Inhibition of lipopolysaccharide-induced nitric oxide and prostaglandin E2 production by chloroform fraction of Cudrania tricuspidata in RAW 264.7 macrophages

BMC Complementary and Alternative Medicine

Volumn 12, Issue , 2012, Pages

  Yang, Gabsik ^a   Lee, Kyungjin ^a   Lee, Mihwa ^a   Ham, Inhye ^a   Choi, Ho Young ^a  

^a Kyung Hee University   (South Korea)

Author keywords

CTC, Lipopolysaccharide; Cudrania tricuspidata; Lipopolysaccharide CHCl3 partitioned methanol extract of Cudrania tricuspidata; LPS, prostaglandin E2; Nitric oxide; NO; PGE2, nitric oxide; Prostaglandin E2

Indexed keywords

CHLOROFORM; CUDRANIA TRICUSPIDATA EXTRACT; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CUDRANIA TRICUSPIDATA; FRACTIONATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TREE;

EID: 84874005167     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-12-250     Document Type: Article

References (19)

1. Lawrence T, Willoughby DA, Gilroy DW. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2002, 2(10):787-795. 10.1038/nri915, 12360216.
2. Kaplanski G, et al. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol 2003, 24(1):25-29. 10.1016/S1471-4906(02)00013-3, 12495721.
3. Medzhitov R, Janeway CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91(3):295-298. 10.1016/S0092-8674(00)80412-2, 9363937.
4. Grahames CB, et al. Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes. Br J Pharmacol 1999, 127(8):1915-1921. 10.1038/sj.bjp.0702732, 1566177, 10482924.
5. Mehta VB, Hart J, Wewers MD. ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J Biol Chem 2001, 276(6):3820-3826. 10.1074/jbc.M006814200, 11056157.
6. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 1990, 8:253-278. 10.1146/annurev.iy.08.040190.001345, 2188664.
7. Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006, 290(4):L622-L645. 10.1152/ajplung.00477.2005, 16531564.
8. Posadas I, et al. Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation. Naunyn Schmiedebergs Arch Pharmacol 2000, 361(1):98-106. 10.1007/s002109900150, 10651154.
9. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991, 43(2):109-142.
10. Yun HY, Dawson VL, Dawson TM. Neurobiology of nitric oxide. Crit Rev Neurobiol 1996, 10(3-4):291-316.
11. Hinz B, Brune K. [Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances]. Wien Klin Wochenschr 1999, 111(3):103-112.
12. Lee IK, et al. Cytotoxic benzyl dihydroflavonols from Cudrania tricuspidata. Phytochemistry 1996, 41(1):213-216. 10.1016/0031-9422(95)00609-5, 8588866.
13. Cho EJ, et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. Am J Chin Med 2003, 31(6):907-917. 10.1142/S0192415X03001648, 14992543.
14. Kang DG, et al. Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension. Life Sci 2002, 70(22):2599-2609. 10.1016/S0024-3205(02)01547-3, 12269387.
15. Chang SH, et al. Anti-inflammatory action of Cudrania tricuspidata on spleen cell and T lymphocyte proliferation. J Pharm Pharmacol 2008, 60(9):1221-1226. 10.1211/jpp.60.9.0015, 18718127.
16. Seo WG, et al. Ethyl acetate extract of the stem bark of Cudrania tricuspidata induces apoptosis in human leukemia HL-60 cells. Am J Chin Med 2001, 29(2):313-320. 10.1142/S0192415X01000332, 11527073.
17. Janeway CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002, 20:197-216. 10.1146/annurev.immunol.20.083001.084359, 11861602.
18. Holtmann H, Resch K. Cytokines. Naturwissenschaften 1995, 82(4):178-187.
19. Murray JS, et al. Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. Eur J Immunol 1992, 22(2):559-565. 10.1002/eji.1830220239, 1347015.