Mouse Zygotes Respond to Severe Sperm DNA Damage by Delaying Paternal DNA Replication and Embryonic Development

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Gawecka, Joanna E ^a   Marh, Joel ^a   Ortega, Michael ^a   Yamauchi, Yasuhiro ^a   Ward, Monika A ^a   Ward, W Steven ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; DNA TOPOISOMERASE (ATP HYDROLYSING); GAMMA HISTONE H2AX; HISTONE H2AX; MANGANESE; TOPOISOMERASE 2B; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLASTOCYST; CELL CYCLE S PHASE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DNA DEGRADATION; DNA FRAGMENTATION; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; EMBRYO; EMBRYO DEVELOPMENT; EPIDIDYMIS TAIL; FEMALE; FERTILIZATION; G2 PHASE CELL CYCLE CHECKPOINT; MALE; MOLECULAR RECOGNITION; MOUSE; NICK END LABELING; NONHUMAN; PRONUCLEUS; SEX CHROMOSOME ABERRATION; SPERM CHROMATIN FRAGMENTATION; VAS DEFERENS; ZYGOTE;

ANIMALS; CELL NUCLEUS; CHROMATIN; DNA FRAGMENTATION; DNA REPLICATION; EMBRYONIC DEVELOPMENT; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HISTONES; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; SPERM INJECTIONS, INTRACYTOPLASMIC; SPERMATOZOA; ZYGOTE;

EID: 84874220447     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056385     Document Type: Article

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