Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1

Food Chemistry

Volumn 138, Issue 4, 2013, Pages 2140-2145

  Takeda, Junko ^a   Park, Ha Young ^a   Kunitake, Yuri ^a   Yoshiura, Keiko ^a   Matsui, Toshiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

AMPK; PEPT1; Peptide transport; Theaflavin

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE; AMPK; PEPT1; PEPTIDE TRANSPORT; PEPTIDE TRANSPORTER; THEAFLAVINS; TRANSPORT EXPERIMENTS; WESTERN-BLOT ANALYSIS;

CELLS; MONOLAYERS;

PEPTIDES;

GLYCYLSARCOSINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOLEUCINE; PEPTIDE TRANSPORTER 1; PHENYLALANINE; PROTEIN SERINE THREONINE KINASE INHIBITOR; THEAFLAVIN; THEAFLAVIN 3,3' DIGALLATE; THEAFLAVINE 3 GALLATE; THEAFLAVINE 3' GALLATE; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; ATTENUATION; CELL STRAIN CACO 2; CONTROLLED STUDY; DOWN REGULATION; INTESTINE ABSORPTION; MONOLAYER CULTURE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; BIFLAVONOIDS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CATECHIN; DIMERIZATION; DOWN-REGULATION; HUMANS; INTESTINE, SMALL; PEPTIDES; SYMPORTERS;

CAMELLIA SINENSIS;

EID: 84874016283     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.12.026     Document Type: Article

References (30)

1. S.A. Adibi Regulation of expression of the intestinal oligopeptide transporter (pept-1) in health and disease American Journal of Physiology, Gastrointestinal and Liver Physiology 285 2003 G779 788
2. i American Journal of Physiology, Gastrointestinal and Liver Physiology 267 1994 G465 475
3. + co-transport system in the caco-2 human colon carcinoma cell line The Biochemical Journal 299 1994 253 260
4. P.D. Collier, T. Bryce, R. Mallows, P.E. Thomas, D.J. Frost, and O. Korver The theaflavins of black tea Tetrahedron 29 1973 125 142
5. G. Da Violante, N. Zerrouk, I. Richard, G. Provot, J.C. Chaumeil, and P. Arnaud Evaluation of the cytotoxicity effect of dimethyl sulfoxide (DMSO) on Caco2/TC7 colon tumor cell cultures Biological & Pharmaceutical Bulletin 25 2002 1600 1603
6. Y.J. Fei, Y. Kanai, S. Nussberger, V. Ganapathy, F.H. Leibach, and M.F. Romero Expression cloning of a mammalian proton-coupled oligopeptide transporter Nature 368 1994 563 566
7. D.G. Hardie AMPK: A key regulator of energy balance in the single cell and the whole organism International Journal of Obesity 32 Suppl 4 2008 S7 12
8. Y. Hata, M. Yamamoto, M. Ohni, K. Nakajima, Y. Nakamura, and T. Takano A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects The American Journal of Clinical Nutrition 64 1996 767 771
9. T. Kawasaki, E. Seki, K. Osajima, M. Yoshida, K. Asada, and T. Matsui Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects Journal of Human Hypertension 14 2000 519 523
10. J. Kovacs-Nolan, H. Zhang, M. Ibuki, T. Nakamori, K. Yoshiura, and P.V. Turner The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation Biochimica Biophyica Acta-General Subjects 1820 2012 1753 1763
11. O. Kwon, P. Eck, S. Chen, C.P. Corpe, J.H. Lee, and M. Kruhlak Inhibition of the intestinal glucose transporter GLUT2 by flavonoids FASEB Journal 21 2007 366 377
12. +/peptide cotransporter. cloning, functional expression, and chromosomal localization The Journal of Biological Chemistry 270 1995 6456 6463
13. T. Matsui, and K. Matsumoto Antihypertensive peptides from natural resources M.T.H. Khan, A. Ather, Advances in Phytomedicine 2006 Elsevier Netherlands 255 271
14. T. Matsui, M. Sato, M. Tanaka, Y. Yamada, S. Watanabe, and Y. Fujimoto Vasodilating dipeptide Trp-His can prevent atherosclerosis in apo E-deficient mice The British Journal of Nutrition 103 2010 309 313
15. T. Matsui, K. Tamaya, E. Seki, K. Osajima, K. Matsumoto, and T. Kawasaki Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system Clinical and Experimental Pharmacology & Physiology 29 2002 204 208
16. T. Matsui, T. Tanaka, S. Tamura, A. Toshima, K. Tamaya, and Y. Miyata Alpha-glucosidase inhibitory profile of catechins and theaflavins Journal of Agricultural and Food Chemistry 55 2007 99 105
17. T.P. Mulder, C.J. van Platerink, P.J. Wijnand Schuyl, and J.M. van Amelsvoort Analysis of theaflavins in biological fluids using liquid chromatography-electrospray mass spectrometry Journal of Chromatography B, Biomedical Sciences and applications 760 2001 271 279
18. S. Nagaoka, Y. Futamura, K. Miwa, T. Awano, K. Yamauchi, and Y. Kanamaru Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin Biochemical and Biophysical Research Communications 281 2001 11-7
19. 13C stable isotope labeling liquid chromatography-multiple reaction monitoring-tandem mass spectrometry method for determining intact absorption of bioactive dipeptides in rats Analytical Biochemistry 414 2011 109 116
20. L. Peng, Z.R. Li, R.S. Green, I.R. Holzman, and J. Lin Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in caco-2 cell monolayers The Journal of Nutrition 139 2009 1619 1625
21. M. Pieri, H.C. Christian, R.J. Wilkins, C.A. Boyd, and D. Meredith The apical (hPepT1) and basolateral peptide transport systems of caco-2 cells are regulated by AMP-activated protein kinase American Journal of Physiology, Gastrointestinal and Liver Physiology 299 2010 G136 143
22. J. Qiu, Y. Kitamura, Y. Miyata, S. Tamaru, K. Tanaka, and T. Tanaka Transepithelial transport of theasinensins through caco-2 cell monolayers and their absorption in Sprague-Dawley rats after oral administration Journal of Agricultural and Food Chemistry 60 2012 8036 8043
23. S. Sang, J.D. Lambert, S. Tian, J. Hong, Z. Hou, and J.H. Ryu Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities Bioorganic & Medicinal Chemistry 12 2004 459 467
24. +-coupled glucose carrier SGLT1 by AMP-activated protein kinase Molecular Membrane Biology 27 2010 137 144
25. T. Suzuki, and H. Hara Role of flavonoids in intestinal tight junction regulation The Journal of Nutritional Biochemistry 22 2011 401 408
26. T. Tanaka, K. Inoue, Y. Betsumiya, C. Mine, and I. Kouno Two types of oxidative dimerization of the black tea polyphenol theaflavin Journal of Agricultural and Food Chemistry 49 2001 5785 5789
27. T. Ueno, M. Tanaka, T. Matsui, and K. Matsumoto Determination of antihypertensive small peptides, Val-Tyr and Ile-Val-Tyr, by fluorometric high-performance liquid chromatography combined with a double heart-cut column-switching technique Analytical Sciences 21 2005 997 1000
28. A. Ukil, S. Maity, and P.K. Das Protection from experimental colitis by theaflavin-3,3′-digallate correlates with inhibition of IKK and NF-kappaB activation British Journal of Pharmacology 149 2006 121 131
29. T.D. Way, H.H. Lee, M.C. Kao, and J.K. Lin Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression European Journal of Cancer 40 2004 2165 2174
30. X.L. Zhu, K. Watanabe, K. Shiraishi, T. Ueki, Y. Noda, and T. Matsui Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers Peptides 29 2008 338 344