Degradation Products of hCG, Hyperglycosylated hCG, and Free β-Subunit

Human Chorionic Gonadotropin (hCG)

Volumn , Issue , 2010, Pages 109-118

  Cole, Laurence A ^a  

^a USA hCG Reference Service   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84874000484     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-384907-6.00009-8     Document Type: Chapter

References (22)

1. Cole LA Human chorionic gonadotropin and associated molecules. Expert Rev Mol Diag 2009, 9:51-73.
2. Nisula BC, Blithe DL, Akar A, Lefort G, Wehmann RE Metabolic fate of human chorionic gonadotropin. J Steroid Biochem 1989, 33:733-737.
3. Strickland TW, Puett D The kinetic and equilibrium parameters of subunit association and dissociation. J Biol Chem 1982, 257:2954-2960.
4. Rosa C, Amr S, Birken S, Wehmann R, Nisula B Effects of desialylation on human chorionic gonadotropin on its metabolic clearance rate in humans. J Clin Endocrinol Metab 1984, 59:1215-1219.
5. Veldhuis JD, Fraioli F, Rogol AD, Dufau ML Metabolic clearance of biologically active luteinizing hormone in man. J Clin Invest 1986, 77:1122-1128.
6. Lefort GP, Stolk JM, Nisula BC Evidence that desialylation and uptake by hepatic receptors for galactose-terminated glycoproteins are immaterial to the metabolism of human choriogonadotropin in the rat. Endocrinol 1984, 115:1551-1557.
7. Van Hall EV, Vaitukaitis JL, Ross GT, Hickman JW, Ashwell G Effects of progressive desialylation on the rate of disappearance of immunoreactive hCG from plasma in rats. Endocrinol 1971, 89:11-15.
8. Wide L, Hobson B Some qualitative differences of hCG in serum from early and late pregnancies and trophoblastic diseases. Acta Endocrinol 1987, 116:465-472.
9. Wehmann RE, Nisula BC Metabolic clearance rates of the subunits of human chorionic gonadotropin. J Clin Endocrinol Metab 1979, 48:753-759.
10. Wemann RE, Nisula BC Metabolic and renal clearance rates of purified human chorionic gonadotropin. J Clin Invest 1981, 68:184-194.
11. Cole LA, Karadana A, Park S-Y, Braunstein GD The deactivation of hCG by nicking and dissociation. J Clin Endocrinol Metab 1993, 76:704-715.
12. Karadana A, Cole LA Human chorionic gonadotropin β-subunit nicking enzymes in pregnancy and cancer patient serum. J Clin Endocrinol Metab 1994, 79:761-767.
13. Cole LA, Shahabi S, Butler S, Mitchell H, Newlands ES, Behrman HR, et al. Utility of commonly used commercial hCG immunoassays in the diagnosis and management of trophoblastic diseases. Clin Chem 2001, 47:308-915.
14. Kardana A, Elliott ME, Gawinowicz MA, Birken S, Cole LA The heterogeneity of hCG: I. Characterization of peptide variations in 13 individual preparations of hCG. Endocrinol 1991, 129:1541-1550.
15. Elliott MM, Kardana A, Lustbader JW, Cole LA Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 1997, 7:15-32.
16. Cole LA, Kardana A, Andrade-Gordon P, Gawinowicz MA, Morris JC, Bergert ER, et al. The heterogeneity of hCG: III. The occurrence, biological and immunological activities of nicked hCG. Endocrinol 1991, 129:1559-1567.
17. Norman RJ, Buchholtz MW, Somogyl AA, Amato F hCG-β core fragment is a metabolite of hCG: evidence from the infusion of recombinant hCG. J Endocrinol 2000, 164:299-305.
18. Korhonen J, Alfhan H, Ylostalo P, Veldhuis J, Stenmam U-H Disappearance of human chorionic gonadotropin and its α- and β-subunits after term pregnancy. Clin Chem 1997, 43:2155-2163.
19. Aral K, Gunrkan Zorlu C, Gokman O Plasma human chorionic gonadotropin levels after induced abortion. Adv Contracept 1996, 12:11-14.
20. Lajos L, Pali K Choriongonadotropin clearance tests. Endokrinologie 1951, 28:129-134.
21. Kamrava MM, Taymor ML, Berger MJ, Thompson IE, Seibel MM Disappearance of human chorionic gonadotropin following removal of ectopic pregnancy. Obstet Gynecol 1983, 62:486-488.
22. Cassels JW, Mann K, Blithe DL, Nisula BC, Wehmann RE Reduced metabolic clearance of acidic variants of human choriogonadotropin from patients with testicular cancer. Cancer 1989, 64:2313-2318.