Interleukin-10 gene modification attenuates hepatocyte activation of rat hepatic stellate cells in vitro

Molecular Medicine Reports

Volumn 7, Issue 2, 2013, Pages 371-378

  Chen, Yun Xin ^a   Huang, Yue Hong ^a   Zheng, Wei Da ^a   Chen, Zhi Xin ^a   Zhang, Li Juan ^a   Wang, Xiao Zhong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cytokine; Gene therapy; Hepatic stellate cell; Hepatocyte; Interleukin 10; Liver fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ASIALOGLYCOPROTEIN RECEPTOR; COLLAGEN TYPE 1; INTERLEUKIN 10; LIPOSOME; TRANSFAST; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL STIMULATION; COCULTURE; DNA MODIFICATION; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; LIPOSOMAL DELIVERY; LIVER CELL CULTURE; MALE; NONHUMAN; RAT; STELLATE CELL;

ACTINS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; COLLAGEN TYPE I; HEPATIC STELLATE CELLS; HEPATOCYTES; INTERLEUKIN-10; LIPOSOMES; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION;

EID: 84873812702     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1228     Document Type: Article

References (26)

1. Friedman SL: Cytokines and fibrogenesis. Semin Liver Dis 19: 129-140, 1999
2. Rockey DC: Current and future anti-fibrotic therapies for chronic liver disease. Clin Liver Dis 12: 939-962, 2008.
3. Thompson K, Maltby J, Fallowfield J, McAulay M, Millward-Sadler H and Sheron N: Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis. Hepatology28: 1597-1606, 1998
4. Louis H, Van Laethem JL, Wu W, et al: Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 28: 1607-1615, 1998.
5. Nelson DR, Lauwers GY, Lau JY and Davis GL: Interleukin-10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trail of interferon nonresponders. Gastroenterology 118: 655-660, 2000.
6. Wang XZ, Zhang LJ, Li D, Huang YH, Chen ZX and Li B: Effects of transmitters and interleukin-10 on rat hepatic fibrosis induced by CCl4. World J Gastroenterol 9: 539-543, 2003.
7. Rachmawati H, Reker-Smit C, Lub-de Hooge MN, vanLoenen-Weemaes A, Poelstra K and Beljaars L: Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine. Drug Metab Dispos 35: 814-821, 2007.
8. Hung KS, Lee TH, Chou WY, et al: Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice. Biochem Biophys Res Commun 336: 324-331, 2005.
9. Chen YX, Huang YH, Chen ZX, Zheng WD and Wang XZ: Construction of eukaryotic expression plasmid containing rat interleukin-10 gene and its expression in BRL cells invitro. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 332-334, 2008 (In Chinese).
10. Ramm GA: Isolation and culture of rat hepatic stellate cells. J Gastroenterol Hepatol 13: 846-851, 1998.
11. Huhn RD, Radwanski E, O'Connell SM, et al: Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers. Blood 87: 699-705, 1996.
12. Rachmawati H, Beljaars L, Reker-Smit C, et al: Pharmacokinetic and biodistribution profile of recombinant human interleukin-10 following intravenous administration in rats with extensive liver fibrosis. Pharm Res 21: 2072-2078, 2004.
13. Mathurin P, Xiong S, Kharbanda KK, et al: IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 282: G981-G990, 2002.
14. Safadi R, Ohta M, Alvarez CE, et al: Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 127: 997-1000, 2004.
15. Louis H, Le Moine O, Peny MO, et al: Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice. Hepatology 25: 1382-1389, 1997.
16. Di Stefano G, Derenzini M, Kratz F, Lanza M and Fiume L: Liver-targeted doxorubicin: effects on rat regenerating hepatocytes. Liver Int 24: 246-252, 2004.
17. Wang S, Cheng L, Yu F, Pan W and Zhang J: Delivery of different length poly(L-lysine)-conjugated ODN to Hep G2 cells using N-stearyl lactobionamide-modified liposomes and their enhanced cellular biological effects. Int J Pharm 311: 82-88, 2006.
18. Lan L, Chen Y, Sun C, Sun Q, Hu J and Li D: Transplantation of bone marrow-derived hepatocyte stem cells transduced with adenovirus-mediated IL-10 gene reverses liver fibrosis in rats. Transpl Int 21: 581-592, 2008.
19. Tashiro H, Shinozaki K, Yahata H, et al: Prolongation of liver allograft survival after interleukin-10 gene transduction 24-48 hours before donation. Transplantation 70: 336-339, 2000.
20. Gressner AM, Lotfi S, Gressner G and Lahme B: Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat-storing cells (parasinusoidal lipocytes). Hepatology 16: 1250-1266, 1992.
21. Faouzi S, Lepreux S, Bedin C, et al: Activation of cultured rat hepatic stellate cells by tumoral hepatocytes. Lab Invest 79: 485-493, 1999.
22. Gressner AM, Lotfi S, Gressner G, Haltner E and Kropf J: Synergism between hepatocytes and Kupffer cells in the activation of fat storing cells (perisinusoidal lipocytes). J Hepatol 19: 117-132, 1993.
23. Saile B, Knittel T, Matthes N, Schott P and Ramadori G: CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol 151: 1265-1272, 1997.
24. Issa R, Williams E, Trim N, et al: Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 48: 548-557, 2001.
25. Zhang LJ, Zheng WD, Shi MN and Wang XZ: Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver. World J Gastroenterol 12: 1918-1923, 2006.
26. Chen YX, Wang XZ, Weng SG, Chen ZX, Huang YH and Zhang LJ: Effects of interleukin-10 on the proliferation and Fas/Fas ligand expression of hepatic stellate cells. Zhonghua Gan Zang Bing Za Zhi 11: 637-640, 2003 (In Chinese).