Experimental Pain and Opioid Analgesia in Volunteers at High Risk for Obstructive Sleep Apnea

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Doufas, Anthony G ^a,d   Tian, Lu ^a   Padrez, Kevin A ^b,e   Suwanprathes, Puntarica ^c   Cardell, James A ^c   Maecker, Holden T ^a   Panousis, Periklis ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; PLACEBO; REMIFENTANIL; SOMATOMEDIN BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANALGESIA; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; HIGH RISK PATIENT; HUMAN; HYPOXIA; MALE; OXYGEN SATURATION; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; POLYSOMNOGRAPHY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SLEEP DISORDERED BREATHING;

ADULT; ANALGESICS, OPIOID; ANOXIA; BIOLOGICAL MARKERS; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; PAIN; PAIN THRESHOLD; PIPERIDINES; SLEEP; SLEEP APNEA, OBSTRUCTIVE; YOUNG ADULT;

EID: 84873872580     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054807     Document Type: Article

References (89)

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230-1235.
2. Young T, Peppard PE, Gottlieb DJ, (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165: 1217-1239.
3. Dempsey JA, Veasey SC, Morgan BJ, O'Donnell CP, (2010) Pathophysiology of sleep apnea. Physiol Rev 90: 47-112.
4. Finkel KJ, Searleman AC, Tymkew H, Tanaka CY, Saager L, et al. (2009) Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center. Sleep Med 10: 753-758.
5. Young T, Evans L, Finn L, Palta M, (1997) Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep 20: 705-706.
6. Peppard PE, Young T, Palta M, Skatrud J, (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342: 1378-1384.
7. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, et al. (2005) Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353: 2034-2041.
8. Punjabi NM, Beamer BA, (2009) Alterations in Glucose Disposal in Sleep-disordered Breathing. Am J Respir Crit Care Med 179: 235-240.
9. Brown KA, Morin I, Hickey C, Manoukian JJ, Nixon GM, et al. (2003) Urgent adenotonsillectomy: an analysis of risk factors associated with postoperative respiratory morbidity. Anesthesiology 99: 586-595.
10. Ankichetty S, Chung F, (2011) Considerations for patients with obstructive sleep apnea undergoing ambulatory surgery. Curr Opin Anaesthesiol 24: 605-611.
11. Gali B, Whalen FX Jr, Gay PC, Olson EJ, Schroeder DR, et al. (2007) Management plan to reduce risks in perioperative care of patients with presumed obstructive sleep apnea syndrome. J Clin Sleep Med 3: 582-588.
12. Gupta RM, Parvizi J, Hanssen AD, Gay PC, (2001) Postoperative complications in patients with obstructive sleep apnea syndrome undergoing hip or knee replacement: a case-control study. Mayo Clin Proc 76: 897-905.
13. Blake DW, Chia PH, Donnan G, Williams DL, (2008) Preoperative assessment for obstructive sleep apnoea and the prediction of postoperative respiratory obstruction and hypoxaemia. Anaesth Intensive Care 36: 379-384.
14. Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, et al. (2008) Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep apnea in surgical patients. Anesthesiology 108: 822-830.
15. Eastwood PR, Szollosi I, Platt PR, Hillman DR, (2002) Comparison of upper airway collapse during general anaesthesia and sleep. Lancet 359: 1207-1209.
16. Ankichetty S, Wong J, Chung F, (2011) A systematic review of the effects of sedatives and anesthetics in patients with obstructive sleep apnea. J Anaesthesiol Clin Pharmacol 27: 447-458.
17. Gali B, Whalen FX, Schroeder DR, Gay PC, Plevak DJ, (2009) Identification of patients at risk for postoperative respiratory complications using a preoperative obstructive sleep apnea screening tool and postanesthesia care assessment. Anesthesiology 110: 869-877.
18. Mills PJ, Dimsdale JE, (2004) Sleep apnea: a model for studying cytokines, sleep, and sleep disruption. Brain Behav Immun 18: 298-303.
19. Smith MT, Edwards RR, McCann UD, Haythornthwaite JA, (2007) The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 30: 494-505.
20. Roehrs T, Hyde M, Blaisdell B, Greenwald M, Roth T, (2006) Sleep loss and REM sleep loss are hyperalgesic. Sleep 29: 145-151.
21. Haack M, Lee E, Cohen DA, Mullington JM, (2009) Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain. Pain 145: 136-141.
22. Smith MT, Klick B, Kozachik S, Edwards RE, Holavanahalli R, et al. (2008) Sleep onset insomnia symptoms during hospitalization for major burn injury predict chronic pain. Pain 138: 497-506.
23. Edwards RR, Almeida DM, Klick B, Haythornthwaite JA, Smith MT, (2008) Duration of sleep contributes to next-day pain report in the general population. Pain 137: 202-207.
24. Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S, (2006) Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med 166: 1756-1762.
25. Krueger JM, (2008) The role of cytokines in sleep regulation. Curr Pharm Des 14: 3408-3416.
26. Krueger JM, Clinton JM, Winters BD, Zielinski MR, Taishi P, et al. (2011) Involvement of cytokines in slow wave sleep. Prog Brain Res 193: 39-47.
27. Pollmacher T, Schuld A, Kraus T, Haack M, Hinze-Selch D, et al. (2000) Experimental immunomodulation, sleep, and sleepiness in humans. Ann N Y Acad Sci 917: 488-499.
28. Chennaoui M, Sauvet F, Drogou C, Van Beers P, Langrume C, et al. (2011) Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-alpha) levels in healthy men. Cytokine 56: 318-324.
29. Frey DJ, Fleshner M, Wright KP Jr, (2007) The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults. Brain Behav Immun 21: 1050-1057.
30. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, et al. (2004) Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89: 2119-2126.
31. Kawasaki Y, Zhang L, Cheng JK, Ji RR, (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28: 5189-5194.
32. Ren K, Dubner R, (2010) Interactions between the immune and nervous systems in pain. Nat Med 16: 1267-1276.
33. Khalid I, Roehrs TA, Hudgel DW, Roth T, (2011) Continuous positive airway pressure in severe obstructive sleep apnea reduces pain sensitivity. Sleep 34: 1687-1691.
34. Brown KA, Laferriere A, Lakheeram I, Moss IR, (2006) Recurrent hypoxemia in children is associated with increased analgesic sensitivity to opiates. Anesthesiology 105: 665-669.
35. Brown KA, Laferriere A, Moss IR, (2004) Recurrent hypoxemia in young children with obstructive sleep apnea is associated with reduced opioid requirement for analgesia. Anesthesiology 100: 806-810.
36. Olson LG, King MT, Hensley MJ, Saunders NA, (1995) A community study of snoring and sleep-disordered breathing. Health outcomes. Am J Respir Crit Care Med 152: 717-720.
37. Minto CF, Schnider TW, Egan TD, Youngs E, Lemmens HJ, et al. (1997) Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology 86: 10-23.
38. Minto CF, Schnider TW, Shafer SL, (1997) Pharmacokinetics and pharmacodynamics of remifentanil. II. Model application. Anesthesiology 86: 24-33.
39. Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, et al. (1990) Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 10: 244-251.
40. Chesson AL Jr, Berry RB, Pack A, (2003) Practice parameters for the use of portable monitoring devices in the investigation of suspected obstructive sleep apnea in adults. Sleep 26: 907-913.
41. Kushida CA, Littner MR, Morgenthaler T, Alessi CA, Bailey D, et al. (2005) Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 28: 499-521.
42. Rechtschaffen A, Kales A, editors (1968) A manual of standardized terminology, techniques and scoring system of sleep stages in human subjects. Los Angeles: Brain Information Service/Brain Research Institute, University of California.
43. American Sleep Disorders Association, (1992) EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 15: 173-184.
44. American Academy of Sleep Medicine, (1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 22: 667-689.
45. American Academy of Sleep Medicine (2005) International classification of sleep disorders: Diagnostic and coding manual. Westchester, IL: American Academy of Sleep Medicine.
46. Epstein LJ, Kristo D, Strollo PJ Jr, Friedman N, Malhotra A, et al. (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5: 263-276.
47. Meoli AL, Rosen CL, Kristo D, Kohrman M, Gooneratne N, et al. (2003) Upper airway management of the adult patient with obstructive sleep apnea in the perioperative period-avoiding complications. Sleep 26: 1060-1065.
48. Johns MW, (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14: 540-545.
49. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J, (1961) An inventory for measuring depression. Arch Gen Psychiatry 4: 561-571.
50. Bessou P, Perl ER, (1969) Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32: 1025-1043.
51. Handwerker HO, Kobal G, (1993) Psychophysiology of experimentally induced pain. Physiol Rev 73: 639-671.
52. Plaghki L, Decruynaere C, Van Dooren P, Le Bars D, (2010) The fine tuning of pain thresholds: a sophisticated double alarm system. PLoS One 5: e10269.
53. Schepers RJ, Ringkamp M, (2009) Thermoreceptors and thermosensitive afferents. Neurosci Biobehav Rev 33: 205-212.
54. Yarnitsky D, (1997) Quantitative sensory testing. Muscle Nerve 20: 198-204.
55. Wolff B (1984) Methods of testing pain mechanisms in normal man. In: Wall PD, Melzack R, editors. Textbook of Pain. Edinburgh: Churchill Livingstone. 186-194.
56. Edwards RR, Grace E, Peterson S, Klick B, Haythornthwaite JA, et al. (2009) Sleep continuity and architecture: Associations with pain-inhibitory processes in patients with temporomandibular joint disorder. Eur J Pain 13: 1043-1047.
57. Haack M, Sanchez E, Mullington JM, (2007) Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep 30: 1145-1152.
58. Smith MT, Wickwire EM, Grace EG, Edwards RR, Buenaver LF, et al. (2009) Sleep disorders and their association with laboratory pain sensitivity in temporomandibular joint disorder. Sleep 32: 779-790.
59. Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, et al. (2004) Developmental response to hypoxia. FASEB J 18: 1348-1365.
60. Kajimura S, Aida K, Duan C, (2005) Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc Natl Acad Sci U S A 102: 1240-1245.
61. Krampl E, Kametas NA, McAuliffe F, Cacho-Zegarra AM, Nicolaides KH, (2002) Maternal serum insulin-like growth factor binding protein-1 in pregnancy at high altitude. Obstet Gynecol 99: 594-598.
62. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, et al. (1998) Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci U S A 95: 10188-10193.
63. Waters KA, McBrien F, Stewart P, Hinder M, Wharton S, (2002) Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children. J Appl Physiol 92: 1987-1994.
64. Moss IR, Brown KA, Laferriere A, (2006) Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl. Anesthesiology 105: 715-718.
65. Brown KA, (2009) Intermittent hypoxia and the practice of anesthesia. Anesthesiology 110: 922-927.
66. Laferriere A, Liu JK, Moss IR, (2003) Neurokinin-1 versus mu-opioid receptor binding in rat nucleus tractus solitarius after single and recurrent intermittent hypoxia. Brain Res Bull 59: 307-313.
67. Lerman J, (2006) Unraveling the mysteries of sleep-disordered breathing in children. Anesthesiology 105: 645-647.
68. Kundermann B, Spernal J, Huber MT, Krieg JC, Lautenbacher S, (2004) Sleep deprivation affects thermal pain thresholds but not somatosensory thresholds in healthy volunteers. Psychosom Med 66: 932-937.
69. Onen SH, Alloui A, Gross A, Eschallier A, Dubray C, (2001) The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res 10: 35-42.
70. Haack M, Scott-Sutherland J, Santangelo G, Simpson NS, Sethna N, et al. (2012) Pain sensitivity and modulation in primary insomnia. Eur J Pain 16: 522-533.
71. Irwin MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, et al. (2008) Sleep loss activates cellular inflammatory signaling. Biol Psychiatry 64: 538-540.
72. Chhangani BS, Roehrs TA, Harris EJ, Hyde M, Drake C, et al. (2009) Pain sensitivity in sleepy pain-free normals. Sleep 32: 1011-1017.
73. Steinmiller CL, Roehrs TA, Harris E, Hyde M, Greenwald MK, et al. (2010) Differential effect of codeine on thermal nociceptive sensitivity in sleepy versus nonsleepy healthy subjects. Exp Clin Psychopharmacol 18: 277-283.
74. Bravo Mde L, Serpero LD, Barcelo A, Barbe F, Agusti A, et al. (2007) Inflammatory proteins in patients with obstructive sleep apnea with and without daytime sleepiness. Sleep Breath 11: 177-185.
75. Agnew HW Jr, Webb WB, Williams RL, (1966) The first night effect: an EEG study of sleep. Psychophysiology 2: 263-266.
76. Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G, et al. (2004) Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist. J Clin Endocrinol Metab 89: 4409-4413.
77. Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI, (2009) Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 32: 447-470.
78. Mohan S, Davis RL, DeSilva U, Stevens CW, (2010) Dual regulation of mu opioid receptors in SK-N-SH neuroblastoma cells by morphine and interleukin-1beta: evidence for opioid-immune crosstalk. J Neuroimmunol 227: 26-34.
79. Sachs D, Coelho FM, Costa VV, Lopes F, Pinho V, et al. (2011) Cooperative role of tumour necrosis factor-alpha, interleukin-1beta and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice. Br J Pharmacol 162: 72-83.
80. Niikura K, Narita M, Butelman ER, Kreek MJ, Suzuki T, (2010) Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission. Trends Pharmacol Sci 31: 299-305.
81. Przewlocki R, Przewlocka B, (2001) Opioids in chronic pain. Eur J Pharmacol 429: 79-91.
82. Zhang JM, An J, (2007) Cytokines, inflammation, and pain. Int Anesthesiol Clin 45: 27-37.
83. Lue FA, Bail M, Jephthah-Ochola J, Carayanniotis K, Gorczynski R, et al. (1988) Sleep and cerebrospinal fluid interleukin-1-like activity in the cat. Int J Neurosci 42: 179-183.
84. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, et al. (1999) Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 84: 2603-2607.
85. Ryan S, Taylor CT, McNicholas WT, (2005) Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112: 2660-2667.
86. Schafers M, Sorkin L, (2008) Effect of cytokines on neuronal excitability. Neurosci Lett 437: 188-193.
87. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, et al. (2008) Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med 14: 331-336.
88. Sorkin LS, Xiao WH, Wagner R, Myers RR, (1997) Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience 81: 255-262.
89. Hua S, Cabot PJ, (2010) Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications. Trends Pharmacol Sci 31: 427-433.