메뉴 건너뛰기




Volumn 33, Issue 2, 2013, Pages 401-411

Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model

Author keywords

Calcification; Chondrocytes; Degenerative joint diseases; Hypertrophy; Osteoarthritis

Indexed keywords

ASCORBIC ACID; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BONE MORPHOGENETIC PROTEIN 2; GLYCEROL 2 PHOSPHATE; LIOTHYRONINE; ONCOSTATIN M; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

EID: 84874000449     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2368-6     Document Type: Article
Times cited : (23)

References (44)
  • 1
    • 66149180583 scopus 로고    scopus 로고
    • Developments in the scientific understanding of osteoarthritis
    • 19519925 10.1186/ar2655
    • Abramson S, Attur M (2009) Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther 11:227-235
    • (2009) Arthritis Res Ther , vol.11 , pp. 227-235
    • Abramson, S.1    Attur, M.2
  • 2
    • 31544452086 scopus 로고    scopus 로고
    • Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    • Hayami T, Pickarski M, Zhuo Y et al (2006) Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 38:234-243
    • (2006) Bone , vol.38 , pp. 234-243
    • Hayami, T.1    Pickarski, M.2    Zhuo, Y.3
  • 3
    • 35348964525 scopus 로고    scopus 로고
    • Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage
    • 10.1186/ar2013
    • Davidson R, Waters J, Kevorkian L et al (2006) Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Res Ther 8:124-133
    • (2006) Arthritis Res Ther , vol.8 , pp. 124-133
    • Davidson, R.1    Waters, J.2    Kevorkian, L.3
  • 4
    • 77949907278 scopus 로고    scopus 로고
    • Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?
    • Bay-Jensen AC, Hoegh-Madsen S, Dam E et al (2010) Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis? Rheumatol Int 30:435-442
    • (2010) Rheumatol Int , vol.30 , pp. 435-442
    • Bay-Jensen, A.C.1    Hoegh-Madsen, S.2    Dam, E.3
  • 5
    • 29844453023 scopus 로고    scopus 로고
    • Osteoarthritis cartilage histopathology: Grading and staging
    • Pritzker KPH, Gay S, Jimenez SA et al (2006) Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartil 14:13-29
    • (2006) Osteoarthritis Cartil , vol.14 , pp. 13-29
    • Kph, P.1    Gay, S.2    Jimenez, S.A.3
  • 6
    • 0034946863 scopus 로고    scopus 로고
    • Splice variants VEGF121 and VEGF165 of the angiogenic peptide vascular endothelial cell growth factor are expressed in the synovial tissue of patients with rheumatoid arthritis
    • Pufe T, Petersen W, Tillmann B et al (2001) Splice variants VEGF121 and VEGF165 of the angiogenic peptide vascular endothelial cell growth factor are expressed in the synovial tissue of patients with rheumatoid arthritis. J Rheumatol 28:1482-1485
    • (2001) J Rheumatol , vol.28 , pp. 1482-1485
    • Pufe, T.1    Petersen, W.2    Tillmann, B.3
  • 7
    • 42949166679 scopus 로고    scopus 로고
    • Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models
    • Hiroshi K (2008) Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models. Mol Cells 25:1-6
    • (2008) Mol Cells , vol.25 , pp. 1-6
    • Hiroshi, K.1
  • 8
    • 77953408273 scopus 로고    scopus 로고
    • Cellular senescence is a common characteristic shared by preneoplastic and osteo-arthritic tissue
    • Jean-Marc B, Didier P, Farida D et al (2010) Cellular senescence is a common characteristic shared by preneoplastic and osteo-arthritic tissue. Open Rheumatol J 4:10-14
    • (2010) Open Rheumatol J , vol.4 , pp. 10-14
    • Jean-Marc, B.1    Didier, P.2    Farida, D.3
  • 9
    • 0033840216 scopus 로고    scopus 로고
    • Chondrocyte differentiation in human osteoarthritis: Expression of osteocalcin in normal and osteoarthritic cartilage and bone
    • 10954778 10.1007/s002230001108 1:CAS:528:DC%2BD3cXmsVOku78%3D
    • Pullig O, Weseloh G, Ronneberger D-L, Käkönen S-M et al (2000) Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. Calcif Tissue Int 67:230-240
    • (2000) Calcif Tissue Int , vol.67 , pp. 230-240
    • Pullig, O.1    Weseloh, G.2    Ronneberger, D.-L.3    Käkönen, S.-M.4
  • 10
    • 55249086064 scopus 로고    scopus 로고
    • New insights into osteoarthritis: Recent susceptibility genes in osteoarthritis
    • 10.1097/BOR.0b013e32830aba48
    • Steffan DB, Eline PS, Ingrid M (2008) New insights into osteoarthritis: recent susceptibility genes in osteoarthritis. Curr Opin Rheumatol 20:553-559
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 553-559
    • Steffan, D.B.1    Eline, P.S.2    Ingrid, M.3
  • 11
    • 35748954326 scopus 로고    scopus 로고
    • Endochondral ossification: How cartilage is converted into bone in the developing skeleton
    • 17659995 10.1016/j.biocel.2007.06.009 1:CAS:528:DC%2BD2sXht1ylsb3J
    • Mackie EJ, Ahmed YA, Tatarczuch L et al (2008) Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 40:46-62
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 46-62
    • MacKie, E.J.1    Ahmed, Y.A.2    Tatarczuch, L.3
  • 12
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina E, Wenzel HM, Kreschel C et al (2001) BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 128:4523-4534
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3
  • 13
    • 0035071306 scopus 로고    scopus 로고
    • BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog
    • 11332615 10.1016/S0736-0266(00)00017-6 1:CAS:528:DC%2BD3MXjvVChtLg%3D
    • Grimsrud CD, Romano PR, D'Souza M et al (2001) BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog. J Orthop Res 19:18-25
    • (2001) J Orthop Res , vol.19 , pp. 18-25
    • Grimsrud, C.D.1    Romano, P.R.2    D'Souza, M.3
  • 14
    • 75649099043 scopus 로고    scopus 로고
    • Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer
    • 10.1186/ar2822
    • Steinert A, Proffen B, Kunz M et al (2009) Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther 11:148-162
    • (2009) Arthritis Res Ther , vol.11 , pp. 148-162
    • Steinert, A.1    Proffen, B.2    Kunz, M.3
  • 15
    • 0036744820 scopus 로고    scopus 로고
    • Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
    • Minina E, Kreschel C, Naski MC et al (2002) Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell 3:439-449
    • (2002) Dev Cell , vol.3 , pp. 439-449
    • Minina, E.1    Kreschel, C.2    Naski, M.C.3
  • 16
    • 64549088976 scopus 로고    scopus 로고
    • Thyroid hormone treatment of cultured chondrocytes mimics in vivo stimulation of collagen X mRNA by increasing BMP 4 expression
    • 10.1002/jcp.21704
    • Luisa L, Zeling N, Eleanor BG et al (2009) Thyroid hormone treatment of cultured chondrocytes mimics in vivo stimulation of collagen X mRNA by increasing BMP 4 expression. J Cell Physiol 219:595-605
    • (2009) J Cell Physiol , vol.219 , pp. 595-605
    • Luisa, L.1    Zeling, N.2    Eleanor, B.G.3
  • 17
    • 38749083863 scopus 로고    scopus 로고
    • Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes
    • 17708712 10.1359/jbmr.070806 1:CAS:528:DC%2BD2sXhsVyjtrnF
    • Wang L, Shao YY, Ballock RT (2007) Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. J Bone Miner Res 22:1988-1995
    • (2007) J Bone Miner Res , vol.22 , pp. 1988-1995
    • Wang, L.1    Shao, Y.Y.2    Ballock, R.T.3
  • 18
    • 0031709847 scopus 로고    scopus 로고
    • Thyroid hormone inhibits growth and stimulates terminal differentiation of epiphyseal growth plate chondrocytes
    • 10.1359/jbmr.1998.13.9.1398
    • Yoshinori I, Brian RG, Roy EW et al (1998) Thyroid hormone inhibits growth and stimulates terminal differentiation of epiphyseal growth plate chondrocytes. J Bone Miner Res 13:1398-1411
    • (1998) J Bone Miner Res , vol.13 , pp. 1398-1411
    • Yoshinori, I.1    Brian, R.G.2    Roy, E.W.3
  • 19
    • 38349166916 scopus 로고    scopus 로고
    • Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP
    • Jiang J, Leong NL, Mung JC et al (2008) Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP. Osteoarthritis Cartil 16:70-82
    • (2008) Osteoarthritis Cartil , vol.16 , pp. 70-82
    • Jiang, J.1    Leong, N.L.2    Mung, J.C.3
  • 20
    • 78149280272 scopus 로고    scopus 로고
    • Phenotypic variations in chondrocyte subpopulations and their response to in vitro culture and external stimuli
    • 10.1007/s10439-010-0096-1
    • Emily EC, John PF (2010) Phenotypic variations in chondrocyte subpopulations and their response to in vitro culture and external stimuli. Ann Biomed Eng 38:3371-3388
    • (2010) Ann Biomed Eng , vol.38 , pp. 3371-3388
    • Emily, E.C.1    John, P.F.2
  • 21
    • 33846386045 scopus 로고    scopus 로고
    • MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: A comparative study of three different aggrecan and glycosaminoglycan assays
    • Sumer EU, Sondergaard BC, Rousseau JC et al (2007) MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays. Osteoarthritis Cartil 15:212-221
    • (2007) Osteoarthritis Cartil , vol.15 , pp. 212-221
    • Sumer, E.U.1    Sondergaard, B.C.2    Rousseau, J.C.3
  • 22
    • 77049123522 scopus 로고    scopus 로고
    • Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
    • 20021645 10.1186/1756-0500-2-259
    • Wang B, Chen P, Jensen AC et al (2009) Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments. BMC Res Notes 2:259-266
    • (2009) BMC Res Notes , vol.2 , pp. 259-266
    • Wang, B.1    Chen, P.2    Jensen, A.C.3
  • 23
    • 79952766936 scopus 로고    scopus 로고
    • Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM-Increased serum CIIM in subjects with severe radiographic osteoarthritis
    • 21223960 10.1016/j.clinbiochem.2011.01.001 1:CAS:528:DC%2BC3MXjs1Wkur4%3D
    • Bay-Jensen AC, Liu Q, Byrjalsen I et al (2011) Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM-Increased serum CIIM in subjects with severe radiographic osteoarthritis. Clin Biochem 44:423-429
    • (2011) Clin Biochem , vol.44 , pp. 423-429
    • Bay-Jensen, A.C.1    Liu, Q.2    Byrjalsen, I.3
  • 24
    • 0028905018 scopus 로고
    • A rapid and ultrasensitive method for measurement of DNA, calcium and protein content, and alkaline phosphatase activity of chondrocyte cultures
    • 7538446 10.1007/BF00298620 1:CAS:528:DyaK2MXkvV2nsbY%3D
    • Teixeira CC, Hatori M, Leboy PS et al (1995) A rapid and ultrasensitive method for measurement of DNA, calcium and protein content, and alkaline phosphatase activity of chondrocyte cultures. Calcif Tissue Int 56:252-256
    • (1995) Calcif Tissue Int , vol.56 , pp. 252-256
    • Teixeira, C.C.1    Hatori, M.2    Leboy, P.S.3
  • 25
    • 33745622400 scopus 로고    scopus 로고
    • Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
    • Sondergaard BC, Wulf H, Henriksen K et al (2006) Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes. Osteoarthritis Cartil 14:759-768
    • (2006) Osteoarthritis Cartil , vol.14 , pp. 759-768
    • Sondergaard, B.C.1    Wulf, H.2    Henriksen, K.3
  • 26
    • 46749092075 scopus 로고    scopus 로고
    • Normalization strategies for mRNA expression data in cartilage research
    • Fundel K, Haag J, Gebhard PM et al (2008) Normalization strategies for mRNA expression data in cartilage research. Osteoarthritis Cartil 16:947-955
    • (2008) Osteoarthritis Cartil , vol.16 , pp. 947-955
    • Fundel, K.1    Haag, J.2    Gebhard, P.M.3
  • 27
    • 33745584358 scopus 로고    scopus 로고
    • Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation
    • Sondergaard BC, Henriksen K, Wulf H et al (2006) Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthritis Cartil 14:738-748
    • (2006) Osteoarthritis Cartil , vol.14 , pp. 738-748
    • Sondergaard, B.C.1    Henriksen, K.2    Wulf, H.3
  • 28
    • 0031042368 scopus 로고    scopus 로고
    • Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development
    • 1:CAS:528:DyaK2sXit1GqtL8%3D
    • Johansson N, Saarialho-Kere U, Airola K et al (1997) Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development. Dev Cell 208:387-397
    • (1997) Dev Cell , vol.208 , pp. 387-397
    • Johansson, N.1    Saarialho-Kere, U.2    Airola, K.3
  • 29
    • 0034083320 scopus 로고    scopus 로고
    • MMP-13 is induced during chondrocyte hypertrophy
    • 10771523 10.1002/(SICI)1097-4644(20000615)77:4<678: AID-JCB15>3.0.CO;2-P
    • D'Angelo M, Yan Z, Nooreyazdan M et al (2000) MMP-13 is induced during chondrocyte hypertrophy. J Cell Biochem 77:678-693
    • (2000) J Cell Biochem , vol.77 , pp. 678-693
    • D'Angelo, M.1    Yan, Z.2    Nooreyazdan, M.3
  • 30
    • 0023624645 scopus 로고
    • Changes in proteoglycan aggregates during cartilage mineralization
    • 3119178 10.1007/BF02555243 1:CAS:528:DyaL2sXmtlerur0%3D
    • Buckwalter JA, Rosenberg LC, Ungar R (1987) Changes in proteoglycan aggregates during cartilage mineralization. Calcif Tissue Int 41:228-236
    • (1987) Calcif Tissue Int , vol.41 , pp. 228-236
    • Buckwalter, J.A.1    Rosenberg, L.C.2    Ungar, R.3
  • 31
    • 0014493479 scopus 로고
    • Vesicles associated with calcification in the matrix of epiphyseal cartilage
    • Anderson HC (1969) Vesicles associated with calcification in the matrix of epiphyseal cartilage. J Cell Biol 41:59-72
    • (1969) J Cell Biol , vol.41 , pp. 59-72
    • Anderson, H.C.1
  • 32
    • 0014342768 scopus 로고
    • Evidence for changes in protein polysaccharide associated with the onset of calcification in cartilage
    • Matukas VJ, Krikos GA (1968) Evidence for changes in protein polysaccharide associated with the onset of calcification in cartilage. J Cell Biol 39:43-48
    • (1968) J Cell Biol , vol.39 , pp. 43-48
    • Matukas, V.J.1    Krikos, G.A.2
  • 33
    • 0028914071 scopus 로고
    • Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation
    • 7639109 10.1002/jbmr.5650100510 1:CAS:528:DyaK2MXmt1eqsbk%3D
    • Wroblewski J, Edwall-Arvidsson C (1995) Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation. J Bone Miner Res 10:735-742
    • (1995) J Bone Miner Res , vol.10 , pp. 735-742
    • Wroblewski, J.1    Edwall-Arvidsson, C.2
  • 34
    • 0032168880 scopus 로고    scopus 로고
    • Differential effects of local application of BMP-2 or TGF-[beta]1 on both articular cartilage composition and osteophyte formation
    • 10.1053/joca.1998.0129
    • van Beuningen HM, Glansbeek HL, van der Kraan PM et al (1998) Differential effects of local application of BMP-2 or TGF-[beta]1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartil 6:306-317
    • (1998) Osteoarthritis Cartil , vol.6 , pp. 306-317
    • Van Beuningen, H.M.1    Glansbeek, H.L.2    Van Der Kraan, P.M.3
  • 35
    • 0030027482 scopus 로고    scopus 로고
    • In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification
    • 8770703 10.1002/jbmr.5650110115 1:CAS:528:DyaK28Xht1Gnur0%3D
    • Alini M, Kofsky Y, Wu W et al (1996) In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. J Bone Miner Res 11:105-113
    • (1996) J Bone Miner Res , vol.11 , pp. 105-113
    • Alini, M.1    Kofsky, Y.2    Wu, W.3
  • 36
    • 0028222514 scopus 로고
    • Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: Arrest of type X collagen synthesis and net loss of collagen when calcification is initiated
    • 7942155 10.1002/jbmr.5650090716 1:CAS:528:DyaK2cXmt1Onsr0%3D
    • Alini M, Carey D, Hirata S et al (1994) Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: arrest of type X collagen synthesis and net loss of collagen when calcification is initiated. J Bone Miner Res 9:1077-1087
    • (1994) J Bone Miner Res , vol.9 , pp. 1077-1087
    • Alini, M.1    Carey, D.2    Hirata, S.3
  • 37
    • 33746886283 scopus 로고    scopus 로고
    • Animal models of osteoarthritis: Lessons learned while seeking the 'Holy Grail'
    • 16896297 10.1097/01.bor.0000240369.39713.af
    • Ameye LG, Young MF (2006) Animal models of osteoarthritis: lessons learned while seeking the 'Holy Grail'. Curr Opin Rheumatol 18:537-547
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 537-547
    • Ameye, L.G.1    Young, M.F.2
  • 38
    • 0037062469 scopus 로고    scopus 로고
    • Basic FGF mediates an immediate response of articular cartilage to mechanical injury
    • Vincent T, Hermansson M, Bolton M et al (2002) Basic FGF mediates an immediate response of articular cartilage to mechanical injury. Proc Natl Acad Sci U S A 99:8259-8264
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8259-8264
    • Vincent, T.1    Hermansson, M.2    Bolton, M.3
  • 39
    • 1842405367 scopus 로고    scopus 로고
    • Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development
    • Macias D, Ganan Y, Sampath TK et al (1997) Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development 124:1109-1117
    • (1997) Development , vol.124 , pp. 1109-1117
    • MacIas, D.1    Ganan, Y.2    Sampath, T.K.3
  • 40
    • 0037383836 scopus 로고    scopus 로고
    • Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte
    • 10.1016/S1063-4584(03)00004-9 1:STN:280:DC%2BD3s7msFWmsQ%3D%3D
    • Nakase T, Miyaji T, Tomita T et al (2003) Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartil 11:278-284
    • (2003) Osteoarthritis Cartil , vol.11 , pp. 278-284
    • Nakase, T.1    Miyaji, T.2    Tomita, T.3
  • 41
    • 0033752854 scopus 로고    scopus 로고
    • Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation
    • Robson H, Siebler T, Stevens DA et al (2000) Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation. Endocrinology 141:3887-3897
    • (2000) Endocrinology , vol.141 , pp. 3887-3897
    • Robson, H.1    Siebler, T.2    Stevens, D.A.3
  • 42
    • 44849113821 scopus 로고    scopus 로고
    • Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis
    • Meulenbelt I, Min JL, Bos S et al (2008) Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 17:1867-1875
    • (2008) Hum Mol Genet , vol.17 , pp. 1867-1875
    • Meulenbelt, I.1    Min, J.L.2    Bos, S.3
  • 43
    • 0026680526 scopus 로고
    • Matrix mineralization in hypertrophic chondrocyte cultures. Beta glycerophosphate increases type X collagen messenger RNA and the specific activity of pp 60c-src kinase
    • 1381978 10.1016/0169-6009(92)90850-D 1:STN:280:DyaK38vgsVyhsQ%3D%3D
    • Coe MR, Summers TA, Parsons SJ et al (1992) Matrix mineralization in hypertrophic chondrocyte cultures. Beta glycerophosphate increases type X collagen messenger RNA and the specific activity of pp 60c-src kinase. Bone Miner 18:91-106
    • (1992) Bone Miner , vol.18 , pp. 91-106
    • Coe, M.R.1    Summers, T.A.2    Parsons, S.J.3
  • 44
    • 0026555661 scopus 로고
    • Hypertrophic chondrocytes undergo further differentiation in culture
    • Descalzi Cancedda F, Gentili C, Manduca P et al (1992) Hypertrophic chondrocytes undergo further differentiation in culture. J Cell Biol 117:427-435
    • (1992) J Cell Biol , vol.117 , pp. 427-435
    • Descalzi Cancedda, F.1    Gentili, C.2    Manduca, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.