Wanless IR, West AB,. 2004. Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers. Hepatology 39: 1739-1745.
28. Sato Y, Igarashi Y, Hakamata Y, Murakami T, Kaneko T, Takahashi M, Seo N, Kobayashi E,. 2003. Establishment of Alb-DsRed2 transgenic rat for liver regeneration research. Biochem Biophys Res Commun 311: 478-481.
29. Sone M, Nishikawa Y, Nagahama Y, Kumagai E, Doi Y, Omori Y, Yoshioka T, Tokairin T, Yoshida M, Sugiyama T, Enomoto K,. 2012. Recovery of mature hepatocytic phenotype following bile ductular transdifferentiation of rat hepatocytes in vitro. Am J Pathol pii: S0002-9440(12)00676-1. DOI: 10.1016/j.ajpath.2012.08.034 [Epub ahead of print].
30. Tacke F, Luedde T, Trautwein C,. 2009. Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol 36: 4-12.
31. Tilg H, Kaser A, Moschen AR,. 2006. How to modulate inflammatory cytokines in liver diseases. Liver Int 26: 1029-1039.
32. Wullaert A, van Loo G, Heyninck K, Beyaert R,. 2007. Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: Effects on liver homeostasis and beyond. Endocr Rev 28: 365-386.
33. Xia Y, Karin M,. 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol 14: 94-101.
34. Xian ZH, Cong WM, Wang YH, Wang B, Wu MC,. 2009. Expression and localization of aquaporin-1 in human cirrhotic liver. Pathol Res Pract 205: 774-780.
35. Yamada Y, Fausto N,. 1998. Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol 152: 1577-1589.
36. Yamada Y, Kirillova I, Peschon JJ, Fausto N,. 1997. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 94: 1441-1446.
37. Yamada Y, Webber EM, Kirillova I, Peschon JJ, Fausto N,. 1998. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor. Hepatology 28: 959-970.
38. Yamaguchi M, Yahata T, Fujita K, Sakurada J, Hasegawa G, Umezu H, Naito M, Tanaka K,. 2009. Extranodal Rosai-Dorfman disease involving bilateral ovaries in a patient with a ventriculoperitoneal shunt. J Obstet Gynaecol Res 35: 1000-1003.