Transcription factor network in embryonic stem cells: Heterogeneity under the stringency

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 2, 2013, Pages 166-170

  Nakai Futatsugi, Yoko ^a   Niwa, Hitoshi ^a  

^a RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

Embryonic stem cell; Metastability; Transcription factor network

Indexed keywords

CD31 ANTIGEN; KRUPPEL LIKE FACTOR 4; LEUKEMIA INHIBITORY FACTOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN HEX; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR REX1; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TBX3; UNCLASSIFIED DRUG; ZINC FINGER AND SCAN DOMAIN CONTAINING 4; ZINC FINGER PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL PLURIPOTENCY; CELL SELF RENEWABILITY; CELLULAR PARAMETERS; DOWN REGULATION; EMBRYONIC STEM CELL; ENZYME INHIBITION; GENE EXPRESSION; GENE REGULATORY NETWORK; GENE SILENCING; INTRACELLULAR SIGNALING; METASTABILITY; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

EMBRYONIC STEM CELLS; MODELS, BIOLOGICAL; PLURIPOTENT STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84874091860     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00958     Document Type: Article

References (31)

1. Evans MJ, Kaufman MH Establishment in culture of pluripotential cells from mouse embryos. Nature, 292, 154-156 (1981).
2. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. U.S.A., 78, 7634-7638 (1981).
3. Smith AG, Hooper ML Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells. Dev. Biol., 121, 1-9 (1987).
4. Smith AG, Heath JK, Donaldson D.D., Wong GG, Moreau J, Stahl M, Rogers D. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature, 336, 688-690 (1988).
5. Williams RL, Hilton DJ, Pease S, Willson T.A., Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola N.A., Gough NM Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature, 336, 684-687 (1988).
6. Niwa H, Burdon T, Chambers I., Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STaT3. Genes Dev., 12, 2048-2060 (1998).
7. Niwa H, Ogawa K, Shimosato D., Adachi K. a parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature, 460, 118-122 (2009).
8. Nichols J, Zevnik B, Anastassiadis K., Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POu transcription factor Oct4. Cell, 95, 379-391 (1998).
9. Yuan H, Corbi N, Basilico C., Dailey L. Developmental-specific activity of the FgF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev., 9, 2635-2645 (1995).
10. Paling NR, Wheadon H, Bone H.K., Welham MJ Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J. Biol. Chem., 279, 48063-48070 (2004).
11. Niwa H, Miyazaki J, Smith AG Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet., 24, 372-376 (2000).
12. Rogers MB, Hosler BA, Gudas LJ Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes. Development, 113, 815-824 (1991).
13. Masui S, Ohtsuka S, Yagi R., Takahashi K, Ko MS, Niwa H. Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells. BMC Dev. Biol., 8, 45 (2008).
14. Toyooka Y, Shimosato D, Murakami K., Takahashi K, Niwa H. Identification and characterization of subpopulations in undifferentiated ES cell culture. Development, 135, 909-918 (2008).
15. Chambers I, Silva J, Colby D., Nichols J, Nijmeijer B, Robertson M., Vrana J, Jones K, Grotewold L., Smith A. Nanog safeguards pluripotency and mediates germline development. Nature, 450, 1230-1234 (2007).
16. Chazaud C, Yamanaka Y, Pawson T., Rossant J. Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the grb2-MaPk pathway. Dev. Cell, 10, 615-624 (2006).
17. Plusa B, Piliszek A, Frankenberg S., Artus J, Hadjantonakis AK distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development, 135, 3081-3091 (2008).
18. Singh AM, Hamazaki T, Hankowski K.E., Terada N. a heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells, 25, 2534-2542 (2007).
19. Hayashi K, Lopes SM, Tang F, Surani MA dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell, 3, 391-401 (2008).
20. Furusawa T, Ohkoshi K, Honda C., Takahashi S, Tokunaga T. Embryonic stem cells expressing both platelet endothelial cell adhesion molecule-1 and stage-specific embryonic antigen-1 differentiate predominantly into epiblast cells in a chimeric embryo. Biol. Reprod., 70, 1452-1457 (2004).
21. canham MA, Sharov AA, Ko M.S., Brickman JM Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol., 8, e1000379 (2010).
22. Falco G, Lee SL, Stanghellini I, Bassey U.C., Hamatani T., Ko MS Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev. Biol., 307, 539-550 (2007).
23. Zalzman M, Falco G, Sharova L.V., Nishiyama A., Thomas M, Lee SL, Stagg C.A., Hoang HG, Yang HT, Indig FE, Wersto R.P., Ko MS. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature, 464, 858-863 (2010).
24. Reynolds N, Latos P, Hynes-Allen A, Loos R., Leaford D, O'Shaughnessy A, Mosaku O, Signolet J., Brennecke P, Kalkan T, Costello I., Humphreys P, Mansfield W, Nakagawa K, Strouboulis J, Behrens A, Bertone P, Hendrich B. NuRd suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell, 10, 583-594 (2012).
25. Kaji K, Caballero IM, MacLeod R, Nichols J., Wilson VA, Hendrich B. The NuRd component Mbd3 is required for pluripotency of embryonic stem cells. Nat. Cell Biol., 8, 285-292 (2006).
26. Kobayashi T, Mizuno H, Imayoshi I., Furusawa C, Shirahige K, kageyama R. The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev., 23, 1870-1875 (2009).
27. Kobayashi T, kageyama R. Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes Cells, 15, 689-698 (2010).
28. Ying QL, Wray J, Nichols J., Batlle-Morera L, Doble B, Woodgett J., Cohen P, Smith A. The ground state of embryonic stem cell self-renewal. Nature, 453, 519-523 (2008).
29. Loh KM, Lim B. a precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell, 8, 363-369 (2011).
30. Martello G, Sugimoto T, Diamanti E., Joshi A, Hannah R, Ohtsuka S., Göttgens B, Niwa H., Smith A. Esrrb is a pivotal target of the gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell, 11, 491-504 (2012).
31. Tang F, Barbacioru C, Bao S., Lee C, Nordman E, Wang X., Lao K, Surani MA Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNa-Seq analysis. Cell Stem Cell, 6, 468-478 (2010).