High-throughput selectivity assays for small-molecule inhibitors of β-catenin/T-cell factor protein-protein interactions

ACS Medicinal Chemistry Letters

Volumn 4, Issue 2, 2013, Pages 306-311

  Zhang, Min ^a   Catrow, J Leon ^a   Ji, Haitao ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

catenin; adenomatous polyposis coli; AlphaScreen; E cadherin; fluorescence polarization; inhibitor selectivity; protein protein interactions; T cell factor; Wnt signaling

Indexed keywords

APC PROTEIN; BETA CATENIN; CGP 049090; GLYCOGEN SYNTHASE KINASE 3; PKF 115 584; PKF 118 310; PROTEIN INHIBITOR; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ALPHASCREEN ASSAY; ARTICLE; ASSAY; CRYSTALLOGRAPHY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; FIBROSIS; FLUORESCENCE POLARIZATION; HUMAN; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; WNT SIGNALING PATHWAY;

EID: 84873960409     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300367f     Document Type: Article

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