Impact of multidrug resistance on Pseudomonas aeruginosa ventilator-associated pneumonia outcome: Predictors of early and crude mortality

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 32, Issue 3, 2013, Pages 413-420

  Pena C ^a   Gomez Zorrilla S ^a   Oriol, I ^a   Tubau, F ^a   Dominguez, M A ^a   Pujol, M ^a   Ariza, J ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AZTREONAM; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; FOSFOMYCIN; GENTAMICIN; IMIPENEM; MEROPENEM; OFLOXACIN; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG SENSITIVITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIDRUG RESISTANCE; MULTIPLE ORGAN FAILURE; NONHUMAN; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS PNEUMONIA; VENTILATOR ASSOCIATED PNEUMONIA;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; PROGNOSIS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84874113830     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-012-1758-8     Document Type: Article

References (31)

1. Niederman MS, Craven DE, Bonten MJ, Chastre J, Craig WA, Fagon JY et al (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388-416
2. Eggimann P, Revelly JP (2006) Should antibiotic combinations be used to treat ventilator-associated pneumonia? Semin Respir Crit Care Med 27:68-81
3. Garnacho-Montero J, Sa-Borges M, Sole-Violan J, Barcenilla F, Escoresca-Ortega A, Ochoa M et al (2007) Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: an observational, multicenter study comparing monotherapy with combination antibiotic therapy. Crit Care Med 35:1888-1895
4. Heyland DK, Cook DJ, Griffith L, Keenan SP, Brun-Buisson C; Canadian Critical Trials Group (1999) The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. Am J Resp Crit Care Med 159:1249-1256
5. Gursel G, Demirtas S (2006) Value of APACHE II, SOFA and CPIS scores in predicting prognosis in patients with ventilator-associated pneumonia. Respiration 73:503-508
6. Kollef MH, Silver P, Murphy DM, Trovillion E (1995) The effect of late-onset ventilator-associated pneumonia in determining patient mortality. Chest 106:1655-1662
7. Luna CM, Videla A, Mattera J, Vay C, Famiglietti A, Vujacich P et al (1999) Blood cultures have limited value in predicting severity of illness and as a diagnostic tool in ventilator-associated pneumonia. Chest 116:1075-1084
8. Luna CM, Aruj P, Niederman MS, Garzón J, Violi D, Prignoni A et al (2006) Appropriateness and delay to initiate therapy in ventilator-associated pneumonia. Eur Respir J 27:158-164
9. Garnacho-Montero J, Ortiz-Leyba C, Jiménez-Jiménez FJ, Barrero-Almodóvar AE, García-Garmendia JL, Bernabeu-Wittell M et al (2003) Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP. Clin Infect Dis 36:1111-1118
10. Reina R, Estenssoro E, Sáenz G, Canales HS, Gonzalvo R, Vidal G et al (2005) Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study. Intensive Care Med 31:1058-1065
11. Rios FG, Luna CM, Maskin B, Saenz Valiente A, Lloria M, Gando S et al (2007) Ventilator-associated pneumonia due to colistin susceptible-only microorganisms. Eur Respir J 30:307-313
12. Peña C, Suarez C, Gozalo M, Murillas J, Almirante B, Pomar V et al; Spanish Network for research in Infectious Diseases (REIPI) (2012) Prospective multicenter study of the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa bloodstream infections. Antimicrob Agents Chemother 56:1256-1272
13. Lodise TP, Miller CD, Graves J, Furuno JP, McGregor JC, Lomaestro B et al (2007) Clinical prediction tool to identify patients with Pseudomonas aeruginosa respiratory tract infections at greatest risk for multidrug resistance. Antimicrob Agents Chemother 51:417-422
14. Parker CM, Kutsogiannis J, Muscedere J, Cook D, Dodek P, Day AG et al; Canadian Critical Care Trials Group (2008) Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: prevalence, incidence, risk factors, and outcomes. J Crit Care 23:18-26
15. Florescu DF, Qiu F, McCartan MA, Mindru C, Fey PD, Kalil AC (2012) What is the efficacy and safety of colistin for the treatment of ventilator- associated pneumonia? A systematic review and meta-regression. Clin Infect Dis 54:670-680
16. Suarez C, Peña C, Arch O, Dominguez MA, Tubau F, Juan C et al (2011) A large sustained endemic outbreak of multiresistant Pseudomonas aeruginosa: a new epidemiological scenario for nosocomial acquisition. BMC Infect Dis 11:272
17. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM (1991) Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 143:1121-1129
18. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373-383
19. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874
20. Le Gall JR, Loirat P, Alperovitch A, Glaser P, Granthil C, Mathieu D et al (1984) A simplified acute physiology score for ICU patients. Crit Care Med 12:975-977
21. Niederman MS (2010) Hospital-acquired pneumonia, health care-associated pneumonia, ventilator-associated pneumonia, and ventilator-associated tracheobronchitis: definitions and challenges in trial design. Clin Infect Dis 51(Suppl 1):S12-S17
22. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters (2008) [updated 27 April, 2010; last accessed 29 October, 2010]. Available online at: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST-files/Disk-test-documents/ EUCAST-breakpoints-v1.1
23. Clinical and Laboratory Standards Institute (CLSI) (2012) Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. CLSI document M100-S22. CLSI, Wayne, PA
24. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268-281
25. Combes A, Luyt CE, Fagon JY, Wolff M, Trouillet JL, Chastre J (2007) Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia. Crit Care Med 35:146-154
26. Combes A, Luyt CE, Fagon JY, Wollf M, Trouillet JL, Gibert C et al; PNEUMA Trial Group (2004) Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia. Am J Respir Crit Care Med 170:786-792
27. Combes A, Luyt CE, Fagon JY, Wolff M, Trouillet JL, Chastre J (2006) Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumonia. Intensive Care Med 32:1970-1978
28. Gursel G, Aydogdu M, Ozyilmaz E, Ozis TN (2008) Risk factors for treatment failure in patients with ventilator-associated pneumonia receiving appropriate antibiotic therapy. J Crit Care 23:34-40
29. Deptuła A, Gospodarek E (2010) Reduced expression of virulence factors in multidrug-resistant Pseudomonas aeruginosa strains. Arch Microbiol 192:79-84
30. Dupont H, Montravers P, Gauzit R, Veber B, Pouriat JL, Martin C; Club d'Infectiologie en Anesthésie-Réanimation (2003) Outcome of postoperative pneumonia in the Eole study. Intensive Care Med 29:179-188
31. Garnacho-Montero J, Ortiz-Leyba C, Fernández-Hinojosa E, Aldabó-Pallás T, Cayuela A, Márquez-Vácaro JA et al (2005) Acinetobacter baumannii ventilator-associated pneumonia: epidemiological and clinical findings. Intensive Care Med 31:649-655