Association between Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism and Sepsis: A Meta-Analysis

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Li, Li ^a   Nie, Wei ^b   Zhou, Hongfeng ^c   Yuan, Weifeng ^a   Li, Weifeng ^a   Huang, Wenjie ^a  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; ETHNICITY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MORTALITY; PLASMINOGEN ACTIVATOR INHIBITOR 1 GENE; RISK ASSESSMENT; SEPSIS;

GENETIC ASSOCIATION STUDIES; HUMANS; ODDS RATIO; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBLICATION BIAS; RISK; SEPSIS;

EID: 84873851230     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054883     Document Type: Article

References (39)

1. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL, (2007) Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Crit Care Med 35: 1244-1250.
2. Hermans P, Hazelzet JA, (2005) Plasminogen activator inhibitor type 1 gene polymorphism and sepsis. Clin Infect Dis 41: S453-S458.
3. Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA, (2006) TAFI and PAI-1 levels in human sepsis. Thromb Res 118: 205-212.
4. Madoiwa S, Nunomiya S, Ono T, Shintani Y, Ohmori T, et al. (2006) Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation. Int J Hematol 84: 398-405.
5. Kornelisse RF, Hazelzet JA, Savelkoul HFJ, Hop WCJ, Suur MH, et al. (1996) The relationship between plasminogen activator inhibitor-1 and proinflammatory and counterinflammatory mediators in children with meningococcal septic shock. J Infect Dis 173: 1148-1156.
6. Hermans PWM, Hibberd ML, Booy R, Daramola O, Hazelzet JA, et al. (1999) 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Lancet 354: 556-560.
7. Eriksson P, Kallin B, Van't Hooft FM, Båvenholm P, Hamsten A, (1995) Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. P Natl Acad Sci USA 92: 1851-1855.
8. Westendorp RG, Hottenga JJ, Slagboom PE, (1999) Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock. Lancet 354: 561-563.
9. Menges T, Hermans PWM, Little SG, Langefeld T, Böning O, et al. (2001) Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients. Lancet 357: 1096-1097.
10. Haralambous E, Hibberd ML, Hermans PWM, Ninis N, Nadel S, et al. (2003) Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit Care Med 31: 2788-2793.
11. Geishofer G, Binder A, Müller M, Zöhrer B, Resch B, et al. (2005) 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene in children with systemic meningococcaemia. Eur J Pediatr 164: 486-490.
12. Zhan Z, Wang H, Chen D, Cheng B, Wang H, et al. (2005) Relationship between sepsis and 4G/5G polymorphism within the promoter region of plasminogen activator inhibitor-1 gene. Zhonghua Yi Xue Za Zhi 85: 2404-2407.
13. Sipahi T, Pocan H, Akar N, (2006) Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. Clin Appl Thromb Hemost 12: 47-54.
14. García-Segarra G, Espinosa G, Tassies D, Oriola J, Aibar J, et al. (2007) Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent. Intensive Care Med 33: 1354-1362.
15. Jessen K, Lindboe S, Petersen A, Eugen-Olsen J, Benfield T, (2007) Common TNF-α, IL-1β, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis 7: 108-115.
16. Wei Y, Zeng Q, Zeng H, (2008) 4G/5G promoter polymorphism in the plasminogen activator inhibitor 1 gene in children with sepsis. Chin J Evid Based Pediatr 3: 280-285.
17. Henckaerts L, Nielsen KR, Steffensen R, Van Steen K, Mathieu C, et al. (2009) Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 37: 192-201.
18. Peres Wingeyer S, de Larranaga G, Cunto E, Fontana L, Nogueras C, et al. (2010) Role of 4G/5G promoter polymorphism of Plasminogen Activator Inhibitor-1 (PAI-1) gene in outcome of sepsis. Thromb Res 125: 367-369.
19. Lorente L, Martin M, Labarta L, Diaz C, Sole-Violan J, et al. (2009) Role of 4G/5G plasminogen activator inhibitor-1 (PAI-1) gene polymorphism and the PAI-1 plasma levels in the outcome of patients with severe sepsis. Crit Care 13: S143-S144.
20. Madach K, Aladzsity I, Szilagyi A, Fust G, Gal J, et al. (2010) 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. Crit Care 14: R79-88.
21. Wingeyer SP, Cunto E, Nogueras C, Juan JS, Norberto G, et al. (2012) Biomarkers in sepsis at time zero: Intensive care unit scores, plasma measurements and polymorphisms in Argentina. J Infect Dev Ctries 6: 555-562.
22. Clark MF, Baudouin SV, (2006) A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med 32: 1706-1712.
23. Thakkinstian A, McElduff P, D'Este C, Duffy D, Attia J, (2005) A method for meta-analysis of molecular association studies. Stat Med 24: 1291-1306.
24. Nie W, Fang Z, Li B, Xiu Q, (2012) Interleukin-10 promoter polymorphisms and asthma risk: A meta-analysis. Cytokine 60: 849-855.
25. Nie W, Chen J, Xiu Q, (2012) Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis. PLoS ONE 7: e42062.
26. Egger M, Smith GD, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
27. Esmon CT, (2004) Crosstalk between inflammation and thrombosis. Maturitas 47: 305-314.
28. Semeraro N, Ammollo CT, Semeraro F, Colucci M, (2011) Sepsis, thrombosis and organ dysfunction. Thromb Res 129: 290-295.
29. Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, et al. (1992) Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 101: 816-823.
30. Mann KG, (1999) Biochemistry and physiology of blood coagulation. Thromb Haemost 82: 165-174.
31. Horrevoets AJG, (2004) Plasminogen activator inhibitor 1 (PAI-1): in vitro activities and clinical relevance. Br J Haematol 125: 12-23.
32. Semeraro N, Ammollo CT, Semeraro F, Colucci M, (2010) Sepsis-associated disseminated intravascular coagulation and thromboembolic disease. Mediterr J Hematol Infect Dis 2: e2010024.
33. Mesters R, Flörke N, Ostermann H, Kienast J, (1996) Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis. Thromb Haemost 75: 902-907.
34. Biemond B, Levi M, Ten Cate H, Van der Poll T, Büller H, et al. (1995) Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades. Clin Sci 88: 587-594.
35. Dawson S, Wiman B, Hamsten A, Green F, Humphries S, et al. (1993) The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 268: 10739-10745.
36. Festa A, D'Agostino R, Rich SS, Jenny NS, Tracy RP, et al. (2003) Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites. Circulation 107: 2422-2427.
37. Salanti G, Sanderson S, Higgins JPT, (2005) Obstacles and opportunities in meta-analysis of genetic association studies. Genet Med 7: 13-20.
38. Sutherland AM, Walley KR, (2009) Bench-to-bedside review: Association of genetic variation with sepsis. Crit Care 13: 210-220.
39. Wong HR, (2012) Genetics and genomics in pediatric septic shock. Crit Care Med 40: 1618-1626.