Design, synthesis, anti-inflammatory, analgesic screening, and molecular docking of some novel 2-pyridyl (3H)-quinazolin-4-one derivatives

Medicinal Chemistry Research

Volumn 22, Issue 2, 2013, Pages 1011-1020

  Eweas, Ahmad F ^a,b   El Nezhawy, Ahmed O H ^a,b   Baiuomy, Ayman R ^a,b   Awad, Mohamed M ^b,c  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b TAIF UNIVERSITY   (Saudi Arabia)

^c HELWAN UNIVERSITY   (Egypt)

Author keywords

(3H) Quinazolin 4 ones; Anti inflammatory; Molecular docking

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; 3 (4 (1 ACETYL 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL)PHENYL) 6 BROMO 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 3 (4 (2 AMINOTHIAZOL 4 YL)PHENYL) 6 BROMO 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 3 (4 ACETYLPHENYL) 6 BROMO 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 5 BROMO 2 (ISONICOTINAMIDO)BENZOIC ACID; 6 BROMO 2 (PYRIDIN 4 YL) 3 (4 (2 THIOCYANATOACETYL)PHENYL)QUINAZOLIN 4(3H) ONE; 6 BROMO 2 (PYRIDIN 4 YL) 3 (4 (3 (THIOPHEN 2 YL)ACRYLOYL)PHENYL)QUINAZOLIN 4(3H) ONE; 6 BROMO 2 (PYRIDIN 4 YL) 4H BENZO[D][1,3]OXAZIN 4 ONE; 6 BROMO 3 (4 (1 METHYL 5 (4 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (2 BROMOACETYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (2 HYDROXYTHIAZOL 4 YL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (3 (4 (DIMETHYLAMINO)PHENYL)ACRYLOYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (3 (4 CHLOROPHENYL)ACRYLOYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (3 (4 FLUOROPHENYL)ACRYLOYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (3 (4 NITROPHENYL)ACRYLOYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (3 (FURAN 2 YL)ACRYLOYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (5 (4 (DIMETHYLAMINO)PHENYL) 4,5 DIHYDROISOXAZOL 3 YL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO 3 (4 (6 (4 CHLOROPHENYL) 2 OXO 1,2,5,6 TETRAHYDROPYRIMIDIN 4 YL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; 6 BROMO-3 (4 (3 (4 METHOXYPHENYL)ACRYLOYL)PHENYL) 2 (PYRIDIN 4 YL)QUINAZOLIN 4(3H) ONE; AFLOQUALONE; AMINO ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CHALCONE DERIVATIVE; DIPROQUALONE; FLUPROQUAZONE; INDOMETACIN; PROQUAZONE; QUINAZOLINE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DOCKING; MOUSE; NONHUMAN;

EID: 84873990010     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0097-8     Document Type: Article

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