Synthesis and in vitro antifungal activity of some N,N-disubstituted dithiocarbamic acid esters derived from 2-methylquinazolinones

Bollettino Chimico Farmaceutico

Volumn 138, Issue 6, 1999, Pages 280-289

  Farghaly, A O ^a   Moharram, A M ^b  

^a Assiut University   (Egypt)

^b Assiut University   (Egypt)

Author keywords

Antifungal activity; APT; COSY; Differential scanning calorimetry (DSC); Ditiocarbamates; HETCOR; Quinazolinones

Indexed keywords

2 [(THIOCARBAMOYLTHIO)METHYL] QUINAZOLINONE DERIVATIVE; CLOTRIMAZOLE; DITHIOCARBAMIC ACID DERIVATIVE; QUINAZOLINONE DERIVATIVE; TOLNAFTATE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGICIDAL ACTIVITY; FUNGUS; FUNGUS GROWTH; GROWTH INHIBITION; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTIFUNGAL AGENTS; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; QUINAZOLINES; SPECTROPHOTOMETRY, INFRARED; THIOCARBAMATES;

EID: 0032804784     PISSN: 00066648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Koltin Y. Targets for antifungal drugs discovery. In Annual Reports in Medicinal Chemistry; Ed.; Bristol, J.A., Academic press; San Diego, California 1990, vol. 25, pp 141.
2. Powderly W.G., Kobayashi G.S., Herzig G.P., Medoff G., Amer. J. Med., 84, 826 (1988).
3. th ed. John-Willey and Sons., NY 1995, Vol. I, pp 637-652.
4. Schonenberger H., Lippert P.; Pharmazie 27, 139 (1972).
5. Gürsoy A., Ates Ö; Karali N., Cesur N., Kiraz M.; Eur. J. Med. Chem. 31, 643 (1996).
6. Ates Ö., Cesur N, Güner H., Kiraz M., Kaya D.; II Farmaco 50, 361 (1996).
7. Shah D.T., Walker E.M., Jones M.M., Singh P.K., Larsen B.; Annals of Clinical & Laboratory Sciences. 27, 282 (1997).
8. Chan J.H., Hong J.S., Kuyper L.F., Baccanari D.P., Joyner S.S., Tansik R.L., Boytos C.M., Rudolph S.K., J. Med. Chem. 38, 3608 (1995).
9. Chan J.H., Hong J.S., Kuyper L.F., Jones M.L., Baccanari D.P., Tansik R.L., Boytos C.M., Rudolph S.K., Brown A.D.; J. Heterocyclic Chem. 34, 145 (1997).
10. Sen A.B., Gupta, S.K., J. Indian Chem. Soc. 39, 368 (1962).
11. Mewada G.S.; Patel S.R., Shah, N.M., J. Indian Chem. Soc. 32, 199 (1955).
12. Gupta C.M.; Bhaduri A.P., Khanna N.M.; J. Med. Chem. 11, 392 (1986).
13. Mishiro J., Mosavuki I., Takashi T., Shimamoto T., Japan Kokai, 7529, 575 (1975), thropugh Chem. Abstr. 83, 114464y (1975).
14. Moubasher A.H., Mazen M.B.; Moharram A.M., El-Shanawany A.A.; Assiut Med. J. 17, 1 (1992).
15. Al-Doory V. (Ed.): Laboratory Medical Mycolgy. Lea & Febiger, Philadelphia, 1980.
16. Bauer A.W., Kirby W.M.M., Sherris J.C., Turk M.; Am. J. Clin. Pathol. 45, 493 (1966).
17. Armarego W.L.F.; J. Appl Chem. 11, 70 (1961).
18. Brown D.J.; Pyrimidines and their benzo derivatives, in Comprehensive Heterocyclic chemistry. Eds. Katritzky A.R. and Rees, C.R. , Pergamon Press, New York, Vol. 3, 11 (1984).
19. Kalinowski H.O., Berger S., Braun S., 13C-NMR Spektroskopie; George Thieme Verlag Stuttgart, New York 1984, p. 356.
20. Capan G., Ergenc N. Büyüktimkin S., Yulug N.; Sci. Pharm. 61, 243 (1993)
21. Naik D.V., Palamik G.J., Acta Crystallogr. 30B, 2396 (1974). C.A. 81, 160506v (1974).
22. Naik D.V., Palamik G.J., Acta Crystallogr. 30B, 2396 (1974). C.A. 81, 160506v (1974).
23. Bealieu F., Snieckus V., Synthesis 112 (1992).
24. Oki M.; Recent advances in atropoisomerism, in Topics in stereochemistry, Eds. Allinger, N.L.; Eliel, E.L.; Wilen, S.H.; vol. 14, John Wiley and Sons, New York, pp 10.