Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: A new attractor for peripheral vascular disease?

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 4, 2013, Pages

  Butcher, Joshua T ^a   Goodwill, Adam G ^a   Stanley, Shyla C ^a   Frisbee, Jefferson C ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Blood flow heterogeneity; vascular dysfunction; Microcirculation; Models of peripheral vascular disease; Rodent models of obesity; Skeletal muscle blood flow regulation

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; PHENTOLAMINE; TEMPOL; THROMBOXANE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; CONTROLLED STUDY; CREMASTER MUSCLE; ENZYME ACTIVITY; ISCHEMIA; MALE; METABOLIC SYNDROME X; MICROCIRCULATION; MUSCLE FUNCTION; NONHUMAN; OXIDATIVE STRESS; PERFUSION; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TREATMENT OUTCOME;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIOXIDANTS; ARTERIOLES; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; HUMANS; HYDRAZINES; MALE; METABOLIC SYNDROME X; MICROVESSELS; MUSCLE, SKELETAL; OBESITY; OXIDATIVE STRESS; PERIPHERAL VASCULAR DISEASES; PHENTOLAMINE; RATS; RATS, ZUCKER; SPIN LABELS;

EID: 84874054716     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00805.2012     Document Type: Article

References (59)

1. Ait-Oufella H, Taleb S, Mallat Z, Tedgui A. Recent advances on the role of cytokines in atherosclerosis. Arterioscler Thromb Vasc Biol 31: 969-979, 2011.
2. Bagher P, Segal SS. The mouse cremaster muscle preparation for intravital imaging of the microcirculation. J Vis Exp 52: 2874, 2011.
3. Bagher P, Segal SS. Regulation of blood flow in the microcirculation: role of conducted vasodilation. Acta Physiol (Oxf) 202: 271-284, 2011.
4. Baker M, Wayland H. On-line volume-flow rates and velocity profile measurements for blood in microvessels. Microvasc Res 7: 131-143, 1974.
5. Baskurt OK, Yalcin O, Gungor F, Meiselman HJ. Hemorheological parameters as determinants of myocardial tissue hematocrit values. Clin Hemorheol Microcirc 35: 45-50, 2006.
6. Bassingthwaighte JB, Liebovitch LS, West BJ. Intraorgan flow heterogeneities. In: Fractal Physiology. New York: Oxford University Press, 1994. p. 236-262.
7. Behringer EJ, Segal SS. Spreading the signal for vasodilatation: implications for skeletal muscle blood flow control and the effects of aging. J Physiol 15: 6277-6284, 2012.
8. Bos C, Hoofd L, Oostendorp T. Mathematical model of erythrocytes as point-like sources. Math Biosci 125: 165-189, 1995.
9. Businaro R, Tagliani A, Buttari B, Profumo E, Ippoliti F, Di Cristofano C, Capoano R, Salvati B, Riganò R. Cellular and molecular players in the atherosclerotic plaque progression. Ann N Y Acad Sci 1262: 134-141, 2012.
10. Calbet JA, Joyner MJ. Disparity in regional and systemic circulatory capacities: do they affect the regulation of the circulation? Acta Physiol (Oxf) 199: 393-406, 2010.
11. Carlson SH, Shelton J, White CR, Wyss JM. Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats. Hypertension 35: 403-408, 2000.
12. Chandra S, Singh V, Nehra M, Agarwal D, Singh N. ST-segment elevation in non-atherosclerotic coronaries: a brief overview. Intern Emerg Med 6: 129-139, 2011.
13. Clifford PS, Hellsten Y. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97: 393-403, 2004.
14. Cokelet GR. Rheology and hemodynamics. Annu Rev Physiol 42: 311-324, 1980.
15. Cokelet GR. Experimental determination of the average hematocrit of blood flowing in a vessel. Microvasc Res 7: 382-384, 1974.
16. Colantuoni A, Bertuglia S, Intaglieeta M. Effects of anesthesia on the spontaneous activity of the microvasculature. Int J Microcirc Clin Exp 3: 13-28, 1984.
17. Davis MJ. Perspective: physiological role(s) of the vascular myogenic response. Microcirculation 19: 99-114, 2012.
18. Davis MJ. Determination of volumetric flow in capillary tubes using an optical Doppler velocimeter. Microvasc Res 34: 223-230, 1987.
19. Dean SM. Atypical ischemic lower extremity ulcerations: a differential diagnosis. Vasc Med 13: 47-54, 2008.
20. Demer L, Tintut Y. The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification. Circ Res 108: 1482-1493, 2011.
21. Diep HK, Vigmond EJ, Segal SS, Welsh DG. Defining electrical communication in skeletal muscle resistance arteries: a computational approach. J Physiol 568: 267-281, 2005.
22. Ellsworth ML, Sprague RS. Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP. J Physiol 590: 4985-4991, 2012.
23. Fenton BM, Carr RT, Cokelet GR. Nonuniform red cell distribution in 20 to 100 micrometers bifurcations. Microvasc Res 29: 103-126, 1985.
24. Frisbee JC, Wu F, Goodwill AG, Butcher JT, Beard DA. Spatial heterogeneity in skeletal muscle microvascular blood flow distribution is increased in the metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 301: R975-R986, 2011.
25. Frisbee JC, Goodwill AG, Butcher JT, Olfert IM. Divergence between arterial perfusion and fatigue resistance in skeletal muscle in the metabolic syndrome. Exp Physiol 96: 369-383, 2011.
26. Frisbee JC, Sylvester FA, Lombard JH. Contribution of extrinsic factors and intrinsic vascular alterations to reduced arteriolar reactivity with high-salt diet and hypertension. Microcirculation 7: 281-289, 2000.
27. Fuster JJ, Castillo AI, Zaragoza C, Ibáñez B, Andrés V. Animal models of atherosclerosis. Prog Mol Biol Transl Sci 105: 1-23, 2012.
28. Gaehtgens P. Distribution of flow and red cell flux in the microcirculation. Scand J Clin Lab Invest Suppl 156: 83-87, 1981.
29. Goldman D, Fraser GM, Ellis CG, Sprague RS, Ellsworth ML, Stephenson AH. Toward a multiscale description of microvascular flow regulation: O2-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks. Front Physiol 3: 246, 2012.
30. Greenwald SE. Ageing of the conduit arteries. J Pathol 211: 157-172, 2007.
31. Hill SF, Sheppard MN. Non-atherosclerotic coronary artery disease associated with sudden cardiac death. Heart 96: 1119-1125, 2010.
32. Kasiske BL, Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19: I110-I115, 1992.
33. Kiani MF, Pries AR, Hsu LL, Sarelius IH, Cokelet GR. Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms. Am J Physiol Heart Circ Physiol 266: H1822-H1828, 1994.
34. Lipowsky HH. Microvascular rheology and hemodynamics. Microcirculation 12: 5-15, 2005.
35. Lombard JH, Frisbee JC, Greene AS, Hudetz AG, Roman RJ, Tonellato PJ. Microvascular flow and tissue PO2 in skeletal muscle of chronic reduced renal mass hypertensive rats. Am J Physiol Heart Circ Physiol 279: H2295-H2302, 2000.
36. Mandelbrot BB, Fractal attractors, fractal (chaotic=) evolutions. In: The Fractal Geometry of Nature. New York: W. H. Freeman and Company, 1983, p. 193-199.
37. Mathé D. Dyslipidemia and diabetes: animal models. Diabete Metab 21: 106-111, 1995.
38. Menolascina F, Siciliano V, di Bernardo D. Engineering and control of biological systems: a new way to tackle complex diseases FEBS Lett 586: 2122-2128, 2012.
39. Meru AV, Mittra S, Thyagarajan B, Chugh A. Intermittent claudication: an overview. Atherosclerosis. 187: 221-237, 2006.
40. Pamidimukkala J, Jandhyala BS. Evaluation of hemodynamics, vascular reactivity and baroreceptor compensation in the insulin resistance Zucker obese rats. Clin Exp Hypertens 18: 1089-1104, 1996.
41. Park KW, Dai HB, Lowenstein E, Sellke FW. Effect of sevoflurane and desflurane on the myogenic constriction and flow-induced dilation in rat coronary arterioles. Anesthesiology 90: 1422-1427, 1999.
42. Pries AR, Secomb TW, Gaehtgens P, Gross JF. Blood flow in microvascular networks. Experiments and simulation. Circ Res 67: 826-834, 1990.
43. Pries AR, Ley K, Gaehtgens P. Generalization of the Fahraeus principle for microvessel networks. Am J Physiol Heart Circ Physiol 251: H1324-H1332, 1986.
44. Ren J. Leptin and hyperleptinemia-from friend to foe for cardiovascular function. J Endocrinol 181: 1-10, 2004.
45. Rioufol G, Finet G. Non-atherosclerotic mild anterior myocardial ischaemia. Arch Cardiovasc Dis 103: 135-136, 2010.
46. Rollie S, Mangold M, Sundmacher K. Designing biological systems: systems engineering meets synthetic biology. Chem Engineer Sci 69: 1-29, 2012.
47. Schreihofer AM, Mandel DA, Mobley SC, Stepp DW. Impairment of sympathetic baroreceptor reflexes in obese Zucker rats. Am J Physiol Heart Circ Physiol 293: H2543-H2549, 2007.
48. Seagard JL, Bosnjak ZJ, Hopp FA Jr, Kotrly KJ, Ebert TJ, Kampine JP. Cardiovascular effects of general anesthesia. In: Effects of Anesthesia, Eds: Covino BR, Fozzard HA, Rehder K, Strichartz H. Baltimore, MD: Waverly Press, 1985, p. 149-170.
49. Segal SS. Regulation of blood flow in the microcirculation. Microcirculation 12: 33-45, 2005.
50. Sprague RS, Ellsworth ML. Erythrocyte-derived ATP and perfusion distribution: role of intracellular and intercellular communication. Microcirculation 19: 430-439, 2012.
51. Sprague RS, Bowles EA, Achilleus D, Stephenson AH, Ellis CG, Ellsworth ML. A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control. Am J Physiol Heart Circ Physiol 301: H2466-H2472, 2011.
52. Stainsby WN, Snyder B, Welch HG. A pictographic essay on blood and tissue oxygen transport. Med Sci Sports Exerc 20: 213-221, 1988.
53. Tanofsky-Kraff M, Yanovski SZ. Eating disorder or disordered eating? Non-normative eating patterns in obese individuals. Obes Res 12: 1361-1366, 2004.
54. Tigno XT, Hansen BC, Nawang S, Shamekh R, Albano AM. Vasomotion becomes less random as diabetes progresses in monkeys. Microcirculation 18: 429-439, 2011.
55. Tran CH, Vigmond EJ, Plane F, Welsh DG. Mechanistic basis of differential conduction in skeletal muscle arteries. J Physiol 587: 1301-1318, 2009.
56. Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab 21: 345-352, 2010.
57. van der Greef J, Hankemeier T, McBurney RN. Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics 7: 1087-1094, 2006.
58. Wagner CD, Nafz B, Persson PB. Chaos in blood pressure control. Cardiovasc Res 31: 380-387, 1996.
59. Wu F, Beard DA, Frisbee JC. Computational analyses of intravascular tracer washout reveal altered capillary-level flow distributions in obese Zucker rats. J Physiol 589: 4527-4543, 2011.