메뉴 건너뛰기




Volumn 38, Issue 2, 2013, Pages 109-115

Cardiometabolic consequences of therapy for chronic schizophrenia using second-generation antipsychotic agents in a Medicaid population: Clinical and economic evaluation

Author keywords

Cardiometabolic; Medicaid; Schizophrenia; Second generation antipsychotic agents

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; RISPERIDONE; TRIACYLGLYCEROL; ZIPRASIDONE;

EID: 84874132424     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (43)
  • 1
    • 26644472427 scopus 로고    scopus 로고
    • The economic burden of schizophrenia in the United States in 2002
    • Wu EQ, Birnbaum HG, Shi L, et al. The economic burden of schizophrenia in the United States in 2002. J Clin Psychiatry 2005;66(9):1122-1129.
    • (2005) J Clin Psychiatry , vol.66 , Issue.9 , pp. 1122-1129
    • Wu, E.Q.1    Birnbaum, H.G.2    Shi, L.3
  • 2
    • 0033112123 scopus 로고    scopus 로고
    • Information needs for medication coverage decisions in a state Medicaid program
    • Croghan TW, Johnstone BM, Buesching DP, Kessler RC. Information needs for medication coverage decisions in a state Medicaid program. Med Care 1999;37(4 Suppl):AS24-AS31.
    • (1999) Med Care , vol.37 , Issue.4 SUPPL.
    • Croghan, T.W.1    Johnstone, B.M.2    Buesching, D.P.3    Kessler, R.C.4
  • 3
    • 0004167603 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services, 2006. Available at, Accessed November 1
    • U.S. Department of Health and Human Services. Schizophrenia. 2006. Available at: www.nimh.nih.gov/health/publications/index. shtml. Accessed November 1, 2011.
    • (2011) Schizophrenia
  • 5
    • 4444242571 scopus 로고    scopus 로고
    • Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications
    • Leslie DL, Rosenheck RA. Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications. Am J Psychiatry 2004;161(9):1709-1711.
    • (2004) Am J Psychiatry , vol.161 , Issue.9 , pp. 1709-1711
    • Leslie, D.L.1    Rosenheck, R.A.2
  • 6
    • 71549163794 scopus 로고    scopus 로고
    • Metabolic risk factors among Medicaid outpatients with schizophrenia receiving secondgeneration antipsychotics
    • Bell RC, Farmer S, Ries R, Srebnik D. Metabolic risk factors among Medicaid outpatients with schizophrenia receiving secondgeneration antipsychotics. Psychiatric Serv 2009;60(12):1686-1689.
    • (2009) Psychiatric Serv , vol.60 , Issue.12 , pp. 1686-1689
    • Bell, R.C.1    Farmer, S.2    Ries, R.3    Srebnik, D.4
  • 7
    • 0347615169 scopus 로고    scopus 로고
    • Metabolic issues with atypical antipsychotics in primary care: Dispelling the myths
    • Kabinoff GS, Toalson PA, Healey KM, et al Metabolic issues with atypical antipsychotics in primary care: Dispelling the myths. Prim Care Companion J Clin Psychiatry 2003;5(1):6-14.
    • (2003) Prim Care Companion J Clin Psychiatry , vol.5 , Issue.1 , pp. 6-14
    • Kabinoff, G.S.1    Toalson, P.A.2    Healey, K.M.3
  • 8
    • 23044457006 scopus 로고    scopus 로고
    • Identifying individuals at high risk for diabetes: The Atherosclerosis Risk in Communities study
    • Schmidt MI, Duncan BB, Bang H, et al. Identifying individuals at high risk for diabetes: The Atherosclerosis Risk in Communities study. Diabetes Care 2005;28(8):2013-2018.
    • (2005) Diabetes Care , vol.28 , Issue.8 , pp. 2013-2018
    • Schmidt, M.I.1    Duncan, B.B.2    Bang, H.3
  • 9
    • 47649104964 scopus 로고    scopus 로고
    • Prediction of first events of coronary heart disease and stroke with consideration of adiposity
    • Wilson PW, Bozeman SR, Burton TM, et al. Prediction of first events of coronary heart disease and stroke with consideration of adiposity. Circulation 2008;118(2):124-130.
    • (2008) Circulation , vol.118 , Issue.2 , pp. 124-130
    • Wilson, P.W.1    Bozeman, S.R.2    Burton, T.M.3
  • 10
    • 27744581955 scopus 로고    scopus 로고
    • A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls
    • Goff DC, Sullivan LM, McEvoy JP, et al. A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls. Schizophrenia Res 2005;80(1):45-53.
    • (2005) Schizophrenia Res , vol.80 , Issue.1 , pp. 45-53
    • Goff, D.C.1    Sullivan, L.M.2    McEvoy, J.P.3
  • 11
    • 25144456112 scopus 로고    scopus 로고
    • Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    • Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353(12):1209-1223.
    • (2005) N Engl J Med , vol.353 , Issue.12 , pp. 1209-1223
    • Lieberman, J.A.1    Stroup, T.S.2    McEvoy, J.P.3
  • 12
    • 0033980090 scopus 로고    scopus 로고
    • Primary and subsequent coronary risk appraisal: New results from the Framingham study
    • D'Agostino RB, Russell MW, Huse DM, et al. Primary and subsequent coronary risk appraisal: New results from the Framingham study. Am Heart J 2000;139(2 Part 1):272-281.
    • (2000) Am Heart J , vol.139 , Issue.2 PART 1 , pp. 272-281
    • D'Agostino, R.B.1    Russell, M.W.2    Huse, D.M.3
  • 13
    • 84874730944 scopus 로고    scopus 로고
    • Accessed November 3, Agency for Healthcare Research and Quality (AHRQ), Nationwide Inpatient Sample. 2008. Available at:
    • Agency for Healthcare Research and Quality (AHRQ). Statistics on Hospital Stays. Nationwide Inpatient Sample. 2008. Available at: http://hcupnet.ahrq.gov. Accessed November 3, 2011.
    • (2011) Statistics on Hospital Stays
  • 14
    • 85081776687 scopus 로고    scopus 로고
    • Accessed April 1, Available at:
    • Angina pectoris. 2011. Available at: www.emedicinehealth.com/ angina_pectoris/page8_em.htm. Accessed April 1, 2011.
    • (2011) Angina pectoris
  • 15
    • 84867056744 scopus 로고    scopus 로고
    • Accessed April 1, Available at:
    • Coronary Artery Disease. 2011. Available at: www.emedicinehealth. com/coronary_artery_disease-health/page13_em.htm. Accessed April 1, 2011.
    • (2011) Coronary Artery Disease
  • 16
    • 84874132101 scopus 로고    scopus 로고
    • Accessed April 1, Agency for Health Care Administration, 2011. Available at:
    • Agency for Health Care Administration. Florida Medicaid, Summary of Services, Fiscal Year 10/11. 2011. Available at: www.ahca.myflorida. com/Medicaid/flmedicaid.shtml. Accessed April 1, 2011.
    • (2011) Florida Medicaid, Summary of Services, Fiscal Year 10/11
  • 17
    • 85081779407 scopus 로고    scopus 로고
    • Accessed April 4, Agency for Healthcare Research and Quality (AHRQ), 2011. Available at:
    • Agency for Healthcare Research and Quality (AHRQ). Medical Panel Expenditure Survey. 2011. Available at: http://meps.ahrq. gov/mepsweb. Accessed April 4, 2011.
    • (2011) Medical Panel Expenditure Survey
  • 18
    • 85081782875 scopus 로고    scopus 로고
    • Accessed April 1, Consumer Price Index (CPI), 2011. Available at:
    • Consumer Price Index (CPI). Series cuur0000sam. 2011. Available at: www.bls.gov/cpi. Accessed April 1, 2011.
    • (2011) Series cuur0000sam
  • 19
    • 84917038127 scopus 로고    scopus 로고
    • Accessed January 2, Montvale, N.J.: PDR Network, LLC.; 2011, Available at:
    • Red Book. Montvale, N.J.: PDR Network, LLC.; 2011. Available at: www.pdr.net. Accessed January 2, 2013.
    • (2013) Red Book
  • 20
    • 73649122825 scopus 로고    scopus 로고
    • Metabolic testing rates in 3 state Medicaid programs after FDA warnings and ADA/APA recommendations for second-generation antipsychotic drugs
    • Morrato EH, Druss B, Hartung DM, et al. Metabolic testing rates in 3 state Medicaid programs after FDA warnings and ADA/APA recommendations for second-generation antipsychotic drugs. Arch Gen Psychiatry 2010;67(1):17-24.
    • (2010) Arch Gen Psychiatry , vol.67 , Issue.1 , pp. 17-24
    • Morrato, E.H.1    Druss, B.2    Hartung, D.M.3
  • 21
    • 67349119802 scopus 로고    scopus 로고
    • UK cost-consequence analysis of aripiprazole in schizophrenia: Diabetes and coronary heart disease risk projections (STAR study)
    • Barnett AH, Millar HL, Loze JY, et al. UK cost-consequence analysis of aripiprazole in schizophrenia: Diabetes and coronary heart disease risk projections (STAR study). Eur Arch Psychiatry Clin Neurosci 2009;259(4):239-247.
    • (2009) Eur Arch Psychiatry Clin Neurosci , vol.259 , Issue.4 , pp. 239-247
    • Barnett, A.H.1    Millar, H.L.2    Loze, J.Y.3
  • 22
    • 63449107854 scopus 로고    scopus 로고
    • Cost-consequence of diabetes and coronary heart disease in patients with schizophrenia in Germany: A social and health insurance perspective
    • Neubauer AS, Deuschle M, Marschall D, et al. Cost-consequence of diabetes and coronary heart disease in patients with schizophrenia in Germany: A social and health insurance perspective. Gesundheitsokonomie Qualitatsmanage 2009;14(2):95-103.
    • (2009) Gesundheitsokonomie Qualitatsmanage , vol.14 , Issue.2 , pp. 95-103
    • Neubauer, A.S.1    Deuschle, M.2    Marschall, D.3
  • 23
    • 33845712554 scopus 로고    scopus 로고
    • Change in Framingham risk score in patients with schizophrenia: A post hoc analysis of a randomized, double-blind, 6-week trial of ziprasidone and olanzapine
    • Del Valle MC, Loebel AD, Murray S, et al. Change in Framingham risk score in patients with schizophrenia: A post hoc analysis of a randomized, double-blind, 6-week trial of ziprasidone and olanzapine. Prim Care Companion J Clin Psychiatry 2006;8(6):329-333.
    • (2006) Prim Care Companion J Clin Psychiatry , vol.8 , Issue.6 , pp. 329-333
    • del Valle, M.C.1    Loebel, A.D.2    Murray, S.3
  • 24
    • 54849381700 scopus 로고    scopus 로고
    • Antipsychotic effects on estimated 10-year coronary heart disease risk in the CATIE schizophrenia study
    • Daumit GL, Goff DC, Meyer JM, et al. Antipsychotic effects on estimated 10-year coronary heart disease risk in the CATIE schizophrenia study. Schizophr Res 2008;105(1-3):175-187.
    • (2008) Schizophr Res , vol.105 , Issue.1-3 , pp. 175-187
    • Daumit, G.L.1    Goff, D.C.2    Meyer, J.M.3
  • 25
    • 33646463345 scopus 로고    scopus 로고
    • Cost-effectiveness of olanzapine as first-line treatment for schizophrenia: Results from a randomized, open-label, 1-year trial
    • Tunis SL, Faries DE, Nyhuis AW, et al. Cost-effectiveness of olanzapine as first-line treatment for schizophrenia: Results from a randomized, open-label, 1-year trial. Value Health 2006;9(2):77-89.
    • (2006) Value Health , vol.9 , Issue.2 , pp. 77-89
    • Tunis, S.L.1    Faries, D.E.2    Nyhuis, A.W.3
  • 26
    • 33846276906 scopus 로고    scopus 로고
    • Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia
    • Rosenheck RA, Leslie DL, Sindelar J, et al. Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia. Am J Psychiatry 2006;163(12):2080-2089.
    • (2006) Am J Psychiatry , vol.163 , Issue.12 , pp. 2080-2089
    • Rosenheck, R.A.1    Leslie, D.L.2    Sindelar, J.3
  • 27
    • 34447131002 scopus 로고    scopus 로고
    • Cost-effectiveness of first-v. second-generation antipsychotic drugs: Results from a randomised controlled trial in schizophrenia responding poorly to previous therapy
    • Davies LM, Lewis S, Jones PB, et al. Cost-effectiveness of first-v. second-generation antipsychotic drugs: Results from a randomised controlled trial in schizophrenia responding poorly to previous therapy. Br J Psychiatry 2007;191:14-22.
    • (2007) Br J Psychiatry , vol.191 , pp. 14-22
    • Davies, L.M.1    Lewis, S.2    Jones, P.B.3
  • 28
    • 78650329688 scopus 로고    scopus 로고
    • Cost-effectiveness of olanzapine vs. aripiprazole in the treatment of schizophrenia
    • Ascher-Svanum H, Stensland MD, Peng X, et al. Cost-effectiveness of olanzapine vs. aripiprazole in the treatment of schizophrenia. Curr Med Res Opin 2011;27(1):115-122.
    • (2011) Curr Med Res Opin , vol.27 , Issue.1 , pp. 115-122
    • Ascher-Svanum, H.1    Stensland, M.D.2    Peng, X.3
  • 29
    • 77954648452 scopus 로고    scopus 로고
    • Comparison of the metabolic and economic consequences of long-term treatment of schizophrenia using ziprasidone, olanzapine, quetiapine, and risperidone in Canada: A cost-effectiveness analysis
    • McIntyre RS, Cragin L, Sorensen S, et al. Comparison of the metabolic and economic consequences of long-term treatment of schizophrenia using ziprasidone, olanzapine, quetiapine, and risperidone in Canada: A cost-effectiveness analysis. J Eval Clin Pract 2010;16(4):744-755.
    • (2010) J Eval Clin Pract , vol.16 , Issue.4 , pp. 744-755
    • McIntyre, R.S.1    Cragin, L.2    Sorensen, S.3
  • 30
    • 85081781944 scopus 로고    scopus 로고
    • Accessed January 2, Indianapolis: Eli Lilly; revised June 2, 2011, Available at:
    • Zyprexa (olanzapine), package insert/full prescribing information. Indianapolis: Eli Lilly; revised June 2, 2011. Available at: http:// pi.lilly.com/us/zyprexa-pi.pdf. Accessed January 2, 2013.
    • (2013) Zyprexa (olanzapine), package insert/full prescribing information
  • 31
    • 33845320133 scopus 로고    scopus 로고
    • Does antipsychotic polypharmacy increase the risk for metabolic syndrome?
    • Correll CU, Frederickson AM, Kane JM, Manu P. Does antipsychotic polypharmacy increase the risk for metabolic syndrome? Schizophr Res 2007;89(1-3):91-100.
    • (2007) Schizophr Res , vol.89 , Issue.1-3 , pp. 91-100
    • Correll, C.U.1    Frederickson, A.M.2    Kane, J.M.3    Manu, P.4
  • 32
    • 34547221039 scopus 로고    scopus 로고
    • Antipsychotic polypharmacy trends among Medicaid beneficiaries with schizophrenia in San Diego County, 1999-2004
    • Gilmer TP, Dolder CR, Folsom DP, et al. Antipsychotic polypharmacy trends among Medicaid beneficiaries with schizophrenia in San Diego County, 1999-2004. Psychiatr Serv 2007;58(7):1007-1010.
    • (2007) Psychiatr Serv , vol.58 , Issue.7 , pp. 1007-1010
    • Gilmer, T.P.1    Dolder, C.R.2    Folsom, D.P.3
  • 33
    • 79960684945 scopus 로고    scopus 로고
    • Is antipsychotic polypharmacy associated with metabolic syndrome even after adjustment for lifestyle effects?: A cross-sectional study
    • Misawa F, Shimizu K, Fujii Y, et al. Is antipsychotic polypharmacy associated with metabolic syndrome even after adjustment for lifestyle effects?: A cross-sectional study. BMC Psychiatry 2011;11:118.
    • (2011) BMC Psychiatry , vol.11 , pp. 118
    • Misawa, F.1    Shimizu, K.2    Fujii, Y.3
  • 34
    • 70349217937 scopus 로고    scopus 로고
    • Cardiovascular disease and diabetes in people with severe mental illness. Position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC)
    • De Hert M, Dekker JM, Wood D, et al. Cardiovascular disease and diabetes in people with severe mental illness. Position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry 2009;24(6):412-424.
    • (2009) Eur Psychiatry , vol.24 , Issue.6 , pp. 412-424
    • de Hert, M.1    Dekker, J.M.2    Wood, D.3
  • 35
    • 62549099817 scopus 로고    scopus 로고
    • Epidemiological study for the evaluation of metabolic disorders in patients with schizophrenia: The METEOR study
    • De Hert M, Falissard B, Mauri M, et al. Epidemiological study for the evaluation of metabolic disorders in patients with schizophrenia: The METEOR study. European Neuropsychopharmacol 2008;18(S4):S444-S445.
    • (2008) European Neuropsychopharmacol , vol.18 , Issue.S4
    • de Hert, M.1    Falissard, B.2    Mauri, M.3
  • 37
    • 38849103726 scopus 로고    scopus 로고
    • Metabolic comorbidity in schizophrenia
    • Jacob R, Chowdhury AN. Metabolic comorbidity in schizophrenia. Indian J Med Sci 2008;62(1):23-31.
    • (2008) Indian J Med Sci , vol.62 , Issue.1 , pp. 23-31
    • Jacob, R.1    Chowdhury, A.N.2
  • 38
    • 56849102843 scopus 로고    scopus 로고
    • Metabolic syndrome and atypical antipsychotics: A selective literature review
    • Kannabiran M, Singh V. Metabolic syndrome and atypical antipsychotics: A selective literature review. German J Psychiatry 2008;11(3):111-122.
    • (2008) German J Psychiatry , vol.11 , Issue.3 , pp. 111-122
    • Kannabiran, M.1    Singh, V.2
  • 39
    • 27744502054 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III
    • McEvoy JP, Meyer JM, Goff DC, et al. Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. Schizophr Res 2005;80(1):19-32.
    • (2005) Schizophr Res , vol.80 , Issue.1 , pp. 19-32
    • McEvoy, J.P.1    Meyer, J.M.2    Goff, D.C.3
  • 40
    • 43049092201 scopus 로고    scopus 로고
    • Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: Prospective data from phase 1
    • Meyer JM, Davis VG, Goff DC, et al. Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: Prospective data from phase 1. Schizophrenia Res 2008;101(1-3):273-286.
    • (2008) Schizophrenia Res , vol.101 , Issue.1-3 , pp. 273-286
    • Meyer, J.M.1    Davis, V.G.2    Goff, D.C.3
  • 41
    • 85081777606 scopus 로고    scopus 로고
    • Cardio-metabolic risk profiles of community psychiatric patients in North Tyneside, United Kingdom
    • Nulkar A, Watkinson HMO, Waton A, Mackin P. Cardio-metabolic risk profiles of community psychiatric patients in North Tyneside, United Kingdom. J Cancer Educ 2009;24:S535.
    • (2009) J Cancer Educ , vol.24
    • Nulkar, A.1    Watkinson, H.M.O.2    Waton, A.3    McKin, P.4
  • 42
    • 33750704276 scopus 로고    scopus 로고
    • The metabolic syndrome and schizophrenia: The latest evidence and nursing guidelines for management
    • Usher K, Foster K, Park T. The metabolic syndrome and schizophrenia: The latest evidence and nursing guidelines for management. J Psychiatric Mental Health Nurs 2006;13(6):730-734.
    • (2006) J Psychiatric Mental Health Nurs , vol.13 , Issue.6 , pp. 730-734
    • Usher, K.1    Foster, K.2    Park, T.3
  • 43
    • 42249106663 scopus 로고    scopus 로고
    • Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder
    • van Winkel R, De Hert M, Wampers M, et al. Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry 2008;69(3):472-479.
    • (2008) J Clin Psychiatry , vol.69 , Issue.3 , pp. 472-479
    • van Winkel, R.1    de Hert, M.2    Wampers, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.