Perigranuloma localization and abnormal maturation of B cells emerging key players in sarcoidosis?

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 4, 2013, Pages 406-416

  Kamphuis, Lieke S ^a,b   Van Zelm, Menno C ^a   Lam, King H ^a   Rimmelzwaan, Guus F ^c   Baarsma, G Seerp ^d   Dik, Willem A ^a   Thio, H Bing ^a   Van Daele, Paul L ^a,b   Van Velthoven, Mirjam E ^d   Batstra, Manou R ^e   Van Hagen, P Martin ^a,b,d   Van Laar, Jan A ^a,b  

^a Department of Immunology ^*  (Netherlands)

^b Department of Internal Medicine   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d ROTTERDAM EYE HOSPITAL   (Netherlands)

^e REINIER DE GRAAF HOSPITAL   (Netherlands)

Author keywords

Immunoglobulin; Somatic hypermutation; TNF a; Vaccination response

Indexed keywords

CD27 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN HEAVY CHAIN; INFLUENZA VACCINE;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLUENZA VACCINATION; MALE; MEMORY CELL; PRIORITY JOURNAL; SARCOIDOSIS;

ADULT; AGED; ANTIGENS, CD27; B-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; GRANULOMA; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; ORTHOMYXOVIRIDAE; SARCOIDOSIS; YOUNG ADULT;

EID: 84873960799     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201206-1024OC     Document Type: Article

References (50)

1. Hinze CH, Colbert RA. B-cell depletion in Wegener's granulomatosis. Clin Rev Allergy Immunol 2008;34:327-379.
2. Nakken B, Munthe LA, Konttinen YT, Sandberg AK, Szekanecz Z, Alex P, Szodoray P. B-cells and their targeting in rheumatoid arthritis: current concepts and future perspectives. Autoimmun Rev 2011;11:28-34.
3. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med 2007;357:2153-2165.
4. Morgenthau AS, Iannuzzi MC. Recent advances in sarcoidosis. Chest 2011;139:174-182.
5. Baughman RP, Culver DA, Judson MA. A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med 2011;183:573-581.
6. Iannuzzi MC, Fontana Jr. Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. JAMA 2011;305:391-399.
7. Kamphuis LS, Lam-Tse WK, Dik WA, van Daele PL, van Biezen P, Kwekkeboom DJ, Kuijpers RW, Hooijkaas H, van Laar JA, Bastiaans J, et al. Efficacy of adalimumab in chronically active and symptomatic patients with sarcoidosis. Am J Respir Crit Care Med 2011;184:1214-1216.
8. Lee NS, Barber L, Akula SM, Siqounas G, Kataria YP, Arce S. Disturbed homeostasis and multiple signaling defects in the peripheral blood B-cell compartment of patients with severe chronic sarcoidosis. Clin Vaccine Immunol 2011;8:1306-1316.
9. Daniele RP, McMillan LJ, Dauber JH, Rossman MD. Immune complexes in sarcoidosis: a correlation with activity and duration of disease. Chest 1978;74:261-264.
10. Hunninghake GW, Crystal RG. Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis: site of increased antibody production and role of T lymphocytes. J Clin Invest 1981;67:86-92.
11. Weinberg I, Vasiliev L, Gotsman I. Anti-dsDNA antibodies in sarcoidosis. Semin Arthritis Rheum 2000;29:328-331.
12. Fazel SB, Howie SEM, Krajewski AS, Lamb D. B lymphocytes accumulations in human pulmonary sarcoidosis. Thorax 1992;47:964-967.
13. Gottenberg JE, Guillevin L, Lambotte O, Combe B, Allanore Y, Cantagrel A, Larroche C, Soubrier M, Bouillet L, Dougados M, et al. Club Rheumatismes et Inflammation (CRI). Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann Rheum Dis 2005;64:913-920.
14. Belkhou A, Younsi R, El Bouchti I, El Hassani S. Rituximab as a treatment alternative in sarcoidosis. Joint Bone Spine 2008;75:511-512.
15. Dasilva V, Breuil V, Chevallier P, Euller-Ziegler L. Relapse of severe sarcoidosis with an uncommon peritoneal location after TNF alpha blockade: efficacy of rituximab, report of a single case. Joint Bone Spine 2010;77:82-83.
16. Bomprezzi R, Pati S, Chansakul C, Vollmer T. A case of neurosarcoidosis successfully treated with rituximab. Neurology 2010;75: 568-570.
17. Artac H, Bozkurt B, Talim B, Reisli I. Sarcoid-like granulomas in common variable immunodeficiency. Rheumatol Int 2009;30:109-112.
18. Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, Vlkova M, Hernandez M, Detkova D, Bos PR, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 2008; 111:77-85.
19. Driessen GJ, van Zelm MC, van Hagen PM, Hartwig NG, Trip M, Warris A, de Vries E, Barendregt BH, Pico I, Hop W, et al. B-cell replication history and somatic hypermutation status identify distinct pathophysiological backgrounds in common variable immunodeficiency. Blood 2011;118:6814-6823.
20. Zhang M, Wang Z, Graner MW, Yang L, Liao M, Yang Q, Gou J, Zhu Y, Wu C, Liu H, et al. B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis. Cell Immunol 2011;270:217-223.
21. Gonzalez-Juarrero M, Turner OC, Turner J, Marietta P, Brooks JV, Orme IM. Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis. Infect Immun 2001;69:1722-1728.
22. Van Zelm MC, van der Burg M, de Ridder D, Barendregt BH, de Haas EF, Reinders MJ, Lankester AC, Révész T, Staal FJ, van Dongen JJ. Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J Immunol 2005;175:5912-5922.
23. Berkowska MA, van der Burg M, van Dongen JJ, van Zelm MC. Checkpoints of B cell differentiation: visualizing Ig-centric processes. Ann N Y Acad Sci 2011;1246:11-25.
24. Berkowska MA, Driessen GJ, Bikos V, Grosserichter-Wagener C, Stamatopoulos K, Cerutti A, He B, Biermann K, Lange JF, van der Burg M, et al. Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood 2011;118:2150-2158.
25. Kamphuis LSJ, van ZelmMC, de Haas EFE, TseWK, van Laar JAM, van Daele PLA, Baarsma GS, van Hagen PM. B-cell development in sarcoidosis [poster]. Presented at the European Workshop on Immune-Mediated Inflammatory Diseases. November 18-20, 2009, Cascais-Lisbon, Portugal. P29.
26. Kamphuis LSJ, van Zelm MC, de Haas EFE, Tse WK, van Laar JAM, van Daele PLA, van Hagen PM. B-cell maturation in a granulomatous disease [poster]. Presented at the XIVth European Society for Immunodeficiencies Meeting. October 6-9, 2010, Istanbul, Turkey. P202.
27. Kamphuis LSJ, van Zelm MC, van Hagen PM, de Haas EFE, Lam KH, Rimmelzwaan GF, van den Burg M, van Daele PLA, van Laar JA. Are B-cells emerging as key players in the pathogenesis of sarcoidosis? [poster]. Presented at the combined 10th World Association for Sarcoidosis and Other Granulomatous Disorders Meeting and 12th International Conference on BAL. June 15-18, 2011, Maastricht, the Netherlands. B8.
28. Vogtlander NP, Brown A, Valentijn RM, Rimmelzwaan GF, Osterhaus AD. Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients. Vaccine 2004;27:2469-2474.
29. European Committee for Proprietary Medicinal Products. Note for guidance on harmonisation of requirements for Influenza vaccines. (CPMP/BWP/214/96). London: European Agency for the Evaluation of Medicinal Products; 1997.
30. Center for Biologics Evaluation and Research. Guidance for industry: clinical data needed to support the licensure of pandemic influenza vaccines. Bethesda, MD: Food and Drug Administration; 2007.
31. Advisory Committee for Immunization Practices. Advisory Committee for Immunization Practices recommendations [accessed 2012 March 18]. Available from: http://www.cdc.gov/vaccines/pubs/ACIP-list.htm
32. Lefranc MP. IMGT databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr. Leukemia 2003;17:260-266.
33. Saklayen MG, Schroeter AL, Nafz MA, Jalil K. IgA deposition in the skin of patients with alcoholic liver disease. J Cutan Pathol 1996;23: 12-18.
34. Saussine A, Tazi A, Feuillet S, Rybojad M, Juillard C, Bergeron A, Dessirier V, Bouhidel F, Janin A, Bensussan A, et al. Active chronic sarcoidosis is characterized by increased transitional blood B cells, increased IL-10-producing regulatory B cells and high BAFF levels. PLoS ONE 2012;7:e43588.
35. Hasler P, Zouali M. B cell receptor signaling and autoimmunity. FASEB J 2001;15:2085-2098.
36. van Zelm MC, Reisli I, van der Burg M, Castano D, van Noesel CJ, van Tol MJ, Woellner C, Grimbacher B, Patino PJ, van Dongen JJ, et al. An antibody-deficiency syndrome due to mutations in the CD19 gene. N Engl J Med 2006;354:1901-1912.
37. Thiel J, Kimmig L, Salzer U, Grudzien M, Lebrecht D, Hagena T, Draeger R, Völxen N, Bergbreiter A, Jennings S, et al. Genetic CD21 deficiency is associated with hypogammaglobulinemia. J Allergy Clin Immunol 2012;129:801-810.
38. Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, et al. Acquisition of a multifunctional IgA1 plasma cell phenotype in the gut. Nature 2011;481:199-203.
39. Girard N, Cottin V, Hot A, Etienne-Mastroianni B, Chidiac C, Cordier JF. Opportunistic infections and sarcoidosis. RevMal Respir 2004;21:1083-1090.
40. Tavana S, Argani H, Gholamin S, Razavi SM, Keshtkar-Jahromi M, Talebian AS, Moqhaddam KG, Sepehri Z, Azad TM, Keshtkar- Jahromi M. Influenza vaccination in patients with pulmonary sarcoidosis: efficacy and safety. Influenza Other Respir Viruses 2012;6:136-141.
41. Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;4:251-262.
42. Zenz T, Mertens D, Küppers R, Döhner H, Stilgenbauer S. From pathogenesis to treatment of chronic lymphocytic leukaemia: BCR response and IGHV mutation. Nat Rev Cancer 2010;10:37-50.
43. Papanikolaou IC, Sharma OP. The relationship between sarcoidosis and lymphoma. Eur Respir J 2010;36:1207-1219.
44. García Casares E, Mateo Soria L, García Melchor E, Mínguez Blasco S, Vall-Llobera Calmet F, Canellas Oliver G, Holgado Pérez S. Sarcoidosis-lymphoma syndrome. Reumatol Clin. 2009;1:31-33.
45. Karakantza M, Matutes E, McLennan K, O'Connor NT, Srivastava PC, Catovsky D. Association between sarcoidosis and lymphoma revisited. J Clin Pathol 1996;49:208-212.
46. Cunningham-Rundles C. Autoimmune manifestations in common variable immunodeficiency. J Clin Immunol 2008;S42-S45.
47. Ardeniz O, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Clin Immunol 2009;133:198-207.
48. Sweiss NJ, Salloum R, Ghandi S, Alegre ML, Sawaqed R, Badaracco M, Pursell K, Pitrak D, Baughman RP, Moller DR, et al. Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS ONE 2010;5:e9088.
49. Hermaszewski RA, Webster AD. Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med 1993; 86:31-42.
50. Chen H, Liao O, Holl TM, Snowden P, Ueda Y, Kelsoe G. Genetic regulation of pristine-induced oil granuloma responses. Int J Exp Pathol 2010;91:472-483.