Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 40, Issue 2, 2013, Pages 245-253

  Zanotti Fregonara, Paolo ^a   Barth, Vanessa N ^b   Liow, Jeih San ^a   Zoghbi, Sami S ^a   Clark, David T ^a   Rhoads, Emily ^b   Siuda, Edward ^b   Heinz, Beverly A ^b   Nisenbaum, Eric ^b   Dressman, Bruce ^b   Joshi, Elizabeth ^b   Luffer Atlas, Debra ^b   Fisher, Matthew J ^b   Masters, John J ^b   Goebl, Nancy ^b   Kuklish, Steven L ^b   Morse, Cheryl ^a   Tauscher, Johannes ^b   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Brain; mGlu1 receptors; PET

Indexed keywords

CARBON 11; LSN 2606428; LY 2428703; METABOTROPIC RECEPTOR ANTAGONIST; RADIOLIGAND; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS REACTION; DOSE RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT; RECEPTOR AFFINITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

ALLOSTERIC SITE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON ISOTOPES; CHROMATOGRAPHY, LIQUID; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MALE; MICE; MICE, KNOCKOUT; MODELS, CHEMICAL; POSITRON-EMISSION TOMOGRAPHY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84874106895     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-012-2269-7     Document Type: Article

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