Immobilization increases interleukin-6, but not tumour necrosis factor-α, release from the leg during exercise in humans

Experimental Physiology

Volumn 98, Issue 3, 2013, Pages 778-783

  Reihmane, Dace ^a,b   Hansen, Andreas Vigelsø ^a   Gram, Martin ^a   Kuhlman, Anja Birk ^a   Nørregaard, Jesper ^a   Pedersen, Helene Pape ^a   Lund, Michael Taulo ^a   Helge, Jørn Wulff ^a   Dela, Flemming ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF LATVIA   (Latvia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; CYTOKINE RELEASE; DOPPLER FLOWMETRY; HUMAN; IMMOBILIZATION; LEG BLOOD FLOW; LEG EXERCISE; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; VENOUS BLOOD;

EID: 84874108078     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2012.069211     Document Type: Article

References (25)

1. Andersen P, Adams RP, Sjøgaard G, Thorboe A & Saltin B (1985). Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59, 1647-1653.
2. Bruunsgaard H, Galbo H, Halkjaer-Kristensen J, Johansen TL, MacLean DA & Pedersen BK (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. J Physiol 499, 833-841.
3. Dela F, Mikines KJ, Larsen JJ & Galbo H (1996). Glucose clearance in aged trained skeletal muscle during maximal insulin with superimposed exercise. J Appl Physiol 87, 2059-2067.
4. Febbraio MA, Steensberg A, Starkie RL, McConell GK & Kingwell BA (2003). Skeletal muscle interleukin-6 and tumor necrosis factor-α release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism 52, 939-944.
5. Fischer CP, Plomgaard P, Hansen AK, Pilegaard H, Saltin B & Pedersen BK (2004). Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Am J Physiol Endocrinol Metab 287, E1189-E1194.
6. Gokhale R, Chandrashekara S & Vasanthakumar KC (2007). Cytokine response to strenuous exercise in athletes and non-athletes-an adaptive response. Cytokine 40, 123-127.
7. Gomez-Merino D, Drogou C, Guezennec CY, Burnat P, Bourrilhon C, Tomaszewski A, Milhau S & Chennaoui M (2006). Comparison of systemic cytokine responses after a long distance triathlon and a 100-km run: relationship to metabolic and inflammatory processes. Eur Cytokine Netw 17, 117-124.
8. Helge JW, Klein DK, Andersen TM, van Hall G, Calbet J, Boushel R & Saltin B (2011). Interleukin-6 release is higher across arm than leg muscles during whole-body exercise. Exp Physiol 96, 590-598.
9. Helge JW, Stallknecht B, Pedersen BK, Galbo H, Kiens B & Richter EA (2003). The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 546, 299-305.
10. Hiscock N, Chan MH, Bisucci T, Darby IA & Febbraio MA (2004). Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J 18, 992-994.
11. Jammes Y, Steinberg JG, Delliaux S & Brégeon F (2009). Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. J Intern Med 266, 196-206.
12. Kimura H, Suzui M, Nagao F & Matsumoto K (2001). Highly sensitive determination of plasma cytokines by time-resolved fluoroimmunoassay; effect of bicycle exercise on plasma level of interleukin-1α (IL-1α), tumor necrosis factor α (TNF α), and interferon γ (IFN γ). Anal Sci 17, 593-597.
13. MacDonald C, Wojtaszewski JF, Pedersen BK, Kiens B & Richter EA (2003). Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity. J Appl Physiol 95, 2273-2277.
14. Mäestu J, Jürimäe J, Purge P, Rämson R & Jürimäe T (2010). Performance improvement is associated with higher postexercise responses in interleukin-6 and tumor necrosis factor concentrations. J Sports Med Phys Fitness 50, 524-529.
15. Nieman DC, Davis JM, Henson DA, Gross SJ, Dumke CL, Utter AC, Vinci DM, Carson JA, Brown A, McAnulty SR, McAnulty LS & Triplett NT (2005). Muscle cytokine mRNA changes after 2.5 h of cycling: influence of carbohydrate. Med Sci Sports Exerc 37, 1283-1290.
16. Nieman DC, Davis JM, Henson DA, Walberg-Rankin J, Shute M, Dumke CL, Utter AC, Vinci DM, Carson JA, Brown A, Lee WJ, McAnulty SR & McAnulty LS (2003). Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J Appl Physiol 94, 1917-1925.
17. Nieman DC, Henson DA, Smith LL, Utter AC, Vinci DM, Davis JM, Kaminsky DE & Shute M (2001). Cytokine changes after a marathon race. J Appl Physiol 91, 109-114.
18. Ostrowski K, Schjerling P & Pedersen BK (2000). Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. Eur J Appl Physiol 83, 512-515.
19. Stallknecht B, Dela F & Helge JW (2007). Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans Am J Physiol Endocrinol Metab 292, E394-E399.
20. Starkie RL, Rolland J, Angus DJ, Anderson MJ & Febbraio MA (2001). Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running. Am J Physiol Cell Physiol 280, C769-C774.
21. Steensberg A, Keller C, Starkie RL, Osada T, Febbraio MA & Pedersen BK (2002). IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab 283, E1272-E1278.
22. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B & Klarlund PB (2000). Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529, 237-242.
23. Suzuki K, Nakaji S, Yamada M, Liu Q, Kurakake S, Okamura N, Kumae T, Umeda T & Sugawara K (2003). Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc 35, 348-355.
24. Toft AD, Thorn M, Ostrowski K, Asp S, Moller K, Iversen S, Hermann C, Sondergaard SR & Pedersen BK (2000). N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise. J Appl Physiol 89, 2401-2406.
25. Youd JM, Rattigan S & Clark MG (2000). Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-α. Diabetes 49, 1904-1909.