Cardiac-Specific Overexpression of Metallothionein Rescues against Cigarette Smoking Exposure-Induced Myocardial Contractile and Mitochondrial Damage

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Hu, Nan ^a   Han, Xuefeng ^a,b   Lane, Erin K ^a   Gao, Feng ^b   Zhang, Yingmei ^a,b   Ren, Jun ^a,b  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACONITATE HYDRATASE; CASPASE 12; CASPASE 3; CASPASE 9; CIGARETTE SMOKE; CYTOCHROME C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; METALLOTHIONEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; WORTMANNIN;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL DAMAGE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROSIS; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE SIZE; LONG TERM EXPOSURE; MALE; MITOCHONDRION; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; SMOKING;

ACONITATE HYDRATASE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CARDIOVASCULAR DISEASES; CELLS, CULTURED; CYTOCHROMES C; FIBROSIS; MALE; METALLOTHIONEIN; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE TYPE III; ORGAN SPECIFICITY; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SMOKING; TOBACCO SMOKE POLLUTION;

EID: 84874219393     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057151     Document Type: Article

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