Disruption of ionic interactions between the nucleotide binding domain 1 (NBD1) and middle (M) domain in Hsp100 disaggregase unleashes toxic hyperactivity and partial independence from Hsp70

Journal of Biological Chemistry

Volumn 288, Issue 4, 2013, Pages 2857-2869

  Lipińska, Natalia ^a   Zietkiewicz, Szymon ^a   Sobczak, Alicja ^a   Jurczyk, Agnieszka ^a   Potocki, Wojciech ^a   Morawiec, Ewa ^a   Wawrzycka, Aleksandra ^a   Gumowski, Krzysztof ^a   Ślusarz, Magdalena ^a   Rodziewicz Motowidło, Sylwia ^a   Chruściel, Elzbieta ^a   Liberek, Krzysztof ^a  

^a UNIVERSITY OF GDA SK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDES; YEAST;

AGGREGATED PROTEIN; ATP-ASE ACTIVITY; BIOCHEMICAL PROPERTIES; DISAGGREGATION REACTION; HSP70 CHAPERONES; IONIC INTERACTION; NUCLEOTIDE-BINDING DOMAIN; STRUCTURAL ASPECTS;

PROTEINS;

CHAPERONE; HEAT SHOCK PROTEIN 100; HEAT SHOCK PROTEIN 70; NUCLEOTIDE BINDING DOMAIN 1; NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN UNFOLDING; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 84873802635     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.387589     Document Type: Article

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