hCGβ core fragment is a metabolite of hCG: Evidence from infusion of recombinant hCG

Journal of Endocrinology

Volumn 164, Issue 3, 2000, Pages 299-305

  Norman, R J ^a,b   Buchholz, M M ^a   Somogyi, A A ^c   Amato, F ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b QUEEN ELIZABETH HOSPITAL   (Australia)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; RECOMBINANT HORMONE; CHORIONIC GONADOTROPIN BETA SUBUNIT; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; URINARY GONADOTROPIN FRAGMENT;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HALF LIFE TIME; HORMONE METABOLISM; HORMONE URINE LEVEL; HUMAN; HUMAN EXPERIMENT; KIDNEY CLEARANCE; NORMAL HUMAN; PRIORITY JOURNAL; ADOLESCENT; BLOOD; CLINICAL TRIAL; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; METABOLISM; URINE;

ADOLESCENT; ADULT; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; FEMALE; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; METABOLIC CLEARANCE RATE; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS;

EID: 0033621841     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1640299     Document Type: Article

References (24)

1. Amr S, Wehmann RE, Birken S, Canfield RE & Nisula BC 1983 Characterization of a carboxyterminal peptide fragment of the human choriogonadotropin β-subunit excreted in the urine of a woman with choriocarcinoma. Journal of Clinical Investigation 71 329-339.
2. Birken S, Armstrong EG, Gawinowicz-Kolks MA, Cole LA, Agosto GM, Krichevsky A, Vaitukaitis JL & Canfield RE 1988 Structure of the human chorionic gonadotropin β-subunit fragment from pregnancy urine. Endocrinology 123 572-583.
3. Birken S, Gawinowicz MA, Kardana A & Cole LA 1991 The heterogeneity of human chorionic gonadotropin (hCG). II. Characteristics and origin of nicks in hCG reference standards. Endocrinology 129 1551-1558.
4. Blithe DL, Akar AH, Wehmann RE & NiSula BC 1988 Purification of β-core fragment from pregnancy urine and demonstration that its carbohydrate moieties differ from those of native human chorionic gonadotropin. Endocrinology 122 173-180.
5. Cole LA 1997 Immunoassay of human chorionic gonadotropin, its free subunits and metabolites. Clinical Chemistry 43 2233-2243.
6. Cole LA & Birken S 1988 Origin and occurrence of human chorionic gonadotropin β-subunit core fragment. Molecular Endocrinology 2 825-830.
7. Cole LA, Park S-Y & Braunstein GD 1993 The deactivation of hCG by nicking and dissociation. Journal of Clinical Endocrinology and Metabolism 76 704-710.
8. Kardana A, Taylor ME, Southall PJ, Boxer GM, Rowan AJ & Bagshaw KD 1988 Urinary gonadotropin peptide isolation and purification, and its immunohistochemical distribution in normal and neoplastic tissues. British Journal of Cancer 58 282-286.
9. Kardana A, Elliott MM, Gawinowicz MA Birken S & Cole LA 1991 The heterogeneity of human chorionic gonadotropin (hCG). I. Characteristics of peptide heterogeneity in 13 individual preparations of hCG. Endocrinology 129 1541-1550.
10. Kato Y & Braunstein GD 1988 β core fragment is a major form of immunoreactive urinary chorionic gonadotropin in human pregnancy. Journal of Clinical Endocrinology and Metabolism 66 1197-1201.
11. Korhonen J, Alfthan H, Ylöstalo P, Veldhuis J & Stenman U-H 1997 Disappearance of human chorionic gonadotropin and its α-and β-subunit after term pregnancy. Clinical Chemistry 43 2155-2163.
12. Krichevsky A, Armstrong EG, Schlatterer J, Birken S, O'Connor J, Bikel K, Silverberg S, Lustbader JW & Canfield RE 1988 Preparation and characterization of antibodies to the urinary fragment of human chorionic gonadotropin β-subunit. Endocrinology 123 584-593.
13. Lefort GP, Stolk JM & Nisula BC 1986 Renal metabolism of the beta-subunit of human choriogonadotropin in the rat. Endocrinology 119 924-931.
14. de Medeiros SF, Amato F, Matthews CD & Norman RJ 1992a Comparison of specific immunoassays for detection of the β-core human chorionic gonadotrophin fragment in body fluids. Journal of Endocrinology 135 161-174.
15. de Medeiros SF, Amato F, Matthews CD & Norman RJ 1992b Urinary concentrations of β-core fragment of hCG throughout pregnancy. Obstetrics and Gynecology 80 223-228.
16. Midgley AR Jr & Jaffe RB 1968 Regulation of human gonadotropins: II. Disappearance of human chorionic gonadotropin following delivery. Journal of Clinical Endocrinology and Metabolism 28 1712-1718.
17. Puisieux A, Bellet D, Troalen F, Razafindratsita A, Lhomme C & Bidart JM 1990 Occurrence of fragmentation of free and combined forms of the beta-subunit of human chorionic gonadotropin. Endocrinology 126 687-694.
18. Rizkallah T, Gurpide E & Vande Wiel RL 1969 Metabolism of hCG in man. Journal of Clinical Endocrinology and Metabolism 29 92-100.
19. Udagawa A, Okamoto T, Nomura S, Matsuo K, Suzuki H & Mizutani S 1998 Human chorionic gonadotropin beta-core fragment is present in the human placenta. Molecular and Cellular Endocrinology 139 171-178.
20. Wehmann RE & Nisula BC 1981 Metabolic and renal clearance rates of purified human chorionic gonadotropin. Journal of Clinical Investigation 68 184-194.
21. Wehmann RE, Blithe DL, Flack MR & Nisula BC 1989 Metabolic clearance rate and urinary clearance of purified β-core. Journal of Clinical Endocrinology and Metabolism 69 510-517.
22. Wehmann RE, Blithe DL, Akar AH & Nisula BC 1990 Disparity between β-core levels in pregnancy urine and serum: implications for the origin of urinary β-core. Journal of Clinical Endocrinology and Metabolism 70 371-378.
23. Wide L, Johannisson E & Tillinger KG 1968 Metabolic clearance rate of human chorionic gonadotrophin administered to non pregnant women. Acta Endocrinologica 59 579-594.
24. Yen SSC, Llerena O, Little B & Pearson OH 1968 Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man. Journal of Clinical Endocrinology and Metabolism 28 1763-1767.