Interactions between hERG and KCNQ1 α-subunits are mediated by their COOH termini and modulated by cAMP

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 4, 2013, Pages

  Organ Darling, Louise E ^a,b   Vernon, Amanda N ^a   Giovanniello, Jacqueline R ^a   Lu, Yichun ^a   Moshal, Karni ^a   Roder, Karim ^a   Li, Weiyan ^a   Koren, Gideon ^a  

^a BROWN UNIVERSITY   (United States)

^b WELLESLEY COLLEGE   (United States)

Author keywords

Arrhythmia; FRET; Potassium channel; Repolarization reserve

Indexed keywords

CYCLIC AMP; FORSKOLIN; GREEN FLUORESCENT PROTEIN; ISOBUTYLMETHYLXANTHINE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNQ1; PROTEIN VARIANT;

ANIMAL CELL; ARTICLE; BLEACHING; CARBOXY TERMINAL SEQUENCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MALE; MEMBRANE ELECTROPHYSIOLOGY; MEMBRANE PERMEABILITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; QUANTITATIVE ANALYSIS;

1-METHYL-3-ISOBUTYLXANTHINE; ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; FORSKOLIN; HEART; HEK293 CELLS; HUMANS; KCNQ1 POTASSIUM CHANNEL; MALE; PHOSPHODIESTERASE INHIBITORS; RABBITS;

EID: 84874068662     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00385.2012     Document Type: Article

References (37)

1. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97: 175-187, 1999.
2. Akhavan A, Atanasiu R, Noguchi T, Han W, Holder N, Shrier A. Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization. J Cell Sci 118: 2803-2812, 2005.
3. Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, Gong Q, Zhou Z, Ackerman MJ, January CT. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 113: 365-373, 2006.
4. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G. K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384: 78-80, 1996.
5. Biliczki P, Girmatsion Z, Brandes RP, Harenkamp S, Pitard B, Charpentier F, Hebert TE, Hohnloser SH, Baro I, Nattel S, Ehrlich JR. Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction. Heart Rhythm 6: 1792-1801, 2009.
6. Brelidze TI, Carlson AE, Sankaran B, Zagotta WN. Structure of the carboxy-terminal region of a KCNH channel. Nature 481: 530-533, 2012.
7. Brunner M, Peng X, Liu GX, Ren XQ, Ziv O, Choi BR, Mathur R, Hajjiri M, Odening KE, Steinberg E, Folco EJ, Pringa E, Centracchio J, Macharzina RR, Donahay T, Schofield L, Rana N, Kirk M, Mitchell GF, Poppas A, Zehender M, Koren G. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest 118: 2246-2259, 2008.
8. Cui J, Kagan A, Qin D, Mathew J, Melman YF, McDonald TV. Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2. J Biol Chem 276: 17244-17251, 2001.
9. + channel by dual pathways. Curr Biol 10: 671-674, 2000.
10. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803, 1995.
11. Ehrlich JR, Pourrier M, Weerapura M, Ethier N, Marmabachi AM, Hebert TE, Nattel S. KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents. J Biol Chem 279: 1233-1241, 2004.
12. Greeson JN, Organ LE, Pereira FA, Raphael RM. Assessment of prestin self-association using fluorescence resonance energy transfer. Brain Res 1091: 140-150, 2006.
13. Gustina AS, Trudeau MC. hERG potassium channel gating is mediated by N-and C-terminal region interactions. J Gen Physiol 137: 315-325, 2011.
14. Gustina AS, Trudeau MC. A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proc Natl Acad Sci USA 106: 13082-13087, 2009.
15. Han W, Wang Z, Nattel S. Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells. Am J Physiol Heart Circ Physiol 280: H1075-H1080, 2001.
16. Hayashi K, Shuai W, Sakamoto Y, Higashida H, Yamagishi M, Kupershmidt S. Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles. Heart Rhythm 7: 973-980, 2010.
17. Huang N, Lian JF, Huo JH, Liu LY, Ni L, Yang X, Zhou JQ, Li ZF, Song TS, Huang C. The EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells. Cell Biol Int 35: 193-199, 2011.
18. Jost N, Virag L, Bitay M, Takacs J, Lengyel C, Biliczki P, Nagy Z, Bogats G, Lathrop DA, Papp JG, Varro A. Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation 112: 1392-1399, 2005.
19. Karpova TS, Baumann CT, He L, Wu X, Grammer A, Lipsky P, Hager GL, McNally JG. Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser. J Microsc 209: 56-70, 2003.
20. Marques-Carvalho MJ, Morais-Cabral JH. Crystallization and preliminary X-ray crystallographic characterization of a cyclic nucleotide-binding homology domain from the mouse EAG potassium channel. Acta Crystallogr Sect F Struct Biol Cryst Commun 68: 337-339, 2012.
21. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295: 496-499, 2002.
22. + channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains. Biochim Biophys Acta 1783: 1681-1699, 2008.
23. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flugel L, Dorn T, Goedel A, Hohnke C, Hofmann F, Seyfarth M, Sinnecker D, Schomig A, Laugwitz KL. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med 363: 1397-1409, 2010.
24. Patterson GH, Piston DW, Barisas BG. Forster distances between green fluorescent protein pairs. Anal Biochem 284: 438-440, 2000.
25. Piston DW, Kremers GJ. Fluorescent protein FRET: the good, the bad and the ugly. Trends Biochem Sci 32: 407-414, 2007.
26. Potet F, Scott JD, Mohammad-Panah R, Escande D, Baro I. AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am J Physiol Heart Circ Physiol 280: H2038-H2045, 2001.
27. Ren XQ, Liu GX, Organ-Darling LE, Zheng R, Roder K, Jindal HK, Centracchio J, McDonald TV, Koren G. Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines. Am J Physiol Heart Circ Physiol 299: H1525-H1534, 2010.
28. Roden DM. Taking the "idio" out of "idiosyncratic": predicting torsades de pointes. Pacing Clin Electrophysiol 21: 1029-1034, 1998.
29. Roden DM, Yang T. Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve. Circulation 112: 1376-1378, 2005.
30. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384: 80-83, 1996.
31. Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81: 299-307, 1995.
32. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96: 195-215, 1990.
33. Trudeau MC, Warmke JW, Ganetzky B, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269: 92-95, 1995.
34. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, Van-Raay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12: 17-23, 1996.
35. Warmke JW, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 91: 3438-3442, 1994.
36. Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296: 913-916, 2002.
37. + currents in the heart. Am J Physiol Heart Circ Physiol 285: H1641-H1649, 2003.