Two Cases of Uveal Amelanotic Melanoma in Transgenic Tyr-HRAS+ Ink4a/Arf Heterozygous Mice

Toxicologic Pathology

Volumn 35, Issue 6, 2007, Pages 825-830

  Latendresse, John R ^a   Muskhelishvili, Levan ^a   Warbritton, Alan ^a   Tolleson, William H ^b  

^a Toxicologic Pathology Associates   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

amelanotic; animal models; immunohistochemistry; Ink4a Arf; mouse pathology; transgenic animals; Uveal melanoma

Indexed keywords

CDKN2A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MONOPHENOL MONOOXYGENASE; UNCLASSIFIED DRUG;

AMELANOTIC MELANOMA; ANIMAL; ARTICLE; DISEASE MODEL; FEMALE; GENETICS; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; ONCOGENE RAS; PATHOLOGY; TRANSGENIC MOUSE; UVEA TUMOR;

ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; FEMALE; GENES, RAS; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA, AMELANOTIC; MICE; MICE, TRANSGENIC; MONOPHENOL MONOOXYGENASE; UVEAL NEOPLASMS;

EID: 84873937053     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230701584221     Document Type: Article

References (44)

1. Beermann F Hunziker A Foletti A Transgenic mouse models for tumors of melanocytes and retinal pigment epithelium Pigment Cell Res 1999 12 71 80
2. Bonicel P Michelot J Bacin F Papon J Kemeny JL Moins N Morvan D Madelmont JC Establishment of IPC 227 cells as human xenografts in rabbits: a model of uveal melanoma Melanoma Res 2000 10 445 50
3. Bradl M Klein-Szanto A Porter S Mintz B Malignant melanoma in transgenic mice Proc Natl Acad Sci U S A 1991 88 164 8
4. Calipel A Mouriaux F Glotin AL Malecaze F Faussat AM Mascarelli F Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells J Biol Chem 2006 281 9238 50
5. Char DH Clinical Ocular Oncology 1997 Philadelphia Lippincott-Raven
6. Chesa PG Rettig WJ Melamed MR Old LJ Niman HL Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy Proc Natl Acad Sci U S A 1987 84 3234 8
7. Chin L Jr Dubielzig RR Albert DM Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf−/− mice Arch Ophthalmol 2005 123 1088 94
8. Chin L Pomerantz J Polsky D Jacobson M Cohen C Cordon-Cardo C Horner JW 2nd DePinho RA Cooperative effects of INK4a and ras in melanoma susceptibility in vivo Genes Dev 1997 11 2822 34
9. de Snoo FA Hayward NK Cutaneous melanoma susceptibility and progression genes Cancer Lett 2005 230 153 86
10. Dithmar S Albert DM Grossniklaus HE Animal models of uveal melanoma Melanoma Res 2000 10 195 211
11. Edmunds SC Kelsell DP Hungerford JL Cree IA Mutational analysis of selected genes in the TGFbeta, Wnt, pRb, and p53 pathways in primary uveal melanoma Invest Ophthalmol Vis Sci 2002 43 2845 51
12. Egan KM Seddon JM Glynn RJ Gragoudas ES Albert DM Epidemiologic aspects of uveal melanoma Surv Ophthalmol 1988 32 239 51
13. Goel VK Lazar AJ Warneke CL Redston MS Haluska FG Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma J Invest Dermatol 2006 126 154 60
14. Gotz W Theuring F Favor J Herken R Eye pathology in transgenic mice carrying a MSV-SV 40 large T-construct Exp Eye Res 1991 52 41 9
15. Hoar RM Embryology of the eye Environ Health Perspect 1982 44 31 4
16. Hovland PG Trempe C Genomic investigations of posterior uveal melanoma Semin Ophthalmol 2005 20 231 8
17. Hurst EA Harbour JW Cornelius LA Ocular melanoma: a review and the relationship to cutaneous melanoma Arch Dermatol 2003 139 1067 73
18. Hyde RK Griep AE Unique roles for E2F1 in the mouse lens in the absence of functional pRB proteins Invest Ophthalmol Vis Sci 2002 43 1509 16
19. Karimipour DJ Lowe L Su L Hamilton T Sondak V Johnson TM Fullen D Standard immunostains for melanoma in sentinel lymph node specimens: which ones are most useful? J Am Acad Dermatol 2004 50 759 64
20. Koenig A Wojcieszyn J Weeks BR Modiano JF Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma Vet Pathol 2001 38 427 35
21. Kramer TR Powell MB Wilson MM Salvatore J Grossniklaus HE Pigmented uveal tumours in a transgenic mouse model Br J Ophthalmol 1998 82 953 60
22. Latendresse J Warbritton A Jonassen H Creasy D Fixation of testes and eyes using a modified Davidson’s fluid: Comparison with Bouin’s Fluid and Conventional Davidson’s Fluid Toxicol Pathol 2002 30 524 33
23. Lim E Browning J MacGregor D Davis ID Cebon JS Desmoplastic melanoma: comparison of expression of differentiation antigens and cancer testis antigens Melanoma Res 2006 16 347 55
24. McLaren BK Ma L Desmoplastic malignant melanoma: exposing the great masquerade J Histotechnol 2003 26 245 51
25. Merbs SL Sidransky D Analysis of p16 (CDKN2/MTS-1/INK4A) alterations in primary sporadic uveal melanoma Invest Ophthalmol Vis Sci 1999 40 779 83
26. Morgenbesser SD Williams BO Jacks T DePinho RA p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens Nature 1994 371 72 4
27. Mueller AJ Folberg R Freeman WR Bartsch DU Bergeron-Lynn G Mehaffey MG Kan-Mitchell J Huang X Jian G Avila C Taskintuna I Cheng L Wang J Evaluation of the human choroidal melanoma rabbit model for studying microcirculation patterns with confocal ICG and histology Exp Eye Res 1999 68 671 8
28. Onken MD Ehlers JP Worley LA Makita J Yokota Y Harbour JW Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas Cancer Res 2006 66 4602 9
29. Onken MD Worley LA Ehlers JP Harbour JW Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death Cancer Res 2004 64 7205 9
30. Pan H Griep AE Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development Genes Dev 1994 8 1285 99
31. Powell MB Hyman P Bell OD Balmain A Brown K Alberts D Bowden GT Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter Mol Carcinog 1995 12 82 90
32. Serrano M Lee H Chin L Cordon-Cardo C Beach D DePinho RA Role of the INK4a locus in tumor suppression and cell mortality Cell 1996 85 27 37
33. Shields CL Shields JA Materin M Gershenbaum E Singh AD Smith A Iris melanoma: risk factors for metastasis in 169 consecutive patients Ophthalmology 2001 108 172 8
34. Smith SH Goldschmidt MH McManus PM A comparative review of melanocytic neoplasms Vet Pathol 2002 39 651 78
35. Soufir N Bressac-de Paillerets B Desjardins L Levy C Bombled J Gorin I Schlienger P Stoppa-Lyonnet D Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16INK4A, P14ARF or cdk4 genes Br J Cancer 2000 82 818 22
36. Straume O Smeds J Kumar R Hemminki K Akslen LA Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CKDN2A in cutaneous melanoma of the vertical growth phase Am J Pathol 2002 161 229 37
37. Syed NA Windle JJ Darjatmoko SR Lokken JM Steeves RA Chappell R Wallow IH Koop BA Mangold G Howes KA Albert DM Transgenic mice with pigmented intraocular tumors: tissue of origin and treatment Invest Ophthalmol Vis Sci 1998 39 2800 5
38. Tolleson WH Human melanocyte biology, toxicology, and pathology J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2005 23 105 61
39. Tolleson WH Doss JC Latendresse J Warbritton AR Melchior WB Jr Chin L Dubielzig RR Albert DM Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+Ink4a/Arf−/− mice Arch Ophthalmol 2005 123 1088 94
40. Tolleson WH Doss JC Latendresse J Warbritton AR Melchior WB Vajdic C Kricker A Duffy DL Aitken JF Stark M ter Huurne JA Martin NG Armstrong BK Hayward NK Ocular melanoma is not associated with CKDN2A or MC1R variants–a population-based study Melanoma Res 2003 13 409 13
41. Vajdic C Kricker A Duffy DL Aitken JF Stark M ter Huurne JA Martin NG Armstrong BK Hayward NK Ocular melanoma is not associated with CDKN2A or MCIR variants—a population-based study Melanoma Res 2003 13 409 13
42. Wick MR Patterson JW Multimodal pathologic diagnosis of malignant melanoma: integration of morphology, histochemistry, immunohistology, and electron microscopy J Histotechnol 2003 26 253 8
43. Woll E Bedikian A Legha SS Uveal melanoma: natural history and treatment options for metastatic disease Melanoma Res 1999 9 575 81
44. Zuidervaart W van Nieuwpoort F Stark M Dijkman R Packer L Borgstein AM Pavey S van der Velden P Out C Jager MJ Hayward NK Gruis NA Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS Br J Cancer 2005 92 2032 8