Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice

BioMetals

Volumn 25, Issue 6, 2012, Pages 1167-1175

  Kumfu, Sirinart ^a   Chattipakorn, Siriporn ^a,b   Fucharoen, Suthat ^c   Chattipakorn, Nipon ^a,b  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Cardiac mitochondria; Iron overload; MCU; Mitochondrial dysfunction; Thalassemia

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN A; FERROUS ION; MITOCHONDRIAL CALCIUM UNIPORTER BLOCKER; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE BLOCKER; REACTIVE OXYGEN METABOLITE; RU 360; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA THALASSEMIA; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; HEART MITOCHONDRION; HEART PROTECTION; INTRACELLULAR TRANSPORT; IRON OVERLOAD; IRON TRANSPORT; MITOCHONDRIAL DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; THALASSEMIA; TRANSGENIC MOUSE;

ANIMALS; BETA-THALASSEMIA; CALCIUM; CALCIUM CHANNELS; CARDIOTONIC AGENTS; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FERROUS COMPOUNDS; IRON OVERLOAD; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANES; REACTIVE OXYGEN SPECIES; RUTHENIUM COMPOUNDS;

MUS;

EID: 84874112168     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9579-x     Document Type: Article

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