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Volumn 24, Issue 2, 2013, Pages 530-537

Cutaneous effects of BRAF inhibitor therapy: A case series

Author keywords

BRAF inhibitor; Cutaneous squamous cell carcinoma; MEK inhibitor; Photosensitivity; Side effects

Indexed keywords

DABRAFENIB; GSK 112021; TRAMETINIB; UNCLASSIFIED DRUG; VEMURAFENIB;

EID: 84873876998     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mds292     Document Type: Article
Times cited : (72)

References (46)
  • 1
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C et al Mutations of the BRAF gene in human cancer. Nature 2002; 417(6892): 949-954.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 2
    • 65649108998 scopus 로고    scopus 로고
    • AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: an open-label, randomized, multicenter, phase II study
    • Abstr 9033
    • Dummer R, Robert C, Chapman PB et al AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: an open-label, randomized, multicenter, phase II study. J Clin Oncol 2008; 26(Suppl): (Abstr 9033).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Dummer, R.1    Robert, C.2    Chapman, P.B.3
  • 3
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PT, Garnett MJ, Roe SM et al Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004; 116(6): 855-867.
    • (2004) Cell , vol.116 , Issue.6 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3
  • 4
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C et al Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364(26): 2507-2516.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 5
    • 77954218212 scopus 로고    scopus 로고
    • BRAF as therapeutic target in melanoma
    • Wellbrock C, Hurlstone A. BRAF as therapeutic target in melanoma. Biochem Pharmacol 2010; 80(5): 561-567.
    • (2010) Biochem Pharmacol , vol.80 , Issue.5 , pp. 561-567
    • Wellbrock, C.1    Hurlstone, A.2
  • 6
    • 0348059883 scopus 로고    scopus 로고
    • Zelboraf [package insert]. CA: Genentech Inc. 2011
    • Zelboraf [package insert]. San Francisco, CA: Genentech Inc. 2011.
    • San Francisco
  • 7
    • 79952765808 scopus 로고    scopus 로고
    • Sorafenib-induced premalignant and malignant skin lesions
    • Williams VL, Cohen PR, Stewart DJ. Sorafenib-induced premalignant and malignant skin lesions. Int J Dermatol 2011; 50(4): 396-402.
    • (2011) Int J Dermatol , vol.50 , Issue.4 , pp. 396-402
    • Williams, V.L.1    Cohen, P.R.2    Stewart, D.J.3
  • 8
    • 68849111836 scopus 로고    scopus 로고
    • The histologic spectrum of epithelial neoplasms induced by sorafenib
    • Kwon EJ, Kish LS, Jaworsky C. The histologic spectrum of epithelial neoplasms induced by sorafenib. J Am Acad Dermatol 2009; 61(3): 522-527.
    • (2009) J Am Acad Dermatol , vol.61 , Issue.3 , pp. 522-527
    • Kwon, E.J.1    Kish, L.S.2    Jaworsky, C.3
  • 10
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB et al Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010; 363(9): 809-819.
    • (2010) N Engl J Med , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 11
    • 79959776574 scopus 로고    scopus 로고
    • BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutationpositive metastatic melanoma
    • Abstr 8509
    • Ribas A, Kim KB, Schuchter LM et al BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutationpositive metastatic melanoma. J Clin Oncol 2011; 29(Suppl): (Abstr 8509).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Ribas, A.1    Kim, K.B.2    Schuchter, L.M.3
  • 12
    • 27144510955 scopus 로고    scopus 로고
    • Non-melanoma skin cancer: what drives tumor development and progression?
    • Boukamp P. Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 2005; 26(10): 1657-1667.
    • (2005) Carcinogenesis , vol.26 , Issue.10 , pp. 1657-1667
    • Boukamp, P.1
  • 13
    • 0037217819 scopus 로고    scopus 로고
    • TP53 mutations in human skin cancers
    • Giglia-Mari G, Sarasin A. TP53 mutations in human skin cancers. Hum Mutat 2003; 21(3): 217-228.
    • (2003) Hum Mutat , vol.21 , Issue.3 , pp. 217-228
    • Giglia-Mari, G.1    Sarasin, A.2
  • 14
    • 84873823736 scopus 로고    scopus 로고
    • BRAF-targeted therapy for metastatic melanoma: rationale, clinical activity and safety
    • Noor R, Trinh V, Kim K et al. BRAF-targeted therapy for metastatic melanoma: rationale, clinical activity and safety. Clin Invest 2011; 1(8): 1127-1139.
    • (2011) Clin Invest , vol.1 , Issue.8 , pp. 1127-1139
    • Noor, R.1    Trinh, V.2    Kim, K.3
  • 15
    • 84862908097 scopus 로고    scopus 로고
    • RAS mutations in cutaneous squamous cell carcinomas with BRAF inhibitors
    • Su F, Viros A, Milagre C et al RAS mutations in cutaneous squamous cell carcinomas with BRAF inhibitors. N Engl J Med 2012; 366(3): 207-215.
    • (2012) N Engl J Med , vol.366 , Issue.3 , pp. 207-215
    • Su, F.1    Viros, A.2    Milagre, C.3
  • 16
    • 0030841557 scopus 로고    scopus 로고
    • Skin autografts in epidermodysplasia verruciformis: human papillomavirus-associated cutaneous changes need over 20 years for malignant conversion
    • Majewski S, Jablonska S. Skin autografts in epidermodysplasia verruciformis: human papillomavirus-associated cutaneous changes need over 20 years for malignant conversion. Cancer Res 1997; 57(19): 4214-4216.
    • (1997) Cancer Res , vol.57 , Issue.19 , pp. 4214-4216
    • Majewski, S.1    Jablonska, S.2
  • 17
    • 0034091523 scopus 로고    scopus 로고
    • Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals
    • Harwood CA, Surentheran T, McGregor JM et al Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. J Med Virol 2000; 61(3): 289-297.
    • (2000) J Med Virol , vol.61 , Issue.3 , pp. 289-297
    • Harwood, C.A.1    Surentheran, T.2    McGregor, J.M.3
  • 18
    • 0027448540 scopus 로고
    • Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus
    • Purdie KJ, Sexton CJ, Proby CM et al Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus. Cancer Res 1993; 53(21): 5328-5333.
    • (1993) Cancer Res , vol.53 , Issue.21 , pp. 5328-5333
    • Purdie, K.J.1    Sexton, C.J.2    Proby, C.M.3
  • 19
    • 0028795617 scopus 로고
    • Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients
    • Berkhout RJ, Tieben LM, Smits HL et al. Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients. J Clin Microbiol 1995; 33 (3): 690-695.
    • (1995) J Clin Microbiol , vol.33 , Issue.3 , pp. 690-695
    • Berkhout, R.J.1    Tieben, L.M.2    Smits, H.L.3
  • 20
    • 0030919310 scopus 로고    scopus 로고
    • Papillomavirus and HPV typing
    • de Villiers EM. Papillomavirus and HPV typing. Clin Dermatol 1997; 15(2): 199-206.
    • (1997) Clin Dermatol , vol.15 , Issue.2 , pp. 199-206
    • De Villiers, E.M.1
  • 21
    • 15844386535 scopus 로고    scopus 로고
    • Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients
    • Shamanin V, Zur Hausen H, Lavergne D et al Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. J Natl Cancer Inst 1996; 88(12): 802-811.
    • (1996) J Natl Cancer Inst , vol.88 , Issue.12 , pp. 802-811
    • Shamanin, V.1    Zur Hausen, H.2    Lavergne, D.3
  • 22
    • 0028068160 scopus 로고
    • Detection of epidermodysplasia verruciformis-like human papillomavirus types in malignant and premalignant skin lesions of renal transplant recipients
    • Tieben LM, Berkhout RJ, Smits HL et al Detection of epidermodysplasia verruciformis-like human papillomavirus types in malignant and premalignant skin lesions of renal transplant recipients. Br J Dermatol 1994; 131(2): 226-230.
    • (1994) Br J Dermatol , vol.131 , Issue.2 , pp. 226-230
    • Tieben, L.M.1    Berkhout, R.J.2    Smits, H.L.3
  • 23
    • 79956153091 scopus 로고    scopus 로고
    • Ungual and periungual human papillomavirusassociated squamous cell carcinoma: a review
    • Riddel C, Rashid R, Thomas V. Ungual and periungual human papillomavirusassociated squamous cell carcinoma: a review. J Am Acad Dermatol 2011; 64(6): 1147-1153.
    • (2011) J Am Acad Dermatol , vol.64 , Issue.6 , pp. 1147-1153
    • Riddel, C.1    Rashid, R.2    Thomas, V.3
  • 24
    • 0242442472 scopus 로고    scopus 로고
    • The prevalence of human papillomavirus genotypes in nonmelanoma skin cancers of nonimmunosuppressed individuals identifies high-risk genital types as possible risk factors
    • Iftner A, Klug SJ, Garbe C et al The prevalence of human papillomavirus genotypes in nonmelanoma skin cancers of nonimmunosuppressed individuals identifies high-risk genital types as possible risk factors. Cancer Res 2003; 63 (21): 7515-7519.
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7515-7519
    • Iftner, A.1    Klug, S.J.2    Garbe, C.3
  • 25
    • 43749125071 scopus 로고    scopus 로고
    • Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals
    • Asgari MM, Kiviat NB, Critchlow CW et al Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals. J Invest Dermatol 2008; 128(6): 1409-1417.
    • (2008) J Invest Dermatol , vol.128 , Issue.6 , pp. 1409-1417
    • Asgari, M.M.1    Kiviat, N.B.2    Critchlow, C.W.3
  • 26
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn SJ, Milagre C, Whittaker S et al Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010; 140(2): 209-221.
    • (2010) Cell , vol.140 , Issue.2 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3
  • 27
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou G, Song K, Yen I et al RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010; 464(7287): 431-435.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3
  • 28
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos PI, Zhang C, Bollag G et al. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010; 464(7287): 427-430.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3
  • 29
    • 0032524855 scopus 로고    scopus 로고
    • Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases
    • Zhang YL, Keng YF, Zhao Y et al. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. J Biol Chem 1998; 273(20): 12281-7.
    • (1998) J Biol Chem , vol.273 , Issue.20 , pp. 12281-12287
    • Zhang, Y.L.1    Keng, Y.F.2    Zhao, Y.3
  • 30
    • 0030064449 scopus 로고    scopus 로고
    • Keratoacanthomas and skin neoplasms associated with suramin therapy
    • Kobayashi K, Pezen DS, Vogelzang NJ et al Keratoacanthomas and skin neoplasms associated with suramin therapy. Arch Dermatol 1996; 132(1): 96-98.
    • (1996) Arch Dermatol , vol.132 , Issue.1 , pp. 96-98
    • Kobayashi, K.1    Pezen, D.S.2    Vogelzang, N.J.3
  • 31
    • 0030772291 scopus 로고    scopus 로고
    • Suramin keratosis: a unique skin eruption in a patient receiving suramin for metastatic prostate cancer
    • Kenner JR, Sperling LC, Waselenko J et al. Suramin keratosis: a unique skin eruption in a patient receiving suramin for metastatic prostate cancer. J Urol 1997; 158(6): 2245-2246.
    • (1997) J Urol , vol.158 , Issue.6 , pp. 2245-2246
    • Kenner, J.R.1    Sperling, L.C.2    Waselenko, J.3
  • 32
    • 65249127575 scopus 로고    scopus 로고
    • Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib
    • Dubauskas Z, Kunishige J, Prieto VG et al. Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib. Clin Genitourin Cancer 2009; 7(1): 20-23.
    • (2009) Clin Genitourin Cancer , vol.7 , Issue.1 , pp. 20-23
    • Dubauskas, Z.1    Kunishige, J.2    Prieto, V.G.3
  • 33
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM et al Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356(2): 125-134.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 34
    • 84861393212 scopus 로고    scopus 로고
    • Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway
    • Huang V, Hepper D, Anadkat M et al. Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway. Arch Dermatol 2012; 148(5): 628-633.
    • (2012) Arch Dermatol , vol.148 , Issue.5 , pp. 628-633
    • Huang, V.1    Hepper, D.2    Anadkat, M.3
  • 35
    • 80053154225 scopus 로고    scopus 로고
    • Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436)
    • Abstr CRA8503
    • Infante JR, Falchook GS, Lawrence DP et al Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436). J Clin Oncol 2011; 29(Suppl): (Abstr CRA8503).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Infante, J.R.1    Falchook, G.S.2    Lawrence, D.P.3
  • 37
    • 0037949471 scopus 로고    scopus 로고
    • A broad spectrum of human papillomavirus types is present in the skin of Australian patients with non-melanoma skin cancers and solar keratosis
    • Forslund O, Ly H, Reid C et al. A broad spectrum of human papillomavirus types is present in the skin of Australian patients with non-melanoma skin cancers and solar keratosis. Br J Dermatol 2003; 149(1): 64-73.
    • (2003) Br J Dermatol , vol.149 , Issue.1 , pp. 64-73
    • Forslund, O.1    Ly, H.R.2
  • 38
    • 0028325368 scopus 로고
    • Risk of genital human papillomavirus infection in women with human immunodeficiency virus-induced immunosuppression
    • Ho GY, Burk RD, Fleming I et al. Risk of genital human papillomavirus infection in women with human immunodeficiency virus-induced immunosuppression. Int J Cancer 1994; 56(6): 788-792.
    • (1994) Int J Cancer , vol.56 , Issue.6 , pp. 788-792
    • Ho, G.Y.1    Burk, R.D.2    Fleming, I.3
  • 39
    • 3042821260 scopus 로고    scopus 로고
    • Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18
    • Giampieri S, Storey A. Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18. Br J Cancer 2004; 90(11): 2203-2209.
    • (2004) Br J Cancer , vol.90 , Issue.11 , pp. 2203-2209
    • Giampieri, S.1    Storey, A.2
  • 40
    • 1242319406 scopus 로고    scopus 로고
    • Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins
    • Duensing S, Munger K. Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins. Int J Cancer 2004; 109(2): 157-162.
    • (2004) Int J Cancer , vol.109 , Issue.2 , pp. 157-162
    • Duensing, S.1    Munger, K.2
  • 41
    • 78650391890 scopus 로고    scopus 로고
    • The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
    • Comin-Anduix B, Chodon T, Sazegar H et al The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations. Clin Cancer Res 2010; 16(24): 6040-6048.
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 6040-6048
    • Comin-Anduix, B.1    Chodon, T.2    Sazegar, H.3
  • 42
    • 0026544710 scopus 로고
    • Squamous cell carcinoma of the skin (excluding lip and oral mucosa)
    • Johnson TM, Rowe DE, Nelson BR et al. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 1992; 26(3 Pt 2): 467-484.
    • (1992) J Am Acad Dermatol , vol.26 , Issue.3 PT 2 , pp. 467-484
    • Johnson, T.M.1    Rowe, D.E.2    Nelson, B.R.3
  • 43
    • 55949104588 scopus 로고    scopus 로고
    • Milia: a review and classification
    • Berk DR, Bayliss SJ. Milia: a review and classification. J Am Acad Dermatol 2008; 59(6): 1050-1063.
    • (2008) J Am Acad Dermatol , vol.59 , Issue.6 , pp. 1050-1063
    • Berk, D.R.1    Bayliss, S.J.2
  • 44
    • 79955970528 scopus 로고    scopus 로고
    • Management of tyrosine kinase inhibitor-induced hand-foot skin reaction: viewpoints from the medical oncologist, dermatologist, and oncology nurse
    • Manchen E, Robert C, Porta C. Management of tyrosine kinase inhibitor-induced hand-foot skin reaction: viewpoints from the medical oncologist, dermatologist, and oncology nurse. J Support Oncol 2011; 9(1): 13-23.
    • (2011) J Support Oncol , vol.9 , Issue.1 , pp. 13-23
    • Manchen, E.1    Robert, C.2    Porta, C.3
  • 45
    • 78049519723 scopus 로고    scopus 로고
    • Cutaneous reactions to epidermal growth factor receptor inhibitors
    • Pomerantz RG, Mirvish ED, Geskin LJ. Cutaneous reactions to epidermal growth factor receptor inhibitors. J Drugs Dermatol 2010; 9(10): 1229-1234.
    • (2010) J Drugs Dermatol , vol.9 , Issue.10 , pp. 1229-1234
    • Pomerantz, R.G.1    Mirvish, E.D.2    Geskin, L.J.3
  • 46
    • 80755177739 scopus 로고    scopus 로고
    • Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244 ARRY-142886)
    • Balagula Y, Barth Huston K, Busam KJ et al. Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886). Invest New Drugs 2011; 29(5): 1114-1121.
    • (2011) Invest New Drugs , vol.29 , Issue.5 , pp. 1114-1121
    • Balagula, Y.1    Barth Huston, K.2    Busam, K.J.3


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