Predicting treatment response in major depressive disorder: the impact of early symptomatic improvement

Canadian Journal of Psychiatry

Volumn 57, Issue 12, 2012, Pages 782-788

  Kudlow, Paul A ^a,b   Cha, Danielle S ^a,c   McIntyre, Roger S ^d,e  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b WESTERN UNIVERSITY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Antidepressants; Early improvement; Major depressive disorder; Onset of antidepressant effects; Time factors; Treatment response

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; DESIPRAMINE; DULOXETINE; ESCITALOPRAM; FLUOXETINE; IMIPRAMINE; MIANSERIN; MIRTAZAPINE; MOCLOBEMIDE; OXAPROTILINE; PAROXETINE; PHENELZINE; PLACEBO; REBOXETINE; SELEGILINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TRANYLCYPROMINE;

ANXIETY; CLINICAL GLOBAL IMPRESSION SCALE; COGNITION; COGNITIVE THERAPY; DRUG EFFICACY; DRUG MONITORING; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EMOTION; HAMILTON SCALE; HUMAN; HYPOTHESIS; MAJOR DEPRESSION; METHODOLOGY; MOOD; OPTIMAL DRUG DOSE; OUTCOME ASSESSMENT; PATIENT HEALTH QUESTIONNAIRE 9; PREDICTION; PREDICTIVE VALUE; PSYCHOTHERAPY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; REVIEW; SINGLE DRUG DOSE; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT RESPONSE;

EID: 84873846205     PISSN: 07067437     EISSN: 14970015     Source Type: Journal    
DOI: 10.1177/070674371205701211     Document Type: Review

References (34)

1. Szegedi A, Janse WT, van Willigenburg AP, et al. Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: A meta-analysis including 6562 patients. J Clin Psychiatry. 2009;70(3):344-353.
2. Nierenberg AA, McLean NE, Alpert JE, et al. Early nonresponse to fluoxetine as a predictor of poor 8-week outcome. Am J Psychiatry. 1995;152(10):1500-1503.
3. Parker G, Roy K, Menkes DB, et al. How long does it take for antidepressant therapies to act? Aust N Z J Psychiatry. 2000;34(1):65-70.
4. Quitkin FM, Rabkin JG, Ross D, et al. Identification of true drug response to antidepressants. Use of pattern analysis. Arch Gen Psychiatry. 1984;41(8):782-786.
5. Quitkin FM, Rabkin JG, Ross D, et al. Duration of antidepressant drug treatment. What is an adequate trial? Arch Gen Psychiatry. 1984;41(3):238-245.
6. Posternak MA, Baer L, Nierenberg A, et al. Response rates to fluoxetine in subjects who initially show no improvement. J Clin Psychiatry. 2011;72(7):949-954.
7. Papakostas GI, Crawford CM, Scalia MJ, et al. Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericum perforatum versus fluoxetine. Neuropsychobiology. 2007;56(2-3):132-137.
8. Papakostas GI, Petersen TJ, Iosifescu DV, et al. Somatic symptoms as predictors of time to onset of response to fluoxetine in major depressive disorder. J Clin Psychiatry. 2004;65(4):543-546.
9. Kirsch I, Deacon BJ, Huedo-Medina TB, et al. Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Med. 2008;5(2):e45.
10. Fournier JC, DeRubeis RJ, Hollon SD, et al. Antidepressant drug effects and depression severity: A patient-level meta-analysis. JAMA. 2010;303(1):47-53.
11. Posternak MA, Baer L, Nierenberg A, et al. Response rates to fluoxetine in subjects who initially show no improvement. J Clin Psychiatry. 2011;72(7):949-954.
12. Katz MM, Tekell JL, Bowden CL, et al. Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression. Neuropsychopharmacology. 2004;29(3):566-579.
13. Stassen HH, Angst J, Hell D, et al. Is there a common resilience mechanism underlying antidepressant drug response? Evidence from 2848 patients. J Clin Psychiatry. 2007;68(8):1195-1205.
14. Farabaugh A, Sonawalla S, Johnson DP, et al. Early improvements in anxiety, depression, and anger/hostility symptoms and response to antidepressant treatment. Ann Clin Psychiatry. 2010;22(3):166-171.
15. Harmer CJ, O'Sullivan U, Favaron E, et al. Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry. 2009;166(10):1128-1184.
16. Tranter R, Bell D, Gutting P, et al. The effect of serotonergic and noradrenergic antidepressants on face emotion processing in depressed patients. J Affect Disord. 2009;118(1-3):87-93.
17. Taylor MJ, Freemantle N, Geddes JR, et al. Early onset of selective serotonin reuptake inhibitor antidepressant action: Systematic review and meta-analysis. Arch Gen Psychiatry. 2006;63(11):1217-1223.
18. Uher R, Muthén B, Souery D, et al. Trajectories of change in depression severity during treatment with antidepressants. Psychol Med. 2010;40(8):1367-1377.
19. Uher R, Mors O, Rietschel M, et al. Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression: A secondary analysis of data from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. J Clin Psychiatry. 2011;72(11):1478-1484.
20. Gueorguieva R, Mallinckrodt C, Krystal JH. Trajectories of depression severity in clinical trials of duloxetine: Insights into antidepressant and placebo responses. Arch Gen Psychiatry. 2011;68(12):1227-1237.
21. Kim JM, Kim SY, Stewart R, et al. Improvement within 2 weeks and later treatment outcomes in patients with depressive disorders: The CRESCEND study. J Affect Disord. 2011;129(1-3):183-190.
22. Tadić A, Helmreich I, Mergl R, et al. Early improvement is a predictor of treatment outcome in patients with mild major, minor or subsyndromal depression. J Affect Disord. 2010;120(1-3):86-93.
23. Tadić A, Wagner S, Gorbulev S, et al. Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with major depressive disorder. BMC Psychiatry. 2011;11(16):1-10.
24. Mulsant BH, Houck PR, Gildengers AG, et al. What is the optimal duration of a short-term antidepressant trial when treating geriatric depression? J Clin Psychopharmacol. 2006;26(2):113-120.
25. Henkel V, Seemüller F, Obermeier M, et al. Does early improvement triggered by antidepressants predict response/remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression. J Affect Disord. 2009;115(3):439-449.
26. Parker G, Roy K, Menkes DB, et al. How long does it take for antidepressant therapies to act? Aust N Z J Psychiatry. 2000;34(1):65-70.
27. Quitkin FM, McGrath PJ, Stewart JW, et al. Chronological milestones to guide drug change. When should clinicians switch antidepressants? Arch Gen Psychiatry. 1996;53(9):785-792.
28. Quitkin FM, Petkova E, McGrath PJ, et al. When should a trial of fluoxetine for major depression be declared failed? J Clin Psychiatry. 2003;160(4):734-740.
29. van Calker D, Zobel I, Dykierek P, et al. Time course of response to antidepressants: Predictive value of early improvement and effect of additional psychotherapy. J Affect Disord. 2009;114(1-3):243-253.
30. Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice. Am J Psychiatry. 2006;163(1):28-40.
31. Romera I, Perez V, Menchon JM, et al. Early vs delayed switch to duloxetine in patients with major depressive disorder not exhibiting early improvement with escitalopram: A double-blind randomized study. Paper presented at the meeting of the International Forum on Mood and Anxiety Disorders (IFMAD); 2010 Nov 17-19; Vienna, Austria.
32. Sagman D, McIntosh D, Lee MS, et al. Attributes of response in depressed patients switched to treatment with duloxetine. Int J Clin Pract. 2011;65(1):73-81.
33. Sheehan DV, Chokka PR, Granger RE, et al. Clinical and functional outcomes in patients with major depressive disorder and painful physical symptoms switched to treatment with duloxetine. Hum Psychopharmacol. 2011;26(3):242-251.
34. McIntyre RS, Konarski JZ, Mancini DA, et al. Measuring the severity of depression and remission in primary care: Validation of the HAMD-7 scale. CMAJ. 2005;173(11):1327-1334.