Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women

Journal of Bone and Mineral Research

Volumn 28, Issue 3, 2013, Pages 497-504

  Moseley, Kendall F ^a   Weaver, Connie M ^b   Appel, Lawrence ^c   Sebastian, Anthony ^d   Sellmeyer, Deborah E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ACID BASE; BONE; CITRATE; OSTEOPOROSIS; POTASSIUM

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; CITRATE CALCIUM; CITRATE POTASSIUM; COLECALCIFEROL; PARATHYROID HORMONE; PHOSPHORUS; PLACEBO; POTASSIUM;

ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; BONE TURNOVER; CALCIUM BALANCE; CALCIUM INTAKE; CALCIUM METABOLISM; CALCIUM URINE LEVEL; CALORIC INTAKE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EXCRETION; FAT INTAKE; FEMALE; HUMAN; INTESTINE ABSORPTION; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; POTASSIUM BLOOD LEVEL; POTASSIUM INTAKE; POTASSIUM URINE LEVEL; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; SODIUM INTAKE; URINARY EXCRETION;

AGED; BONE AND BONES; CALCIUM; FEMALE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; POTASSIUM CITRATE;

EID: 84873967344     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1764     Document Type: Article

References (24)

1. Frassetto L, Morris RC Jr, Sebastian A., Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am J Physiol. 1996; 271: 1114-22.
2. Lemann JJ, Bushinsky DA, Hamm LL., Bone buffering of acid and base in humans. Am J Physiol Renal Physiol. 2003 Nov; 285 (5): F811-32.
3. Sebastian A, Morris RC Jr., Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med. 1994; 331 (4): 279.
4. Dawson-Hughes B, Harris SS, Palermo NJ, Castaneda-Sceppa C, Rasmussen HM, Dallal GE., Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women. J Clin Endocrinol Metab. 2009 Jan; 94 (1): 96-102.
5. Lemann J Jr, Gray RW, Pleuss JA., Potassium bicarbonate, but not sodium bicarbonate, reduces urinary calcium excretion and improves calcium balance in healthy men. Kidney Int. 1989; 35: 688-95.
6. Lin PH, Ginty F, Appel LJ, Aickin M, Bohannon A, Garnero P, Barclay D, Svetkey LP., The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. J Nutr. 2003 Oct; 133 (10): 3130-6.
7. Marangella M, Di Stefano M, Casalis S, Berutti S, D'Amelio P, Isaia GC., Effects of potassium citrate supplementation on bone metabolism. Calcif Tissue Int. 2004; 74: 330-5.
8. Jehle S, Zanetti A, Muser J, Hulter HN, Krapf R., Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia. J Am Soc Nephrol. 2006 Nov; 17 (11): 3213-22.
9. Macdonald HM, Black AJ, Aucott L, Duthie G, Duthie S, Sandison R, Hardcastle AC, Lanham New SA, Fraser WD, Reid DM., Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. Am J Clin Nutr. 2008 Aug; 88 (2): 465-74.
10. Rafferty K, Davies KM, Heaney RP., Potassium intake and the calcium economy. J Am Coll Nutr. 2005 Apr; 24 (2): 99-106.
11. Block G, Woods M, Potosky A, Clifford C., Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990; 43: 1327-35.
12. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA., The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011 Jan; 96 (1): 53-8.
13. Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM, Schmülling C, Neugebauer E, Troidl H., Gastrointestinal Quality of Life Index: development, validation and application of a new instrument. Br J Surg. 1995; 82: 216-22.
14. Spence LA, Lipscomb ER, Cadogan J, Martin B, Wastney ME, Peacock M, Weaver CM., The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover study. Am J Clin Nutr. 2005 Apr; 81 (4): 916-22.
15. Yergey AL, Abrams SA, Vieira NE, Aldroubi A, Marini J, Sidbury JB., Determination of fractional absorption of dietary calcium in humans. J Nutr. 1994 May; 124: 674-82.
16. Lee W, McCabe GP, Martin BR, Weaver CM., Validation of a simple isotope method for estimating true calcium fractional absorption in adolescents. Osteoporos Int. 2011 Jan; 22 (1): 159-66.
17. Gyory AZ, Edwards KDG., Simultaneous titrimetric determination of bicarbonate and titratable acid of urine. Aust J Exp Biol Med Sci. 1967; 45: 141-7.
18. Lin SL, Chan JC., Urinary bicarbonate: a titrimetric method for determination. Clin Biochem. 1973 Sep; 6: 207-10.
19. Hollis BW, Kamerud JQ, Kurkowski A, Beaulieu J, Napoli JL., Quantification of circulating 1,25-dihydroxyvitamin D by radioimmunoassay with 125I-labeled tracer. Clin Chem. 1996 Apr; 42 (4): 586-92.
20. Sellmeyer DE, Schloetter M, Sebastian A., Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab. 2002; 87: 2008-12.
21. Sellmeyer DE, Stone KL, Sebastian A, Cummings SR., A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr. 2001 Jan; 73 (1): 118-22.
22. Sebastian A, Frassetto LA, Sellmeyer DE, et al. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr. 2002 Dec; 76 (6): 1308-16.
23. Sakhaee K, Maalouf NM, Abrams SA, Pak CY., Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal women. J Clin Endocrinol Metab. 2005 Jun; 90 (6): 3528-33.
24. Frassetto L, Morris RC Jr, Sebastian A., Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab. 2005 Feb; 90 (2): 831-4.